- Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection
[作者:Jones, D; Glimcher, LH; Aliprantis, AO,期刊:Journal of clinical investigation, 页码:2534-2542 , 文章类型: Article,,卷期:2011年121-7]
- Over the past decade and a half, the biomedical community has uncovered a previously unappreciated reciprocal relationship between cells of the immune and skeletal systems. Work in this field, which has been termed "oste...
- Loss of Gata5 in mice leads to bicuspid aortic valve
[作者:Laforest, B; Andelfinger, G; Nemer, M,期刊:Journal of clinical investigation, 页码:2876-2887 , 文章类型: Article,,卷期:2011年121-7]
- Bicuspid aortic valve (BAV), the leading congenital heart disease, occurs in 1%-2% of the population. Genetic studies suggest that BAV is an autosomal-dominant disease with reduced penetrance. However, only 1 gene, NOTCH...
- Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics
[作者:Dafinger, C; Liebau, MC; Elsayed, SM; Hellenbroich, Y; Boltshauser, E; Korenke, GC; Fabretti, F; Janecke, AR; Ebermann, I; Nurnberg, G; Nurnberg, P; Zentgraf, H; Koerber, F; Addicks, K; Elsobky, E; Benzing, T; Schermer, B; Bolz, HJ,期刊:Journal of clinical investigation, 页码:2662-2667 , 文章类型: Article,,卷期:2011年121-7]
- Joubert syndrome (JBTS) is characterized by a specific brain malformation with various additional pathologies. It results from mutations in any one of at least 10 different genes, including NPHP1, which encodes nephrocys...
- Myeloid-derived suppressor cells are implicated in regulating permissiveness for tumor metastasis during mouse gestation
[作者:Mauti, LA; Le Bitoux, MA; Baumer, K; Stehle, JC; Golshayan, D; Provero, P; Stamenkovic, I,期刊:Journal of clinical investigation, 页码:2794-2807 , 文章类型: Article,,卷期:2011年121-7]
- Metastasis depends on the ability of tumor cells to establish a relationship with the newly seeded tissue that is conducive to their survival and proliferation. However, the factors that render tissues permissive for met...
- Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
[作者:Rayner, KJ; Sheedy, FJ; Esau, CC; Hussain, FN; Temel, RE; Parathath, S; van Gils, JM; Rayner, AJ; Chang, AN; Suarez, Y; Fernandez-Hernando, C; Fisher, EA; Moore, KJ,期刊:Journal of clinical investigation, 页码:2921-2931 , 文章类型: Article,,卷期:2011年121-7]
- Plasma HDL levels have a protective role in atherosclerosis, yet clinical therapies to raise HDL levels have remained elusive. Recent advances in the understanding of lipid metabolism have revealed that miR-33, an intron...
- P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice
[作者:Furlan-Freguia, C; Marchese, P; Gruber, A; Ruggeri, ZM; Ruf, W,期刊:Journal of clinical investigation, 页码:2932-2944 , 文章类型: Article,,卷期:2011年121-7]
- Thrombosis is initiated by tissue factor (TF), a coagulation cofactor/receptor expressed in the vessel wall, on myeloid cells, and on microparticles (MPs) with variable procoagulant activity. However, the molecular pathw...
- Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
[作者:Cao, K; Blair, CD; Faddah, DA; Kieckhaefer, JE; Olive, M; Erdos, MR; Nabel, EG; Collins, FS,期刊:Journal of clinical investigation, 页码:2833-2844 , 文章类型: Article,,卷期:2011年121-7]
- Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disease, is caused by a point mutation in the lamin A gene (LMNA). This mutation constitutively activates a cryptic splice donor site, resulting ...
- Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes
[作者:Stein, AB; Jones, TA; Herron, TJ; Patel, SR; Day, SM; Noujaim, SF; Milstein, ML; Klos, M; Furspan, PB; Jalife, J; Dressler, GR,期刊:Journal of clinical investigation, 页码:2641-2650 , 文章类型: Article,,卷期:2011年121-7]
- Histone H3 lysine 4 (H3K4me) methyltransferases and their cofactors are essential for embryonic development and the establishment of gene expression patterns in a cell-specific and heritable manner. However, the importan...
- FGF-dependent regulation of VEGF receptor 2 expression in mice
[作者:Murakami, M; Nguyen, LT; Hatanaka, K; Schachterle, W; Chen, PY; Zhuang, ZW; Black, BL; Simons, M,期刊:Journal of clinical investigation, 页码:2668-2678 , 文章类型: Article,,卷期:2011年121-7]
- Numerous studies have suggested a link between the angiogenic FGF and VEGF signaling pathways; however, the nature of this link has not been established. To evaluate this relationship, we investigated VEGF signaling in E...
- Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
[作者:Lehmann, BD; Bauer, JA; Chen, X; Sanders, ME; Chakravarthy, AB; Shyr, Y; Pietenpol, JA,期刊:Journal of clinical investigation, 页码:2750-2767 , 文章类型: Article,,卷期:2011年121-7]
- Triple-negative breast cancer (TNBC) is a highly diverse group of cancers, and subtyping is necessary to better identify molecular-based therapies. In this study, we analyzed gene expression (GE) profiles from 21 breast ...
- Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice (vol 120, pg 2684, 2010)
[作者:Casazza, A; Finisguerra, V; Capparuccia, L; Camperi, A; Swiercz, JM; Rizzolio, S; Rolny, C; Christensen, C; Bertotti, A; Sarotto, I; Risio, M; Trusolino, L; Weitz, J; Schneider, M; Mazzone, M; Comoglio, PM; Tamagnone, L,期刊:Journal of clinical investigation, 页码:2945-2945 , 文章类型: Correction,,卷期:2011年121-7]
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- Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease
[作者:Besler, C; Heinrich, K; Rohrer, L; Doerries, C; Riwanto, M; Shih, DM; Chroni, A; Yonekawa, K; Stein, S; Schaefer, N; Mueller, M; Akhmedov, A; Daniil, G; Manes, C; Templin, C; Wyss, C; Maier, W; Tanner, FC; Matter, CM; Corti, R; Furlong, C; Lusis, AJ; von Eckardstein, A; Fogelman, AM; Luscher, TF; Landmesser, U,期刊:Journal of clinical investigation, 页码:2693-2708 , 文章类型: Article,,卷期:2011年121-7]
- Therapies that raise levels of HDL, which is thought to exert atheroprotective effects via effects on endothelium, are being examined for the treatment or prevention of coronary artery disease (CAD). However, the endothe...
- Attenuation of HIV-associated human B cell exhaustion by siRNA down regulation of inhibitory receptors
[作者:Kardava, L; Moir, S; Wang, W; Ho, J; Buckner, CM; Posada, JG; O'Shea, MA; Roby, G; Chen, J; Sohn, HW; Chun, TW; Pierce, SK; Fauci, AS,期刊:Journal of clinical investigation, 页码:2614-2624 , 文章类型: Article,,卷期:2011年121-7]
- Chronic immune activation in HIV-infected individuals leads to accumulation of exhausted tissue-like memory B cells. Exhausted lymphocytes display increased expression of multiple inhibitory receptors, which may contribu...
- Integrin alpha 6 beta 4 identifies an adult distal lung epithelial population with regenerative potential in mice
[作者:Chapman, HA; Li, XP; Alexander, JP; Brumwel, A; Lorizio, W; Tan, K; Sonnenberg, A; Wei, Y; Vu, TH,期刊:Journal of clinical investigation, 页码:2855-2862 , 文章类型: Article,,卷期:2011年121-7]
- Laminins and their integrin receptors are implicated in epithelial cell differentiation and progenitor cell maintenance. We report here that a previously unrecognized subpopulation of mouse alveolar epithelial cells (AEC...
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