- Effect of Ser-129 Phosphorylation on Interaction of alpha-Synuclein with Synaptic and Cellular Membranes
[作者:Visanji, NP; Wislet-Gendebien, S; Oschipok, LW; Zhang, G; Aubert, I; Fraser, PE; Tandon, A,期刊:Journal of Biological Chemistry, 页码:35863-35873 , 文章类型: Article,,卷期:2011年286-41]
- Background: The majority of alpha-synuclein is phosphorylated at serine 129 in Lewy bodies. Results: The membrane association of PD-linked mutant alpha-synuclein, but not wild-type alpha-synuclein, was increased by serin...
- Interaction Patches of Procaspase-1 Caspase Recruitment Domains (CARDs) Are Differently Involved in Procaspase-1 Activation and Receptor-interacting Protein 2 (RIP2)-dependent Nuclear Factor kappa B Signaling
[作者:Kersse, K; Lamkanfi, M; Bertrand, MJM; Berghe, TV; Vandenabeele, P,期刊:Journal of Biological Chemistry, 页码:35874-35882 , 文章类型: Article,,卷期:2011年286-41]
- Background: The CARD of procaspase-1 regulates activation of procaspase-1 and NF-kappa B. Results: We show that the CARD procaspase-1 interacts with ASC through a type I interaction, whereas RIP2-mediated NF-kappa B acti...
- Polo-like Kinase 1 Facilitates Loss of Pten Tumor Suppressor-induced Prostate Cancer Formation
[作者:Liu, XS; Song, B; Elzey, BD; Ratliff, TL; Konieczny, SF; Cheng, L; Ahmad, N; Liu, XQ,期刊:Journal of Biological Chemistry, 页码:35795-35800 , 文章类型: Article,,卷期:2011年286-41]
- Background: Loss of Pten is thought to mediate the majority of prostate cancers. Results: Polo-like kinase 1 confers the tumorigenic competence of Pten-deleted prostate cancer cells. Conclusion: Polo-like kinase 1 facili...
- The Identification of a Novel Protein Involved in Molybdenum Cofactor Biosynthesis in Escherichia coli
[作者:Dahl, JU; Urban, A; Bolte, A; Sriyabhaya, P; Donahue, JL; Nimtz, M; Larson, TJ; Leimkuhler, S,期刊:Journal of Biological Chemistry, 页码:35801-35812 , 文章类型: Article,,卷期:2011年286-41]
- Background: In Moco biosynthesis, sulfur is transferred from L-cysteine to MPT synthase, catalyzing the conversion of cPMP to MPT. Results: The rhodanese-like protein YnjE is a novel protein involved in Moco biosynthesis...
- Comparative Structural and Molecular Characterization of Streptococcus pneumoniae Capsular Polysaccharide Serogroup 10
[作者:Yang, JH; Nahm, MH; Bush, CA; Cisar, JO,期刊:Journal of Biological Chemistry, 页码:35813-35822 , 文章类型: Article,,卷期:2011年286-41]
- Streptococcus pneumoniae serogroup 10 includes four cross-reactive capsular polysaccharide (CPS) serotypes (10F, 10A, 10B, and 10C). In the present study, the structures of CPS10B and CPS10C were determined by chemical a...
- High Cell Surface Death Receptor Expression Determines Type I Versus Type II Signaling
[作者:Meng, XW; Peterson, KL; Dai, HM; Schneider, P; Lee, SH; Zhang, JS; Koenig, A; Bronk, S; Billadeau, DD; Gores, GJ; Kaufmann, SH,期刊:Journal of Biological Chemistry, 页码:35823-35833 , 文章类型: Article,,卷期:2011年286-41]
- Previous studies have suggested that there are two signaling pathways leading from ligation of the Fas receptor to induction of apoptosis. Type I signaling involves Fas ligand-induced recruitment of large amounts of FADD...
- Cellular Iron Depletion and the Mechanisms Involved in the Iron-dependent Regulation of the Growth Arrest and DNA Damage Family of Genes
[作者:Saletta, F; Rahmanto, YS; Siafakas, AR; Richardson, DR,期刊:Journal of Biological Chemistry, 页码:35396-35406 , 文章类型: Article,,卷期:2011年286-41]
- Iron plays a crucial part in proliferation while iron deficiency results in G(1)/S arrest, DNA damage, and apoptosis. However, the precise role of iron in cell cycle control remains unclear. We showed that iron depletion...
- Glutathione Peroxidase-1 Deficiency Augments Proinflammatory Cytokine-induced Redox Signaling and Human Endothelial Cell Activation
[作者:Lubos, E; Kelly, NJ; Oldebeken, SR; Leopold, JA; Zhang, YY; Loscalzo, J; Handy, DE,期刊:Journal of Biological Chemistry, 页码:35407-35417 , 文章类型: Article,,卷期:2011年286-41]
- Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant enzyme, the deficiency of which promotes atherogenesis. Accordingly, we examined the mechanisms by which GPx-1 deficiency enhances endothelial cell activation and...
- Senescence-associated Barley NAC (NAM, ATAF1,2, CUC) Transcription Factor Interacts with Radical-induced Cell Death 1 through a Disordered Regulatory Domain
[作者:Kjaersgaard, T; Jensen, MK; Christiansen, MW; Gregersen, P; Kragelund, BB; Skriver, K,期刊:Journal of Biological Chemistry, 页码:35418-35429 , 文章类型: Article,,卷期:2011年286-41]
- Senescence in plants involves massive nutrient relocation and age-related cell death. Characterization of the molecular components, such as transcription factors (TFs), involved in these processes is required to understa...
- Platelet-derived Growth Factor (PDGF) Regulates Slingshot Phosphatase Activity via Nox1-dependent Auto-dephosphorylation of Serine 834 in Vascular Smooth Muscle Cells
[作者:Maheswaranathan, M; Gole, HKA; Fernandez, I; Lassegue, B; Griendling, KK; San Martin, A,期刊:Journal of Biological Chemistry, 页码:35430-35437 , 文章类型: Article,,卷期:2011年286-41]
- Migration of vascular smooth muscle cells (VSMCs) contributes to vascular pathology. PDGF induces VSMC migration by a Nox1-based NADPH oxidase mediated mechanism. We have previously shown that PDGF-induced migration in V...
- Structural Differences in Lipomannans from Pathogenic and Nonpathogenic Mycobacteria That Impact CD1b-restricted T Cell Responses
[作者:Torrelles, JB; Sieling, PA; Arcos, J; Knaup, R; Bartling, C; Rajaram, MVS; Stenger, S; Modlin, RL; Schlesinger, LS,期刊:Journal of Biological Chemistry, 页码:35438-35446 , 文章类型: Article,,卷期:2011年286-41]
- Mannosylated molecules on the Mycobacterium tuberculosis surface are important determinants in the immunopathogenesis of tuberculosis. To date, much attention has been paid to mannose-capped lipoarabinomannan, which medi...
- Chitosan but Not Chitin Activates the Inflammasome by a Mechanism Dependent upon Phagocytosis
[作者:Bueter, CL; Lee, CK; Rathinam, VAK; Healy, GJ; Taron, CH; Specht, CA; Levitz, SM,期刊:Journal of Biological Chemistry, 页码:35447-35455 , 文章类型: Article,,卷期:2011年286-41]
- Chitin is an abundant polysaccharide found in fungal cell walls, crustacean shells, and insect exoskeletons. The immunological properties of both chitin and its deacetylated derivative chitosan are of relevance because o...
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