- Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin
[作者:Heikkila, E; Ristola, M; Havana, M; Jones, N; Holthofer, H; Lehtonen, S,期刊:Biochemical Journal, 页码:619-628 , 文章类型: Article,,卷期:2011年435-Part 3]
- Slit diaphragms are specialized junctions between glomerular epithelial cells (podocytes) that are crucial for glomerular ultrafiltration. The Ig superfamily members nephrin and Neph1 are essential components of the slit...
- Inter- and intra-molecular interactions of Arabidopsis thaliana DELLA protein RGL1
[作者:Sheerin, DJ; Buchanan, J; Kirk, C; Harvey, D; Sun, X; Spagnuolo, J; Li, S; Liu, T; Woods, VA; Foster, T; Jones, WT; Rakonjac, J,期刊:Biochemical Journal, 页码:629-639 , 文章类型: Article,,卷期:2011年435-Part 3]
- The phytohormone gibberellin and the DELLA proteins act together to control key aspects of plant development. Gibberellin induces degradation of DELLA proteins by recruitment of an F-box protein using a molecular switch:...
- Galactose induction of the GAL1 gene requires conditional degradation of the Mig2 repressor
[作者:Lim, MK; Siew, WL; Zhao, J; Tay, YC; Ang, E; Lehming, N,期刊:Biochemical Journal, 页码:641-649 , 文章类型: Article,,卷期:2011年435-Part 3]
- Skp1 an essential component of the SCF (Skp1/cullin/F-box) E3 ubiquitin ligases, which target proteins for degradation by the 26S proteasome. We generated a skp1dM mutant strain that is defective for galactose induction ...
- When a module is not a domain: the case of the REJ module and the redefinition of the architecture of polycystin-1
[作者:Schroder, S; Fraternali, F; Quan, XP; Scott, D; Qian, F; Pfuhl, M,期刊:Biochemical Journal, 页码:651-660 , 文章类型: Article,,卷期:2011年435-Part 3]
- The extracellular region of a group of cell-surface receptors known as the polycystic kidney disease I family, containing, among others, polycystin-1, has been controversially described as containing four FNIII (fibronec...
- Comparing the potential renal protective activity of desferrioxamine B and the novel chelator desferrioxamine B-N-(3-hydroxyadamant-1-yl) carboxamide in a cell model of myoglobinuria
[作者:Groebler, LK; Liu, J; Shanu, A; Codd, R; Witting, PK,期刊:Biochemical Journal, 页码:669-677 , 文章类型: Article,,卷期:2011年435-Part 3]
- Accumulating Mb (myoglobin) in the kidney following severe burns promotes oxidative damage and inflammation, which leads to acute renal failure. The potential for haem iron to induce oxidative damage has prompted testing...
- Eicosanoid formation by a cytochrome P450 isoform expressed in the pharynx of Caenorhabditis elegans
[作者:Kosel, M; Wild, W; Bell, A; Rothe, M; Lindschau, C; Steinberg, CEW; Schunck, WH; Menzel, R,期刊:Biochemical Journal, 页码:689-700 , 文章类型: Article,,卷期:2011年435-Part 3]
- Caenorhabditis elegans harbours several CYP (cytochrome P450) genes that are homologous with mammalian CYP isoforms important to the production of physiologically active AA (arachidonic acid) metabolites. We tested the h...
- A(2A) adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase
[作者:Gracia, E; Perez-Capote, K; Moreno, E; Barkesova, J; Mallol, J; Lluis, C; Franco, R; Cortes, A; Casado, V; Canela, EI,期刊:Biochemical Journal, 页码:701-709 , 文章类型: Article,,卷期:2011年435-Part 3]
- A(2A)Rs (adenosine A(2A) receptors) are highly enriched in the striatum, which is the main motor control CNS (central nervous system) area. BRET (bioluminescence resonance energy transfer) assays showed that A(2A)R homom...
- Molecular interaction and functional regulation of connexin50 gap junctions by calmodulin
[作者:Chen, YY; Zhou, YB; Lin, XM; Wong, HC; Xu, Q; Jiang, J; Wang, SM; Lurtz, MM; Louis, CF; Veenstra, RD; Yang, JJ,期刊:Biochemical Journal, 页码:711-722 , 文章类型: Article,,卷期:2011年435-Part 3]
- Cx50 (connexin50), a member of the alpha-family of gap junction proteins expressed in the lens of the eye, has been shown to be essential for normal lens development. In the present study, we identified a CaMBD [CaM (cal...
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