Several novel multicomponent assembly processes have been developed for the rapid and efficient assembly of various heterocyclic scaffolds bearing a tetrahydroisoquinoline core, each of which allows for facile derivatiza...
Natural substances such as pelletierine and its analogues have been prepared in up to 97% ee and good yield by a protective-group-free, biomimetic approach. Usage of benzonitrile or acetonitrile as solvents effectively p...
(+/-)-Dibromophakellin has been synthesized in two steps from a known alkene intermediate. The key step in the synthesis is the NBS olefin activation to facilitate the addition of a guanidine molecule across the double b...
The first enantioselective synthesis of (-)-jiadifenin (1), a potent neurite outgrowth promoter isolated from the illicium species, is described. The synthetic strategy builds upon bicyclic motif 6, which represents the ...
A cholesterol-conjugated fluorescence Zn(2+) sensor based on the fluorescein platform was designed and synthesized. The cholesterol moiety is essential for localizing the Zn(2+) sensor to the cell membrane, allowing the ...
A titanacarborane monoamide catalyzed, one-step synthesis of mono/bicyclic guanidines from commercially available di/triamines and carbodiimides is reported. The reaction mechanism is also proposed.
Enabled by the broad scope of the Pd-catalyzed asymmetric alkylation of meso- and d,l-divinylethylene carbonate, several chiral diene ligands were prepared in two steps from commercial materials. Subsequently, these liga...
6-O-Modified beta-cyclodextrins, such as heptakis(6-O-triisopropylsilyl)-beta-cyclodextrin (TIPS-beta-CD) and heptakis(6-O-tert-butyldimethylsilyl)-beta-cyclodextrin (TBDMS-beta-CD), formed 2:1 Inclusion complexes with p...
Hexylthiophene-conjugated boron-dibenzopyrromethenes with benzo[1,3,2]oxazaborinine rings, 1, that absorb near-infrared light with relatively high molecular extinction coefficients have been synthesized. The incorporatio...
Sulfamoyl azides are readily generated from secondary amines and a novel sulfonyl azide transfer agent, 2,3-dimethyl-1H-imidazolium triflate. They react with alkynes in the presence of a CuTC catalyst forming 1-sulfamoyl...
A palladium-catalyzed coupling of N-heterocycles with simple alcohols was achieved. The reaction is initiated by peroxide and does not require the use of stoichlometric acid for activation of the heterocycle.
A chemo- and enantioselective [3 + 2] annulation of Morita-Baylis-Hillman carbonates of isatins with propargyl sulfones was catalyzed by a beta-ICD O-MOM ether 1c, affording spirocyclic 2-oxindoles bearing an unusual cyc...
The development of an expedient synthesis toward quinoxaline ring-embedded polyacenoquinone esters with the generic structure A is demonstrated by the synthesis of penta- and hexacenoquinone esters. They are potential n-...
A unique route to the structural diversity of pyridone alkaloids is described based on the concept of a common synthetic strategy. Three different core structure analogues corresponding to akanthomycin, septoriamycin A, ...
The gamma-selective, palladium-catalyzed cross-coupling of sodium (2)-2-butenyidiethylsilanolate with a variety of aromatic bromides Is reported. The protocol provides high yields (73-94%) and site selectivity (gamma/alp...
A new synthetic approach toward the bacterial transglycosylase substrates, Lipid II (1) and Lipid IV (2), Is described. The key disaccharide was synthesized using the concept of relative reactivity value (RRV) and elabor...