- Mass and relative elution time profiling: two-dimensional analysis of sphingolipids in Alzheimer's disease brains
[作者:Hejazi, L; Wong, JWH; Cheng, DN; Proschogo, N; Ebrahimi, D; Garner, B; Don, AS,期刊:Biochemical Journal, 页码:165-175 , 文章类型: Article,,卷期:2011年438-Part 1]
- Current lipidomic profiling methods rely mainly on MS to identify unknown lipids within a complex sample. We describe a new approach, involving LC x MS/MS (liquid chromatography x tandem MS) analysis of sphingolipids bas...
- Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 beta-cells
[作者:Veret, J; Coant, N; Berdyshev, EV; Skobeleva, A; Therville, N; Bailbe, D; Gorshkova, I; Natarajan, V; Portha, B; Le Stunff, H,期刊:Biochemical Journal, 页码:177-189 , 文章类型: Article,,卷期:2011年438-Part 1]
- Pancreatic beta-cell apoptosis induced by palmitate requires high glucose concentrations. Ceraraides have been suggested to be important mediators of glucolipotoxicity-induced beta-cell apoptosis. In INS-1 beta-cells, 0....
- Arachidonic acid modulates Na+ currents by non-metabolic and metabolic pathways in rat cerebellar granule cells
[作者:Fang, YJ; Zhou, MH; Gao, XF; Gu, H; Mei, YA,期刊:Biochemical Journal, 页码:203-215 , 文章类型: Article,,卷期:2011年438-Part 1]
- AA (arachidonic acid), which possesses both neurotoxic and neurotrophic activities, has been implicated as a messenger in both physiological and pathophysiological processes. In the present study, we investigated the eff...
- Translation initiation factors and active sites of protein synthesis co-localize at the leading edge of migrating fibroblasts
[作者:Willett, M; Brocard, M; Davide, A; Morley, SJ,期刊:Biochemical Journal, 页码:217-227 , 文章类型: Article,,卷期:2011年438-Part 1]
- Cell migration is a highly controlled essential cellular process, often dysregulated in tumour cells, dynamically controlled by the architecture of the cell. Studies involving cellular fractionation and microarray profil...
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