- Excess polycation mediates efficient chitosan-based gene transfer by promoting lysosomal release of the polyplexes
[作者:Thibault, M; Astolfi, M; Tran-Khanh, N; Lavertu, M; Darras, V; Merzouki, A; Buschmann, MD,期刊:BIOMATERIALS, 页码:4639-4646 , 文章类型: Article,,卷期:2011年32-20]
- The optimal ratio of the polycation's amine to DNA phosphate group (N:P) for efficient polymer-based transfection always employs excess polycation versus DNA. Most of the excess polycation remains free in solution, unass...
- Efficient gene delivery of primary human cells using peptide linked polyethylenimine polymer hybrid
[作者:Dey, D; Inayathullah, M; Lee, AS; LeMieux, MC; Zhang, XX; Wu, Y; Nag, D; De Almeida, PE; Han, L; Rajadas, J; Wu, JC,期刊:BIOMATERIALS, 页码:4647-4658 , 文章类型: Article,,卷期:2011年32-20]
- Polyethylenimine (PEI) based polymers are efficient agents for cell transfection. However, their use has been hampered due to high cell death associated with transfection thereby resulting in low efficiency of gene deliv...
- The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose-modified lipoplexes
[作者:Un, K; Kawakami, S; Yoshida, M; Higuchi, Y; Suzuki, R; Maruyama, K; Yamashita, F; Hashida, M,期刊:BIOMATERIALS, 页码:4659-4669 , 文章类型: Article,,卷期:2011年32-20]
- The development of gene transfection methods enhancing the level of gene expression under simple and low-toxic condition is required for gene therapy in clinical. Our group has developed the ultrasound (US)mediated gene ...
- The viscoelastic, hyperelastic and scale dependent behaviour of freshly excised individual skin layers
[作者:Crichton, ML; Donose, BC; Chen, XF; Raphael, AP; Huang, H; Kendall, MAF,期刊:BIOMATERIALS, 页码:4670-4681 , 文章类型: Article,,卷期:2011年32-20]
- Micro-devices using mechanical means to target skin for improved drug and vaccine delivery have great promise for improved clinical healthcare. Fully realizing this promise requires a greater understanding of key micro-b...
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