- Inhibition of Smooth Muscle Myosin as a Novel Therapeutic Target for Hypertension
[作者:Zhao, X; Ho, D; Abarzua, P; Dhar, SK; Wang, X; Jia, ZH; Pannirselvam, M; Morgans, DJ; Malik, FI; Vatner, SF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:307-312 , 文章类型: Article,,卷期:2011年339-1]
- We examined a novel therapeutic approach for hypertension, a small-molecule direct inhibitor of smooth muscle myosin, CK-2018448 (CK-448), which is an N,N'-alkylurea (U. S. Patent Publication 2009-0275537 A1) in consciou...
- Novel Peptide Antagonists of Adrenomedullin and Calcitonin Gene-Related Peptide Receptors: Identification, Pharmacological Characterization, and Interactions with Position 74 in Receptor Activity-Modifying Protein 1/3 (vol 331, pg 513, 2009)
[作者:Robinson, SD; Aitken, JF; Bailey, RJ; Poyner, DR; Hay, DL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:321-321 , 文章类型: Correction,,卷期:2011年339-1]
-
- Omeprazole Attenuates Hyperoxic Lung Injury in Mice via Aryl Hydrocarbon Receptor Activation and Is Associated with Increased Expression of Cytochrome P4501A Enzymes
[作者:Shivanna, B; Jiang, WW; Wang, LH; Couroucli, XI; Moorthy, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:106-114 , 文章类型: Article,,卷期:2011年339-1]
- Hyperoxia contributes to lung injury in experimental animals and bronchopulmonary dysplasia (BPD) in preterm infants. Cytochrome P4501A (CYP1A) enzymes, which are regulated by the aryl hydrocarbon receptor (AhR), have be...
- AZD9668: Pharmacological Characterization of a Novel Oral Inhibitor of Neutrophil Elastase
[作者:Stevens, T; Ekholm, K; Granse, M; Lindahl, M; Kozma, V; Jungar, C; Ottosson, T; Falk-Hakansson, H; Churg, A; Wright, JL; Lal, H; Sanfridson, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:313-320 , 文章类型: Article,,卷期:2011年339-1]
- N-{[5-(methanesulfonyl)pyridin-2-yl]methyl}-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-[3-(trifluoromethyl) phenyl]-1,2-dihydropyridine-3-carboxamide (AZD9668) is a novel, oral inhibitor of neutrophil elastase (NE), a...
- Facilitation of Hippocampal Synaptogenesis and Spatial Memory by C-Terminal Truncated Nle(1)-Angiotensin IV Analogs
[作者:Benoist, CC; Wright, JW; Zhu, MY; Appleyard, SM; Wayman, GA; Harding, JW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:35-44 , 文章类型: Article,,卷期:2011年339-1]
- Angiotensin IV (AngIV; Val(1)-Tyr(2)-Ile(3)-His(4)-Pro(5)-Phe(6))-related peptides have emerged as potential antidementia agents. However, their development as practical therapeutic agents has been impeded by a combinati...
- Pharmacologic Inhibition of Ghrelin Receptor Signaling Is Insulin Sparing and Promotes Insulin Sensitivity
[作者:Longo, KA; Govek, EK; Nolan, A; McDonagh, T; Charoenthongtrakul, S; Giuliana, DJ; Morgan, K; Hixon, J; Zhou, CS; Kelder, B; Kopchick, JJ; Saunders, JO; Navia, MA; Curtis, R; DiStefano, PS; Geddes, BJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:115-124 , 文章类型: Article,,卷期:2011年339-1]
- Ghrelin influences a variety of metabolic functions through a direct action at its receptor, the GhrR (GhrR-1a). Ghrelin knockout (KO) and GhrR KO mice are resistant to the negative effects of high-fat diet (HFD) feeding...
- Varenicline Is a Potent Agonist of the Human 5-Hydroxytryptamine(3) Receptor
[作者:Lummis, SCR; Thompson, AJ; Bencherif, M; Lester, HA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:125-131 , 文章类型: Article,,卷期:2011年339-1]
- Varenicline, a widely used and successful smoking cessation agent, acts as a partial agonist at nicotinic acetylcholine receptors. Here, we explore the effects of varenicline at human and mouse 5-Hydroxytryptamine(3) (5-...
- Drug Targeting to Monocytes and Macrophages Using Esterase-Sensitive Chemical Motifs
[作者:Needham, LA; Davidson, AH; Bawden, LJ; Belfield, A; Bone, EA; Brotherton, DH; Bryant, S; Charlton, MH; Clark, VL; Davies, SJ; Donald, A; Day, FA; Krige, D; Legris, V; McDermott, J; McGovern, Y; Owen, J; Patel, SR; Pintat, S; Testar, RJ; Wells, GMA; Moffat, D; Drummond, AH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:132-142 , 文章类型: Article,,卷期:2011年339-1]
- The therapeutic and toxic effects of drugs are often generated through effects on distinct cell types in the body. Selective delivery of drugs to specific cells or cell lineages would, therefore, have major advantages, i...
- A Clopidogrel-Insensitive Inducible Pool of P2Y(12) Receptors Contributes to Thrombus Formation: Inhibition by Elinogrel, a Direct-Acting, Reversible P2Y(12) Antagonist
[作者:Haberstock-Debic, H; Andre, P; Mills, S; Phillips, DR; Conley, PB,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:54-61 , 文章类型: Article,,卷期:2011年339-1]
- It is known that hepatic metabolism limits the antiaggregatory activity of clopidogrel and, as a consequence, its clinical benefits. In this study, we investigated whether other factors exist that could account for clopi...
- Generation and Characterization of a Cyp2f2-Null Mouse and Studies on the Role of CYP2F2 in Naphthalene-Induced Toxicity in the Lung and Nasal Olfactory Mucosa
[作者:Li, L; Wei, Y; Van Winkle, L; Zhang, QY; Zhou, X; Hu, JP; Xie, F; Kluetzman, K; Ding, XX,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:62-71 , 文章类型: Article,,卷期:2011年339-1]
- The CYP2F enzymes, abundantly expressed in the respiratory tract, are active toward many xenobiotic compounds, including naphthalene (NA). However, the precise roles of these enzymes in tissue-selective chemical toxicity...
- Distinct Effects of Imperatorin on Allergic Rhinitis: Imperatorin Inhibits Caspase-1 Activity In Vivo and In Vitro
[作者:Oh, HA; Kim, HM; Jeong, HJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:72-81 , 文章类型: Article,,卷期:2011年339-1]
- Because imperatorin (IPT), the furanocoumarins exhibits anti-inflammatory activity, we reasoned that IPT might modulate the allergic rhinitis (AR). The aim of this study was to analyze the regulation of AR by IPT. Here, ...
- Chymase Inhibition Reduces Infarction and Matrix Metalloproteinase-9 Activation and Attenuates Inflammation and Fibrosis after Acute Myocardial Ischemia/Reperfusion
[作者:Oyamada, S; Bianchi, C; Takai, S; Chu, LM; Sellke, FW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:143-151 , 文章类型: Article,,卷期:2011年339-1]
- Chymase is activated after acute myocardial ischemia/reperfusion (AMI-R) and is associated with an early activation of matrix metalloproteinase-9 (MMP-9), which increases infarct size after experimental AMI, and late fib...
- Afobazole Modulates Microglial Function via Activation of Both sigma-1 and sigma-2 Receptors
[作者:Cuevas, J; Rodriguez, A; Behensky, A; Katnik, C,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:161-172 , 文章类型: Article,,卷期:2011年339-1]
- Microglial cells play a critical role in the neuroinflammatory response that accompanies various diseases of the central nervous system, such as ischemic stroke, and ATP is a major signaling molecule regulating the respo...
|