- APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP
[作者：Weyer, SW; Klevanski, M; Delekate, A; Voikar, V; Aydin, D; Hick, M; Filippov, M; Drost, N; Schaller, KL; Saar, M; Vogt, MA; Gass, P; Samanta, A; Jaschke, A; Korte, M; Wolfer, DP; Caldwell, JH; Muller, UC,期刊：EMBO journal, 页码：2266-2280 , 文章类型： Article，,卷期：2011年30-11]
- Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid precursor protein (APP) and its proteolytic fragments are still poorly understood. Previously, we generated APPs alpha knock-in...
- MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development
[作者：Jin, GX; Zhang, FJ; Chan, KM; Wong, HLX; Liu, BH; Cheah, KSE; Liu, XG; Mauch, C; Liu, DP; Zhou, ZJ,期刊：EMBO journal, 页码：2281-2293 , 文章类型： Article，,卷期：2011年30-11]
- Notch signalling controls the differentiation of haematopoietic progenitor cells (HPCs). Here, we show that loss of membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP14), a cell surface protease expressed in bone mar...
- Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis
[作者：Aspeslagh, S; Li, YL; Yu, ED; Pauwels, N; Trappeniers, M; Girardi, E; Decruy, T; Van Beneden, K; Venken, K; Drennan, M; Leybaert, L; Wang, J; Franck, RW; Van Calenbergh, S; Zajonc, DM; Elewaut, D,期刊：EMBO journal, 页码：2294-2305 , 文章类型： Article，,卷期：2011年30-11]
- Invariant natural killer T (iNKT) cells are known to have marked immunomodulatory capacity due to their ability to produce copious amounts of effector cytokines. Here, we report the structure and function of a novel clas...
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