- A Substituted Anilino Enaminone Acts as a Novel Positive Allosteric Modulator of GABA(A) Receptors in the Mouse Brain
[作者:Wang, ZJ; Sun, LQ; Jackson, PL; Scott, KR; Heinbockel, T,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:916-924 , 文章类型: Article,,卷期:2011年336-3]
- A small library of anilino enaminones was analyzed for potential anticonvulsant agents. We examined the effects of three anilino enaminones on neuronal activity of output neurons, mitral cells (MC), in an olfactory bulb ...
- How Organic Anions Accumulate in Hepatocytes Lacking Mrp2: Evidence in Rat Liver
[作者:Millet, P; Moulin, M; Stieger, B; Daali, Y; Pastor, CM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:624-632 , 文章类型: Article,,卷期:2011年336-3]
- In the liver, the accumulation of hepatobiliary contrast agents is a crucial issue to understand the images of liver scintigraphy or magnetic resonance (MR) imaging. Thus, depending on the regulation of uptake and exit m...
- Silencing Mitogen-Activated Protein Kinase-Activated Protein Kinase-2 Arrests Inflammatory Bone Loss
[作者:Li, QY; Yu, H; Zinna, R; Martin, K; Herbert, B; Liu, AG; Rossa, C; Kirkwood, KL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:633-642 , 文章类型: Article,,卷期:2011年336-3]
- p38 mitogen-activated protein kinases (MAPKs) are critical for innate immune signaling and subsequent cytokine expression in periodontal inflammation and bone destruction. In fact, previous studies show that systemic p38...
- Diosgenin Modulates Vascular Smooth Muscle Cell Function by Regulating Cell Viability, Migration, and Calcium Homeostasis
[作者:Esfandiarei, M; Lam, JTN; Yazdi, SA; Kariminia, A; Dorado, JN; Kuzeljevic, B; Syyong, HT; Hu, KJ; van Breemen, C,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:925-939 , 文章类型: Article,,卷期:2011年336-3]
- In this study, we compared the potencies of diosgenin, a plant-derived sapogenin structurally similar to estrogen and progesterone, on vascular smooth muscle functions ranging from contraction and migration to apoptosis....
- meso-Transdiene Analogs Inhibit Vesicular Monoamine Transporter-2 Function and Methamphetamine-Evoked Dopamine Release
[作者:Horton, DB; Siripurapu, KB; Norrholm, SD; Culver, JP; Hojahmat, M; Beckmann, JS; Harrod, SB; Deaciuc, AG; Bardo, MT; Crooks, PA; Dwoskin, LP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:940-951 , 文章类型: Article,,卷期:2011年336-3]
- Lobeline, a nicotinic receptor antagonist and neurotransmitter transporter inhibitor, is a candidate pharmacotherapy for methamphetamine abuse. meso-Transdiene (MTD), a lobeline analog, lacks nicotinic receptor affinity,...
- Protease-Activated Receptor-1 Antagonist F 16618 Reduces Arterial Restenosis by Down-Regulation of Tumor Necrosis Factor alpha and Matrix Metalloproteinase 7 Expression, Migration, and Proliferation of Vascular Smooth Muscle Cells
[作者:Chieng-Yane, P; Bocquet, A; Letienne, R; Bourbon, T; Sablayrolles, S; Perez, M; Hatem, SN; Lompre, AM; Le Grand, B; David-Dufilho, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:643-651 , 文章类型: Article,,卷期:2011年336-3]
- Wound healing after angioplasty or stenting is associated with increased production of thrombin and the activation of protease-activated receptor 1 (PAR1). The aim of the present study was to examine the effects of a new...
- ELR510444, A Novel Microtubule Disruptor with Multiple Mechanisms of Action
[作者:Risinger, AL; Westbrook, CD; Encinas, A; Mulbaier, M; Schultes, CM; Wawro, S; Lewis, JD; Janssen, B; Giles, FJ; Mooberry, SL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:652-660 , 文章类型: Article,,卷期:2011年336-3]
- Although several microtubule-targeting drugs are in clinical use, there remains a need to identify novel agents that can overcome the limitations of current therapies, including acquired and innate drug resistance and un...
- The First Universal Opioid Ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): Characterization of the In Vitro Profile and In Vivo Behavioral Effects in Mouse Models of Acute Pain and Cocaine-Induced Reward
[作者:Khroyan, TV; Polgar, WE; Cami-Kobeci, G; Husbands, SM; Zaveri, NT; Toll, L,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:952-961 , 文章类型: Article,,卷期:2011年336-3]
- Certain behavioral features of buprenorphine, including a bell-shaped curve for antinociception and attenuation of alcohol consumption, are thought to be mediated by activation of nociceptin/orphanin FQ peptide (NOP) rec...
- In Vitro and In Vivo Evidence for Anti-Inflammatory Properties of 2-Methoxyestradiol
[作者:Shand, FHW; Langenbach, SY; Keenan, CR; Ma, SP; Wheaton, BJ; Schuliga, MJ; Ziogas, J; Stewart, AG,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:962-972 , 文章类型: Article,,卷期:2011年336-3]
- 2-Methoxyestradiol (2MEO) is an endogenous metabolite of 17 beta-estradiol that interacts with estrogen receptors and micro-tubules. It has acute anti-inflammatory activity in animal models that is not attributable to kn...
- A Toll-Like Receptor-4-Interacting Surfactant Protein-A-Derived Peptide Suppresses Tumor Necrosis Factor-alpha Release from Mouse JAWS II Dendritic Cells
[作者:Awasthi, S; Brown, K; King, C; Awasthi, V; Bondugula, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:672-681 , 文章类型: Article,,卷期:2011年336-3]
- Surfactant protein-A (SP-A) and Toll-like receptor-4 (TLR4) proteins are recognized as pathogen-recognition receptors. An exaggerated activation of TLR4 induces inflammatory response, whereas SP-A protein down-regulates ...
- The Mitochondria-Targeted Antioxidant Mitoquinone Protects against Cold Storage Injury of Renal Tubular Cells and Rat Kidneys
[作者:Mitchell, T; Rotaru, D; Saba, H; Smith, RAJ; Murphy, MP; MacMillan-Crow, LA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:682-692 , 文章类型: Article,,卷期:2011年336-3]
- The majority of kidneys used for transplantation are obtained from deceased donors. These kidneys must undergo cold preservation/storage before transplantation to preserve tissue quality and allow time for recipient sele...
- Pharmacokinetic and Pharmacodynamic Characterization of an Oral Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist
[作者:Swaney, JS; Chapman, C; Correa, LD; Stebbins, KJ; Broadhead, AR; Bain, G; Santini, AM; Darlington, J; King, CD; Baccei, CS; Lee, C; Parr, TA; Roppe, JR; Seiders, TJ; Ziff, J; Prasit, P; Hutchinson, JH; Evans, JF; Lorrain, DS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:693-700 , 文章类型: Article,,卷期:2011年336-3]
- Lysophosphatidic acid (LPA) is a bioactive phospholipid that signals through a family of at least six G protein-coupled receptors designated LPA(1-6). LPA type 1 receptor (LPA(1)) exhibits widespread tissue distribution ...
- Endothelium-Dependent Vasodilation in Human Mesenteric Artery Is Primarily Mediated by Myoendothelial Gap Junctions Intermediate Conductance Calcium-Activated K+ Channel and Nitric Oxide
[作者:Chadha, PS; Liu, L; Rikard-Bell, M; Senadheera, S; Howitt, L; Bertrand, RL; Grayson, TH; Murphy, TV; Sandow, SL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:701-708 , 文章类型: Article,,卷期:2011年336-3]
- Myoendothelial microdomain signaling via localized calcium-activated potassium channel (K-Ca) and gap junction connexins (Cx) is critical for endothelium-dependent vasodilation in rat mesenteric artery. The present study...
- Awake Rat Pharmacological Magnetic Resonance Imaging as a Translational Pharmacodynamic Biomarker: Metabotropic Glutamate 2/3 Agonist Modulation of Ketamine-Induced Blood Oxygenation Level Dependence Signals
[作者:Chin, CL; Upadhyay, J; Marek, GJ; Baker, SJ; Zhang, M; Mezler, M; Fox, GB; Day, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:709-715 , 文章类型: Article,,卷期:2011年336-3]
- Neuroimaging techniques have been exploited to characterize the effect of N-methyl-D-aspartate (NMDA) receptor antagonists on brain activation in humans and animals. However, most preclinical imaging studies were conduct...
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