- A new pathway that regulates 53BP1 stability implicates Cathepsin L and vitamin D in DNA repair
[作者:Gonzalez-Suarez, I; Redwood, AB; Grotsky, DA; Neumann, MA; Cheng, EHY; Stewart, CL; Dusso, A; Gonzalo, S,期刊:EMBO journal, 页码:3383-3396 , 文章类型: Article,,卷期:2011年30-16]
- Genomic instability due to telomere dysfunction and defective repair of DNA double-strand breaks (DSBs) is an underlying cause of ageing-related diseases. 53BP1 is a key factor in DNA DSBs repair and its deficiency is as...
- p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death
[作者:Feng, X; Liu, X; Zhang, W; Xiao, WH,期刊:EMBO journal, 页码:3397-3415 , 文章类型: Article,,卷期:2011年30-16]
- Hypoxia stabilizes the tumour suppressor p53, allowing it to function primarily as a transrepressor; however, the function of p53 during hypoxia remains unclear. In this study, we showed that p53 suppressed BNIP3 express...
- Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility
[作者:Sun, FN; Zhu, CM; Dixit, R; Cavalli, V,期刊:EMBO journal, 页码:3416-3429 , 文章类型: Article,,卷期:2011年30-16]
- Neuronal development, function and repair critically depend on axonal transport of vesicles and protein complexes, which is mediated in part by the molecular motor kinesin-1. Adaptor proteins recruit kinesin-1 to vesicle...
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