- Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice
[作者:Xie, ZL; Lau, K; Eby, B; Lozano, P; He, CY; Pennington, B; Li, HL; Rathi, S; Dong, YZ; Tian, R; Kem, D; Zou, MH,期刊:Diabetes, 页码:1770-1778 , 文章类型: Article,,卷期:2011年60-6]
- OBJECTIVE-Autophagy is a critical cellular system for removal of aggregated proteins and damaged organelles. Although dysregulated autophagy is implicated in the development of heart failure, the role of autophagy in the...
- Dedifferentiation of Immortalized Human Podocytes in Response to Transforming Growth Factor-beta A Model for Diabetic Podocytopathy
[作者:Herman-Edelstein, M; Thomas, MC; Thallas-Bonke, V; Saleem, M; Cooper, ME; Kantharidis, P,期刊:Diabetes, 页码:1779-1788 , 文章类型: Article,,卷期:2011年60-6]
- OBJECTIVE-Diabetic nephropathy is associated with dedifferentiation of podocytes, losing the specialized features required for efficient glomerular function and acquiring a number of profibrotic, proinflammatory, and pro...
- Decreased Cerebrovascular Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in the Diabetic Brain
[作者:Navaratna, D; Guo, SZ; Hayakawa, K; Wang, XY; Gerhardinger, C; Lo, EH,期刊:Diabetes, 页码:1789-1796 , 文章类型: Article,,卷期:2011年60-6]
- OBJECTIVE-Diabetes is an independent risk fact or for stroke. However, the underlying mechanism of how diabetes confers that this risk is not fully understood. We hypothesize that secretion of neurotrophic factors by the...
- Diazoxide-Unresponsive Congenital Hyperinsulinism in Children With Dominant Mutations of the beta-Cell Sulfonylurea Receptor SUR1
[作者:MacMullen, CM; Zhou, Q; Snider, KE; Tewson, PH; Becker, SA; Aziz, AR; Ganguly, A; Shyng, SL; Stanley, CA,期刊:Diabetes, 页码:1797-1804 , 文章类型: Article,,卷期:2011年60-6]
- OBJECTIVE-Congenital hyperinsulinemic hypoglycemia is a group of genetic disorders of insulin secretion most commonly associated with inactivating mutations of the beta-cell ATP-sensitive K+ channel (K-ATP channel) genes...
- Association of Genetic Loci With Glucose Levels in Childhood and Adolescence A Meta-Analysis of Over 6,000 Children
[作者:Barker, A; Sharp, SJ; Timpson, NJ; Bouatia-Naji, N; Warrington, NM; Kanoni, S; Beilin, LJ; Brage, S; Deloukas, P; Evans, DM; Grontved, A; Hassanali, N; Lawlor, DA; Lecoeur, C; Loos, RJF; Lye, SJ; McCarthy, MI; Mori, TA; Ndiaye, NC; Newnham, JP; Ntalla, I; Pennell, CE; St Pourcain, B; Prokopenko, I; Ring, SM; Sattar, N; Visvikis-Siest, S; Dedoussis, GV; Pahner, LJ; Froguel, P; Smith, GD; Ekelund, U; Wareham, NJ; Langenberg, C,期刊:Diabetes, 页码:1805-1812 , 文章类型: Article,,卷期:2011年60-6]
- OBJECTIVE-To investigate whether associations of common genetic variants recently identified for fasting glucose or insulin levels in nondiabetic adults are detectable in healthy children and adolescents. RESEARCH DESIGN...
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