- Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control
[作者:Kumar, C; Igbaria, A; D'autreaux, B; Planson, AG; Junot, C; Godat, E; Bachhawat, AK; Delaunay-Moisan, A; Toledano, MB,期刊:EMBO journal, 页码:2044-2056 , 文章类型: Article,,卷期:2011年30-10]
- Glutathione contributes to thiol-redox control and to extramitochondrial iron-sulphur cluster (ISC) maturation. To determine the physiological importance of these functions and sort out those that account for the GSH req...
- The cellular prion protein mediates neurotoxic signalling of beta-sheet-rich conformers independent of prion replication
[作者:Resenberger, UK; Harmeier, A; Woerner, AC; Goodman, JL; Muller, V; Krishnan, R; Vabulas, RM; Kretzschmar, HA; Lindquist, S; Hartl, FU; Multhaup, G; Winklhofer, KF; Tatzelt, J,期刊:EMBO journal, 页码:2057-2070 , 文章类型: Article,,卷期:2011年30-10]
- Formation of aberrant protein conformers is a common pathological denominator of different neurodegenerative disorders, such as Alzheimer's disease or prion diseases. Moreover, increasing evidence indicates that soluble ...
- NFIL3/E4BP4 controls type 2 T helper cell cytokine expression
[作者:Kashiwada, M; Cassel, SL; Colgan, JD; Rothman, PB,期刊:EMBO journal, 页码:2071-2082 , 文章类型: Article,,卷期:2011年30-10]
- Type 2 T helper (T(H)2) cells are critical for the development of allergic immune responses; however, the molecular mechanism controlling their effector function is still largely unclear. Here, we report that the transcr...
- LKB1 regulates TCR-mediated PLC gamma 1 activation and thymocyte positive selection
[作者:Cao, YH; Li, H; Liu, HF; Zhang, M; Hua, ZC; Ji, HB; Liu, XL,期刊:EMBO journal, 页码:2083-2093 , 文章类型: Article,,卷期:2011年30-10]
- The serine/threonine kinase LKB1 is a tumour suppressor that regulates cell growth, polarity, and proliferation in many different cell types. We previously demonstrated that LKB1 controls thymocyte survival via regulatio...
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