- Genetic Defect in Phospholipase C delta 1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis
[作者:Hirata, M; Suzuki, M; Ishii, R; Satow, R; Uchida, T; Kitazumi, T; Sasaki, T; Kitamura, T; Yamaguchi, H; Nakamura, Y; Fukami, K,期刊:Diabetes, 页码:1926-1937 , 文章类型: Article,,卷期:2011年60-7]
- OBJECTIVE-Regulation of obesity development is an important issue to prevent metabolic syndromes. Gene-disrupted mice of phospholipase C delta 1 (PLC delta 1), a key enzyme of phosphoinositide turnover, seemed to show le...
- Body Weight, Not Insulin Sensitivity or Secretion, May Predict Spontaneous Weight Changes in Nondiabetic and Prediabetic Subjects The RISC Study
[作者:Rebelos, E; Muscelli, E; Natali, A; Balkau, B; Mingrone, G; Piatti, P; Konrad, T; Mari, A; Ferrannini, E,期刊:Diabetes, 页码:1938-1945 , 文章类型: Article,,卷期:2011年60-7]
- OBJECTIVE-Previous studies have found that high insulin sensitivity predicts weight gain; this association has not been confirmed. Our aim was to systematically analyze metabolic predictors of spontaneous weight changes....
- Thrombospondin-1: An Islet Endothelial Cell Signal of Importance for beta-Cell Function
[作者:Olerud, J; Mokhtari, D; Johansson, M; Christoffersson, G; Lawler, J; Welsh, N; Carlsson, PO,期刊:Diabetes, 页码:1946-1954 , 文章类型: Article,,卷期:2011年60-7]
- OBJECTIVE-Loss of thrombospondin (TSP)-1 in pancreatic islets has been shown to cause islet hyperplasia. This study tested the hypothesis that endothelial-derived TSP-1 is important for beta-cell function. RESEARCH DESIG...
- The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function
[作者:Gerold, KD; Zheng, PL; Rainbow, DB; Zernecke, A; Wicker, LS; Kissler, S,期刊:Diabetes, 页码:1955-1963 , 文章类型: Article,,卷期:2011年60-7]
- OBJECTIVE-CTLA4 gene variation associates with multiple autoimmune disorders, including type 1 diabetes. The CTLA4 susceptibility allele was found to generate decreased levels of mRNA encoding soluble CTLA-4 (sCTLA-4) re...
- Activation of Peroxisome Proliferator-Activated Receptor-beta/-delta (PPAR-beta/-delta) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleuldn-6 Stimulated Adipocytes
[作者:Serrano-Marco, L; Rodriguez-Calvo, R; El Kochairi, I; Palomer, X; Michalik, L; Wahli, W; Vazquez-Carrera, M,期刊:Diabetes, 页码:1990-1999 , 文章类型: Article,,卷期:2011年60-7]
- OBJECTIVE-It has been suggested that interleukin (IL)-6 is one of the mediators linking obesity-derived chronic inflammation with insulin resistance through activation of STAT3, with subsequent upregulation of suppressor...
- Impaired Insulin Secretion and Enhanced Insulin Sensitivity in Cholecystokinin-Deficient Mice
[作者:Lo, CM; Obici, S; Dong, HH; Haas, M; Lou, DW; Kim, DH; Liu, M; D'Alessio, D; Woods, SC; Tso, P,期刊:Diabetes, 页码:2000-2007 , 文章类型: Article,,卷期:2011年60-7]
- OBJECTIVE-Cholecystokinin (CCK) is released in response to lipid intake and stimulates insulin secretion. We hypothesized that CCK deficiency would alter the regulation of insulin secretion and glucose homeostasis. RESEA...
- Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome (vol 59, pg 3023, 2010)
[作者:Tan, BK; Adya, R; Farhatullah, S; Chen, J; Lehnert, H; Randeva, HS,期刊:Diabetes, 页码:2008-2008 , 文章类型: Correction,,卷期:2011年60-7]
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