- Thienopyridines, but Not Elinogrel, Result in Off-Target Effects at the Vessel Wall That Contribute to Bleeding
[作者:Andre, P; DeGuzman, F; Haberstock-Debic, H; Mills, S; Pak, Y; Inagaki, M; Pandey, A; Hollenbach, S; Phillips, DR; Conley, PB,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:22-30 , 文章类型: Article,,卷期:2011年338-1]
- Clinical studies with clopidogrel or prasugrel show that although increased inhibition of P2Y(12) and platelet function improves efficacy, bleeding is also increased. Other preclinical and clinical studies have suggested...
- The Efficacy of Sodium Channel Blockers to Prevent Phencyclidine-Induced Cognitive Dysfunction in the Rat: Potential for Novel Treatments for Schizophrenia
[作者:Large, CH; Bison, S; Sartori, I; Read, KD; Gozzi, A; Quarta, D; Antolini, M; Hollands, E; Gill, CH; Gunthorpe, MJ; Idris, N; Neill, JC; Alvaro, GS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:100-113 , 文章类型: Article,,卷期:2011年338-1]
- Sodium channel inhibition is a well precedented mechanism used to treat epilepsy and other hyperexcitability disorders. The established sodium channel blocker and broad-spectrum anticonvulsant lamotrigine is also effecti...
- Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain
[作者:Ahn, K; Smith, SE; Liimatta, MB; Beidler, D; Sadagopan, N; Dudley, DT; Young, T; Wren, P; Zhang, YH; Swaney, S; Van Becelaere, K; Blankman, JL; Nomura, DK; Bhattachar, SN; Stiff, C; Nomanbhoy, TK; Weerapana, E; Johnson, DS; Cravatt, BF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:114-124 , 文章类型: Article,,卷期:2011年338-1]
- The endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the integral membrane enzyme fatty acid amide hydrolase (FAAH). Pharmacological blockade of FAAH has emerged as a potentially attractive ...
- Increased Activation of the Wnt/beta-Catenin Pathway in Spontaneous Hepatocellular Carcinoma Observed in Farnesoid X Receptor Knockout Mice
[作者:Wolfe, A; Thomas, A; Edwards, G; Jaseja, R; Guo, GL; Apte, U,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:12-21 , 文章类型: Article,,卷期:2011年338-1]
- Farnesoid X receptor (FXR), the primary bile acid-sensing nuclear receptor, also is known for its anticancer properties. It is known that FXR deficiency in mice results in spontaneous hepatocellular carcinoma (HCC), but ...
- Naturally Occurring Variations in the Human Cholinesterase Genes: Heritability and Association with Cardiovascular and Metabolic Traits
[作者:Valle, AM; Radic, Z; Rana, BK; Mahboubi, V; Wessel, J; Shih, PAB; Rao, FW; O'Connor, DT; Taylor, P,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:125-133 , 文章类型: Article,,卷期:2011年338-1]
- Cholinergic neurotransmission in the central and autonomic nervous systems regulates immediate variations in and longer-term maintenance of cardiovascular function with acetylcholinesterase (AChE) activity that is critic...
- Pharmacological Targeting of Glucagon and Glucagon-Like Peptide 1 Receptors Has Different Effects on Energy State and Glucose Homeostasis in Diet-Induced Obese Mice
[作者:Gu, W; Lloyd, DJ; Chinookswong, N; Komorowski, R; Sivits, G; Graham, M; Winters, KA; Yan, H; Boros, LG; Lindberg, RA; Veniant, MM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:70-81 , 文章类型: Article,,卷期:2011年338-1]
- Pharmacologic contributions of directly agonizing glucagon-like peptide 1 (GLP-1) receptor or antagonizing glucagon receptor (GCGR) on energy state and glucose homeostasis were assessed in diet-induced obese (DIO) mice. ...
- Regulation of kappa-Opioid Receptor Signaling in Peripheral Sensory Neurons In Vitro and In Vivo
[作者:Berg, KA; Rowan, MP; Sanchez, TA; Silva, M; Patwardhan, AM; Milam, SB; Hargreaves, KM; Clarke, WP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:92-99 , 文章类型: Article,,卷期:2011年338-1]
- There is considerable interest in understanding the regulation of peripheral opioid receptors to avoid central nervous system side effects associated with systemically administered opioid analgesics. Here, we investigate...
- Rho Kinase Inhibition by Fasudil Attenuates Cyclosporine-Induced Kidney Injury
[作者:Park, JW; Park, CH; Kim, IJ; Bae, EH; Ma, SK; Lee, JU; Kim, SW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:271-279 , 文章类型: Article,,卷期:2011年338-1]
- It has been shown that the inhibition of the Rho/Rho kinase (ROCK) pathway prevents tubulointerstitial fibrosis and ameliorates renal function in various progressive renal disorders. The present study was to determine wh...
- Abuse Liability Profile of Three Substituted Tryptamines
[作者:Gatch, MB; Forster, MJ; Janowsky, A; Eshleman, AJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:280-289 , 文章类型: Article,,卷期:2011年338-1]
- The abuse liability profile of three synthetic hallucinogens, N,N-diisopropyltryptamine (DIPT), 5-N,N-diethyl-5-methoxytryptamine (5-MeO-DET), and 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), was tested in rats trained ...
- Pharmacology of AM211, a Potent and Selective Prostaglandin D(2) Receptor Type 2 Antagonist That Is Active in Animal Models of Allergic Inflammation
[作者:Bain, G; Lorrain, DS; Stebbins, KJ; Broadhead, AR; Santini, AM; Prodanovich, P; Darlington, J; King, CD; Lee, C; Baccei, C; Stearns, B; Troung, Y; Hutchinson, JH; Prasit, P; Evans, JF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:290-301 , 文章类型: Article,,卷期:2011年338-1]
- The prostaglandin D(2) (PGD(2)) receptor type 2 (DP2) is a G protein-coupled receptor that has been shown to be involved in a variety of allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis. In t...
- A Method to Quantify Illicit Intake of Drugs from Urine: Methamphetamine
[作者:Li, LH; Galloway, GP; Verotta, D; Everhart, ET; Baggott, MJ; Coyle, JR; Lopez, JC; Mendelson, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:31-36 , 文章类型: Article,,卷期:2011年338-1]
- Qualitative urinalysis can verify abstinence of drug misuse but cannot detect changes in drug intake. For drugs with slow elimination, such as methamphetamine (MA), a single episode of abuse can result in up to 5 days of...
- Metabolism and Disposition of 3,4-Methylenedioxymethamphetamine ("Ecstasy") in Baboons after Oral Administration: Comparison with Humans Reveals Marked Differences
[作者:Mueller, M; Goodwin, AK; Ator, NA; McCann, UD; Ricaurte, GA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:310-317 , 文章类型: Article,,卷期:2011年338-1]
- The baboon is potentially an attractive animal for modeling 3,4-methylenedioxymethamphetamine (MDMA) effects in humans. Baboons self-administer MDMA, are susceptible to MDMA neurotoxicity, and are suitable for positron e...
- Identification of a High-Affinity Ligand That Exhibits Complete Aryl Hydrocarbon Receptor Antagonism
[作者:Smith, KJ; Murray, IA; Tanos, R; Tellew, J; Boitano, AE; Bisson, WH; Kolluri, SK; Cooke, MP; Perdew, GH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:318-327 , 文章类型: Article,,卷期:2011年338-1]
- The biological functions of the aryl hydrocarbon receptor (AHR) can be delineated into dioxin response element (DRE)-dependent or -independent activities. Ligands exhibiting either full or partial agonist activity, e.g.,...
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