- Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut
[作者:Joseph, NM; He, SH; Quintana, E; Kim, YG; Nunez, G; Morrison, SJ,期刊:Journal of clinical investigation, 页码:3398-3411 , 文章类型: Article,,卷期:2011年121-9]
- It is unclear whether neurogenesis occurs in the adult mammalian enteric nervous system (ENS). Neural crest-derived cells capable of forming multilineage colonies in culture, and neurons and glia upon transplantation int...
- Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury
[作者:Laranjeira, C; Sandgren, K; Kessaris, N; Richardson, W; Potocnik, A; Berghe, PV; Pachnis, V,期刊:Journal of clinical investigation, 页码:3412-3424 , 文章类型: Article,,卷期:2011年121-9]
- The enteric nervous system (ENS) in mammals forms from neural crest cells during embryogenesis and early postnatal life. Nevertheless, multipotent progenitors of the ENS can be identified in the adult intestine using clo...
- miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans
[作者:Chen, PS; Su, JL; Cha, ST; Tarn, WY; Wang, MY; Hsu, HC; Lin, MT; Chu, CY; Hua, KT; Chen, CN; Kuo, TC; Chang, KJ; Hsiao, M; Chang, YW; Chen, JS; Yang, PC; Kuo, ML,期刊:Journal of clinical investigation, 页码:3442-3455 , 文章类型: Article,,卷期:2011年121-9]
- MicroRNAs (miRNAs) influence many biological processes, including cancer. They do so by posttranscriptionally repressing target mRNAs to which they have sequence complementarity. Although it has been postulated that miRN...
- Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis
[作者:Goertz, MJ; Wu, ZR; Gallardo, TD; Hamra, FK; Castrillon, DH,期刊:Journal of clinical investigation, 页码:3456-3466 , 文章类型: Article,,卷期:2011年121-9]
- Spermatogonial stem cells (SSCs) capable of self-renewal and differentiation are the foundation for spermatogenesis. Although several factors important for these processes have been identified, the fundamental mechanisms...
- Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans
[作者:Ngan, ESW; Garcia-Barcelo, MM; Yip, BHK; Poon, HC; Lau, ST; Kwok, CKM; Sat, E; Sham, MH; Wong, KKY; Wainwright, BJ; Cherny, SS; Hui, CC; Sham, PC; Lui, VCH; Tam, PKH,期刊:Journal of clinical investigation, 页码:3467-3478 , 文章类型: Article,,卷期:2011年121-9]
- Hirschsprung (HSCR) disease is a complex genetic disorder attributed to a failure of the enteric neural crest cells (ENCCs) to form ganglia in the hindgut. Hedgehog and Notch are implicated in mediating proliferation and...
- Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice
[作者:Kraft, M; Cirstea, IC; Voss, AK; Thomas, T; Goehring, I; Sheikh, BN; Gordon, L; Scott, H; Smyth, GK; Ahmadian, MR; Trautmann, U; Zenker, M; Tartaglia, M; Ekici, A; Reis, A; Dorr, HG; Rauch, A; Thiel, CT,期刊:Journal of clinical investigation, 页码:3479-3491 , 文章类型: Article,,卷期:2011年121-9]
- Epigenetic regulation of gene expression, through covalent modification of histones, is a key process controlling growth and development. Accordingly, the transcription factors regulating these processes are important ta...
- G(s)alpha enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice
[作者:Wu, JY; Aarnisalo, P; Bastepe, M; Sinha, P; Fulzele, K; Selig, MK; Chen, M; Poulton, IJ; Purton, LE; Sims, NA; Weinstein, LS; Kronenberg, HM,期刊:Journal of clinical investigation, 页码:3492-3504 , 文章类型: Article,,卷期:2011年121-9]
- The heterotrimeric G protein subunit G(s)alpha stimulates cAMP-dependent signaling downstream of G protein-coupled receptors. In this study, we set out to determine the role of G(s)alpha signaling in cells of the early o...
- OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice
[作者:Barrow, AD; Raynal, N; Andersen, TL; Slatter, DA; Bihan, D; Pugh, N; Cella, M; Kim, T; Rho, J; Negishi-Koga, T; Delaisse, JM; Takayanagi, H; Lorenzo, J; Colonna, M; Farndale, RW; Choi, Y; Trowsdale, J,期刊:Journal of clinical investigation, 页码:3505-3516 , 文章类型: Article,,卷期:2011年121-9]
- Osteoclasts are terminally differentiated leukocytes that erode the mineralized bone matrix. Osteoclastogenesis requires costimulatory receptor signaling through adaptors containing immunoreceptor tyrosine-based activati...
- Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis
[作者:Song, JJ; Hwang, I; Cho, KH; Garcia, MA; Kim, AJ; Wang, TH; Lindstrom, TM; Lee, AT; Nishimura, T; Zhao, L; Morser, J; Nesheim, M; Goodman, SB; Lee, DM; Bridges, SL; Gregersen, PK; Leung, LL; Robinson, WH,期刊:Journal of clinical investigation, 页码:3517-3527 , 文章类型: Article,,卷期:2011年121-9]
- The immune and coagulation systems are both implicated in the pathogenesis of rheumatoid arthritis (RA). Plasma carboxypeptidase B (CPB), which is activated by the thrombin/thrombomodulin complex, plays a procoagulant ro...
- Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma
[作者:Zode, GS; Kuehn, MH; Nishimura, DY; Searby, CC; Mohan, K; Grozdanic, SD; Bugge, K; Anderson, MG; Clark, AF; Stone, EM; Sheffield, VC,期刊:Journal of clinical investigation, 页码:3542-3553 , 文章类型: Article,,卷期:2011年121-9]
- Mutations in myocilin (MYOC) are the most common genetic cause of primary open angle glaucoma (POAG), but the mechanisms underlying MYOC-associated glaucoma are not fully understood. Here, we report the development of a ...
- Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection
[作者:Renna, M; Schaffner, C; Brown, K; Shang, SB; Tamayo, MH; Hegyi, K; Grimsey, NJ; Cusens, D; Coulter, S; Cooper, J; Bowden, AR; Newton, SM; Kampmann, B; Helm, J; Jones, A; Haworth, CS; Basaraba, RJ; DeGroote, MA; Ordway, DJ; Rubinsztein, DC; Floto, RA,期刊:Journal of clinical investigation, 页码:3554-3563 , 文章类型: Article,,卷期:2011年121-9]
- Azithromycin is a potent macrolide antibiotic with poorly understood antiinflammatory properties. Longterm use of azithromycin in patients with chronic inflammatory lung diseases, such as cystic fibrosis (CF), results in...
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