- Paw Inflammation Model in Dogs for Preclinical Pharmacokinetic/Pharmacodynamic Investigations of Nonsteroidal Anti-Inflammatory Drugs
[作者:Jeunesse, EC; Bargues, IA; Toutain, CE; Lacroix, MZ; Letellier, IM; Giraudel, JM; Toutain, PL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:548-558 , 文章类型: Article,,卷期:2011年338-2]
- The goal of the present study was to develop and validate a new canine model of inflammation. The motivation was to make available a scientifically appropriate and ethically acceptable model to conduct pharmacokinetic/ph...
- Agonist-Induced Desensitization/Resensitization of Human G Protein-Coupled Receptor 17: A Functional Cross-Talk between Purinergic and Cysteinyl-Leukotriene Ligands
[作者:Daniele, S; Trincavelli, ML; Gabelloni, P; Lecca, D; Rosa, P; Abbracchio, MP; Martini, C,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:559-567 , 文章类型: Article,,卷期:2011年338-2]
- G protein-coupled receptor (GPR) 17 is a P2Y-like receptor that responds to both uracil nucleotides (as UDP-glucose) and cysteinyl- leukotrienes (cysLTs, as LTD(4)). By bioinformatic analysis, two distinct binding sites ...
- A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody
[作者:Glantschnig, H; Scott, K; Hampton, R; Wei, N; McCracken, P; Nantermet, P; Zhao, JZ; Vitelli, S; Huang, LY; Haytko, P; Lu, P; Fisher, JE; Sandhu, P; Cook, J; Williams, D; Strohl, W; Flores, O; Kimmel, D; Wang, FB; An, ZQ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:568-578 , 文章类型: Article,,卷期:2011年338-2]
- Genetic studies have linked both osteoporotic and high bone mass phenotypes to low-density lipoprotein receptor-related proteins (LRP4, LRP5, and LRP6). LRPs are receptors for inhibitory Dickkopf-1 (DKK1) protein, and tr...
- Pentazocine-Induced Antinociception Is Mediated Mainly by mu-Opioid Receptors and Compromised by kappa-Opioid Receptors in Mice
[作者:Shu, HH; Hayashida, M; Arita, H; Huang, WQ; Zhang, H; An, K; Wu, GY; Hanaoka, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:579-587 , 文章类型: Article,,卷期:2011年338-2]
- Pentazocine is a widely used mixed agonist-antagonist opioid. Previous animal studies have demonstrated that pentazocine-induced antinociception displayed a ceiling effect characterized by biphasic dose response with a i...
- Decreased Cytochrome c Oxidase IV Expression Reduces Steroidogenesis
[作者:Pawlak, KJ; Prasad, M; McKenzie, KA; Wiebe, JP; Gairola, CG; Whittal, RM; Bose, HS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:598-604 , 文章类型: Article,,卷期:2011年338-2]
- Steroidogenic acute regulatory protein facilitates the translocation of cholesterol to the inner mitochondrial membrane, thereby initiating steroidogenesis. At the inner mitochondrial membrane, cytochrome P450 side-chain...
- The Role of 5-Hydroxytryptamine 7 Receptors in the Phencyclidine-Induced Novel Object Recognition Deficit in Rats
[作者:Horiguchi, M; Huang, M; Meltzer, HY,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:605-614 , 文章类型: Article,,卷期:2011年338-2]
- The role of 5-hydroxytryptamine (serotonin) (5-HT)(7) receptor antagonism in the actions of atypical antipsychotic drugs (APDs), e. g., amisulpride, clozapine, and lurasidone, if any, is uncertain. We examined the abilit...
- Anxiolytic-Like Activity of Pregabalin in the Vogel Conflict Test in alpha(2)delta-1 (R217A) and alpha(2)delta-2 (R279A) Mouse Mutants
[作者:Lotarski, SM; Donevan, S; El-Kattan, A; Osgood, S; Poe, J; Taylor, CP; Offord, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:615-621 , 文章类型: Article,,卷期:2011年338-2]
- The alpha(2)delta auxiliary subunits (alpha(2)delta-1 and alpha(2)delta-2) of voltage-sensitive calcium channels are thought to be the site of action of pregabalin (Lyrica), a drug that has been shown to be anxiolytic in...
- Pharmacological Characterization of LY593093, an M1 Muscarinic Acetylcholine Receptor-Selective Partial Orthosteric Agonist
[作者:Watt, ML; Schober, DA; Hitchcock, S; Liu, B; Chesterfield, AK; McKinzie, D; Felder, CC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:622-632 , 文章类型: Article,,卷期:2011年338-2]
- Alzheimer's disease and schizophrenia are characterized by expression of psychotic, affective, and cognitive symptoms. Currently, there is a lack of adequate treatment for the cognitive symptoms associated with these dis...
- A Novel Knock-In Mouse Reveals Mechanistically Distinct Forms of Morphine Tolerance
[作者:Enquist, J; Kim, JA; Bartlett, S; Ferwerda, M; Whistler, JL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:633-640 , 文章类型: Article,,卷期:2011年338-2]
- The role of mu-opioid receptor (MOR) down-regulation in opioid tolerance remains controversial. In this study, we used a novel knock-in mouse to examine how changing the extent of MOR down-regulation alters the developme...
- Effects of Repeated Treatment with Phosphodiesterase-4 Inhibitors on cAMP Signaling, Hippocampal Cell Proliferation, and Behavior in the Forced-Swim Test
[作者:Xiao, L; O'Callaghan, JP; O'Donnell, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:641-647 , 文章类型: Article,,卷期:2011年338-2]
- The effects of repeated treatment with the phosphodiesterase-4 (PDE4) inhibitors rolipram, piclamilast, and 4-(2-(3-(cyclopentyloxy)- 4-methoxyphenyl)-2-phenylethyl) pyridine (CDP840), which differ in their interactions ...
- The Affinity of D(2)-Like Dopamine Receptor Antagonists Determines the Time to Maximal Effect on Cocaine Self-Administration
[作者:Norman, AB; Tabet, MR; Norman, MK; Fey, BK; Tsibulsky, VL; Millard, RW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:724-728 , 文章类型: Article,,卷期:2011年338-2]
- Differences in the time to maximal effect (T(max)) of a series of dopamine receptor antagonists on the self-administration of cocaine are not consistent with their lipophilicity (octanol-water partition coefficients at p...
- The Microtubule- Targeting Agents, PBOX-6 [Pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[ 2,1-d] (1,5)-benzoxazepine] and Paclitaxel, Induce Nucleocytoplasmic Redistribution of the Peptidyl-Prolyl Isomerases, Cyclophilin A and Pin1, in Malignant Hematopoietic Cells (vol 329, pg 38, 2009)
[作者:Bane, FT; Bannon, JH; Pennington, SR; Campiani, G; Williams, DC; Zisterer, DM; Mc Gee, MM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:729-729 , 文章类型: Correction,,卷期:2011年338-2]
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- alpha(1)-Adrenergic Receptors Positively Regulate Toll-Like Receptor Cytokine Production from Human Monocytes and Macrophages
[作者:Grisanti, LA; Woster, AP; Dahlman, J; Sauter, ER; Combs, CK; Porter, JE,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:648-657 , 文章类型: Article,,卷期:2011年338-2]
- Catecholamines released from the sympathetic nervous system in response to stress or injury affect expression of inflammatory cytokines generated by immune cells. alpha(1)-Adrenergic receptors (ARs) are expressed on inna...
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