The lithium aldol reaction of alpha-chloroaldehydes provides 1,2-anti-configured beta-ketochlorohydrins. The scope of this reaction is demonstrated as well as its application to the synthesis of the C4-C15 segment of hat...
The organocatalytic enantioselective synthesis of verbalactone and (R)-massoialactone is described. The requisite stereogenic centers of the target molecules were constructed using L-proline-catalyzed alpha-aminoxylation...
The Morita-Baylis-Hillman (MBH) reaction of aryl vinyl ketones has been achieved for the first time through cooperative catalysis of proline and brucine N-oxide. A unique mode of activation of the aldehydes through proli...
A binaphthyl sulfonimide organocatalyst was used to promote highly enantioselective and diastereoselective Michael addition reactions of ketones to nitroalkenes in water. In most cases, the products were obtained in good...
Kinetic resolution of racemic secondary alcohols by oxidative esterification using carbene catalysis is described. Good to moderate selectivity has been achieved. N-Heterocyclic carbenes (NHCs) were systematically varied...
An organocatalytic tandem Michael-Michael reaction is developed for the simple preparation of stereo complex, polycyclic compounds from simple reactants in satisfactory yields (up to 90%) and excellent diastereoselectivi...
A novel and easily accessible metal-free catalytic system, an in situ generated BINOL-phosphate-derived silicon Lewis acid, has been described for the [3+2] cycloaddition of N-benzoyl-hydrazone to cyclopentadiene to affo...
A novel strategy for the asymmetric Michael addition of aldehydes to nitroolefins with a catalytic system of organocatalyst 1 in combination with ionic-liquid-supported (ILS) benzoic acid in water has been developed. The...
An NHC-catalyzed annulation reaction of 3-halopropenals with nitrosobenzene derivatives, providing access to 2,3-disubstituted isoxazol-5(2H)-ones under mild conditions is described. This procedure represents a metal-fre...
Phosphine-promoted [3+2] cyclizations of allenic esters or phosphonates with coumarin derivatives were used to synthesize functionalized bicyclo[4.3.0]chroman-2-ones. Analogous bicyclo[4.3.0]quinolinones were similarly p...