- The Nitric Oxide Prodrug JS-K Is Effective against Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo: Involvement of Reactive Oxygen Species
[作者:Maciag, AE; Chakrapani, H; Saavedra, JE; Morris, NL; Holland, RJ; Kosak, KM; Shami, PJ; Anderson, LM; Keefer, LK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:313-320 , 文章类型: Article,,卷期:2011年336-2]
- Non-small-cell lung cancer is among the most common and deadly forms of human malignancies. Early detection is unusual, and there are no curative therapies in most cases. Diazeniumdiolate- based nitric oxide (NO)-releasi...
- Pharmacological Characterization of Diethyl-2-({3-dimethylcarbamoyl-4-[(4 '-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein
[作者:Mera, Y; Odani, N; Kawai, T; Hata, T; Suzuki, M; Hagiwara, A; Katsushima, T; Kakutani, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:321-327 , 文章类型: Article,,卷期:2011年336-2]
- Inhibitors of microsomal triglyceride transfer protein (MTP) expressed in the liver and small intestine are potential candidates for lipid-lowering agents. However, inhibition of hepatic MTP could lead to significant saf...
- Characterization of 2-[[4-Fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a Novel Positive Allosteric Modulator of the alpha(7) Nicotinic Acetylcholine Receptor
[作者:Dinklo, T; Shaban, H; Thuring, JW; Lavreysen, H; Stevens, KE; Zheng, LJ; Mackie, C; Grantham, C; Vandenberk, I; Meulders, G; Peeters, L; Verachtert, H; De Prins, E; Lesage, ASJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:560-574 , 文章类型: Article,,卷期:2011年336-2]
- The alpha(7) nicotinic acetylcholine receptor (nAChR) is a potential therapeutic target for the treatment of cognitive deficits associated with schizophrenia, Alzheimer's disease, Parkinson's disease, and attention-defic...
- N-Substituted Benztropine Analogs: Selective Dopamine Transporter Ligands with a Fast Onset of Action and Minimal Cocaine-Like Behavioral Effects
[作者:Li, SM; Kopajtic, TA; O'Callaghan, MJ; Agoston, GE; Cao, JJ; Newman, AH; Katz, JL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:575-585 , 文章类型: Article,,卷期:2011年336-2]
- Previous studies suggested that differences between the behavioral effects of cocaine and analogs of benztropine were related to the relatively slow onset of action of the latter compounds. Several N-substituted benztrop...
- Magnetic Resonance Imaging Detection and Time Course of Cerebral Microhemorrhages during Passive Immunotherapy in Living Amyloid Precursor Protein Transgenic Mice (vol 335, pg 580, 2010)
[作者:Luo, F; Rustay, NR; Seifert, T; Roesner, B; Hradil, V; Hillen, H; Ebert, U; Severin, JM; Cox, BF; Llano, DA; Day, M; Fox, GB,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:586-586 , 文章类型: Correction,,卷期:2011年336-2]
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- Regulation of Spinal Dynorphin 1-17 Release by Endogenous Pituitary Adenylyl Cyclase-Activating Polypeptide in the Male Rat: Relevance of Excitation via Disinhibition
[作者:Liu, NJ; Schnell, SA; Schulz, S; Wessendorf, MW; Gintzler, AR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:328-335 , 文章类型: Article,,卷期:2011年336-2]
- Opioids inhibit release of primary afferent transmitters but it is unclear whether the converse occurs. To test the hypothesis that primary afferent transmitters influence opioid-ergic tone, we studied the functional and...
- Reducing Undesirable Hepatic Clearance of a Tumor-Targeted Vinca Alkaloid via Novel Saccharopeptidic Modifications
[作者:Leamon, CP; Reddy, JA; Klein, PJ; Vlahov, IR; Dorton, R; Bloomfield, A; Nelson, M; Westrick, E; Parker, N; Bruna, K; Vetzel, M; Gehrke, M; Nicoson, JS; Messmann, RA; LoRusso, PM; Sausville, EA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:336-343 , 文章类型: Article,,卷期:2011年336-2]
- During a phase I trial of EC145 (a folate-targeted vinca alkaloid conjugate), constipation was identified as the dose-limiting toxicity, probably from a nonfolate receptor-related liver clearance process capable of relea...
- Cytochrome P450 2J2 Is Highly Expressed in Hematologic Malignant Diseases and Promotes Tumor Cell Growth
[作者:Chen, C; Wei, X; Rao, XQ; Wu, J; Yang, SL; Chen, FQ; Ma, D; Zhou, JF; Dackor, RT; Zeldin, DC; Wang, DW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:344-355 , 文章类型: Article,,卷期:2011年336-2]
- Cytochrome P450 2J2 (CYP2J2) epoxygenase converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs) that exert multiple biological effects in the cardiovascular system and in various human solid can...
- Antiobesity Effect of MK-5046, a Novel Bombesin Receptor Subtype-3 Agonist
[作者:Guan, XM; Metzger, JM; Yang, LM; Raustad, KA; Wang, SP; Spann, SK; Kosinski, JA; Yu, H; Shearman, LP; Faidley, TD; Palyha, O; Kan, YQ; Kelly, TM; Sebhat, I; Lin, LS; Dragovic, J; Lyons, KA; Craw, S; Nargund, RP; Marsh, DJ; Strack, AM; Reitman, ML,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:356-364 , 文章类型: Article,,卷期:2011年336-2]
- Bombesin receptor subtype-3 (BRS-3) is an orphan G protein-coupled receptor implicated in the regulation of energy homeostasis. Here, we report the biologic effects of a highly optimized BRS-3 agonist, (2S)-1,1,1-trifluo...
- Selective Binding of Bladder Muscarinic Receptors in Relation to the Pharmacokinetics of a Novel Antimuscarinic Agent, Imidafenacin, to Treat Overactive Bladder
[作者:Yamada, S; Seki, M; Ogoda, M; Fukata, A; Nakamura, M; Ito, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:365-371 , 文章类型: Article,,卷期:2011年336-2]
- The binding of orally administered imidafenacin, used to treat overactive bladders, to muscarinic receptors in rat tissue was characterized based on pharmacokinetics. The binding in six tissues including bladder tissue w...
- Pressor Effect of Apelin-13 in the Rostral Ventrolateral Medulla: Role of NAD(P)H Oxidase-Derived Superoxide
[作者:Yao, FR; Modgil, A; Zhang, Q; Pingili, A; Singh, N; O'Rourke, ST; Sun, CW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:372-380 , 文章类型: Article,,卷期:2011年336-2]
- Microinjection of apelin-13 into the rostral ventrolateral medulla (RVLM) in the brainstem increases blood pressure in rats. In the present study, we tested the hypotheses that apelin-13 directly stimulates neuronal acti...
- Successful Treatment of Acute Lung Injury with Pitavastatin in Septic Mice: Potential Role of Glucocorticoid Receptor Expression in Alveolar Macrophages
[作者:Takano, K; Yamamoto, S; Tomita, K; Takashina, M; Yokoo, H; Matsuda, N; Takano, Y; Hattori, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:381-390 , 文章类型: Article,,卷期:2011年336-2]
- There is growing evidence that the HMG-CoA reductase inhibitors (statins) provide some of the beneficial effects that are independent of their lipid-lowering effects. Recent animal experiments and clinical trials suggest...
- Prostaglandin E-2 Differentially Modulates Human Platelet Function through the Prostanoid EP2 and EP3 Receptors
[作者:Petrucci, G; De Cristofaro, R; Rutella, S; Ranelletti, FO; Pocaterra, D; Lancellotti, S; Habib, A; Patrono, C; Rocca, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:391-402 , 文章类型: Article,,卷期:2011年336-2]
- Activated human platelets synthesize prostaglandin (PG) E-2, although at lower rate than thromboxane A(2). PGE(2) acts through different receptors (EP1-4), but its role in human platelet function remains poorly character...
- Three-Dimensional Quantitative Structure-Activity Relationship Studies on UGT1A9-Mediated 3-O-Glucuronidation of Natural Flavonols Using a Pharmacophore-Based Comparative Molecular Field Analysis Model
[作者:Wu, BJ; Morrow, JK; Singh, R; Zhang, SX; Hu, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:403-413 , 文章类型: Article,,卷期:2011年336-2]
- Glucuronidation is often recognized as one of the rate-determining factors that limit the bioavailability of flavonols. Hence, design and synthesis of more bioavailable flavonols would benefit from the establishment of p...
- The Fate and Function of Therapeutic Antiaddiction Monoclonal Antibodies across the Reproductive Cycle of Rats
[作者:Hubbard, JJ; Laurenzana, EM; Williams, DK; Gentry, WB; Owens, SM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:414-422 , 文章类型: Article,,卷期:2011年336-2]
- During preclinical development of neuroprotective antiaddiction therapeutic monoclonal antibodies (mAbs) against phencyclidine (PCP) and (+)-methamphetamine, we discovered novel, gestation stage-specific changes in mAb d...
- Fatty Acid Amide Hydrolase (FAAH) Inhibition Reduces L-3,4-Dihydroxyphenylalanine-Induced Hyperactivity in the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Lesioned Non-Human Primate Model of Parkinson's Disease
[作者:Johnston, TH; Huot, P; Fox, SH; Wakefield, JD; Sykes, KA; Bartolini, WP; Milne, GT; Pearson, JP; Brotchie, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:423-430 , 文章类型: Article,,卷期:2011年336-2]
- Dopaminergic therapies remain the most efficacious symptomatic treatments for Parkinson's disease (PD) but are associated with motor complications, including dyskinesia, and nonmotor complications, such as psychosis, imp...
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