- Domino approach to 2-aroyltrimethoxyindoles as novel heterocyclic combretastatin A4 analogues
[作者:Arthuis, M; Pontikis, R; Chabot, GG; Quentin, L; Scherman, D; Florent, JC,期刊:European Journal of Medicinal Chemistry, 页码:95-100 , 文章类型: Article,,卷期:2011年46-1]
- Two series of 2-aroyltrimethoxyindoles were designed to investigate the effects of the replacement of the trimethoxyphenyl ring of phenstatin with a trimethoxyindole moiety. These compounds were efficiently prepared thro...
- Novel isatinyl thiosemicarbazones derivatives as potential molecule to combat HIV-TB co-infection
[作者:Banerjee, D; Yogeeswari, P; Bhat, P; Thomas, A; Srividya, M; Sriram, D,期刊:European Journal of Medicinal Chemistry, 页码:106-121 , 文章类型: Article,,卷期:2011年46-1]
- A series of novel 5-substituted-1-(arylmethyl/alkylmethyl)-1H-indole-2,3-dione-3-(N-hydroxy/methoxy thiosemicarbazone) analogues were synthesized and evaluated for their anti-HIV activity and anti-tubercular activity in ...
- Synthesis, characterization and cytotoxicity studies of methoxy alkyl substituted metallocenes
[作者:Napoli, M; Saturnino, C; Sirignano, E; Popolo, A; Pinto, A; Longo, P,期刊:European Journal of Medicinal Chemistry, 页码:122-128 , 文章类型: Article,,卷期:2011年46-1]
- Five titanocene derivatives and one zirconium analogous, having cyclopentadienylethenylmethoxy ligand, were synthesized and fully characterized by NMR, FT-IR, and elemental analysis. Two of these complexes showed a good ...
- Isoxazolidinyl polycyclic aromatic hydrocarbons as DNA-intercalating antitumor agents
[作者:Rescifina, A; Chiacchio, U; Corsaro, A; Piperno, A; Romeo, R,期刊:European Journal of Medicinal Chemistry, 页码:129-136 , 文章类型: Article,,卷期:2011年46-1]
- The second generation and an isosteric series of isoxazolidinyl polycyclic aromatic hydrocarbons, as DNA-intercalator agents designed to act on remotely implanted tumors, have been synthesized in good yields according to...
- Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives
[作者:Al-Said, MS; Bashandy, MS; Al-Qasoumi, SI; Ghorab, MM,期刊:European Journal of Medicinal Chemistry, 页码:137-141 , 文章类型: Article,,卷期:2011年46-1]
- A variety of novel 1,2-dihydropyridines 10-17, thiophenes 18-21 and thiazole 22 having a biologically active sulfone moiety were obtained via the reaction of 2-cyano-N'-[1-(4-(piperidin-1-ylsulfonyl) phenyl) ethylidene] ...
- Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity. part 3
[作者:Herold, F; Chodkowski, A; Izbicki, L; Turlo, J; Dawidowski, M; Kleps, J; Nowak, G; Stachowicz, K; Dybala, M; Siwek, A; Mazurek, AP; Mazurek, A; Plucinski, F,期刊:European Journal of Medicinal Chemistry, 页码:142-149 , 文章类型: Article,,卷期:2011年46-1]
- A number of 4-aryl-5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine with 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole or 2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole residues were synthesized for further investigatio...
- Co(III), Ni(II), Zn(II) and Cd(II) complexes with 2-acetyl-2-thiazoline thiosemicarbazone: Synthesis, characterization, X-ray structures and antibacterial activity
[作者:Vinuelas-Zahinos, E; Luna-Giles, F; Torres-Garcia, P; Fernandez-Calderon, MC,期刊:European Journal of Medicinal Chemistry, 页码:150-159 , 文章类型: Article,,卷期:2011年46-1]
- The new ligand 2-acetyl-2-thiazoline thiosemicarbazone (HATtsc) and the complexes [Co(ATtsc)(2)](2)[CoCl4]center dot 2H(2)O (1), [Co(ATtsc)(2)]NO3 center dot H2O (2), [Ni(HATtsc)(2)](NO3)(2) (3), [ZnCl2(HATtsc)]center do...
- Synthesis and crystal structure of two new dinuclear cobalt(II) complexes interaction with HeLa cells
[作者:Gao, EJ; Gao, XN; Guan, F; Zhu, MC; Liu, L; Zhang, M; Zhang, YX; Wang, Y; Wen, Z; Zhang, Y; Zhang, Y; Hang, Q,期刊:European Journal of Medicinal Chemistry, 页码:160-167 , 文章类型: Article,,卷期:2011年46-1]
- Two novel dinuclear complexes [Co-2(L)(2)(Phen)(2)center dot 2H(2)O](n) (1). [CO2(L)(2)(bipy)(2)](n) (2) (where phen = 1,10-phenanthroline, bipy = 2,2'-bipyridine, and L = biphenyl-2,4'-dicarboxylic acid) have been synth...
- Synthesis of substituted 3-amino-N-phenyl-1H-indazole-1-carboxamides endowed with antiproliferative activity
[作者:Maggio, B; Raimondi, MV; Raffa, D; Plescia, F; Cascioferro, S; Plescia, S; Tolomeo, M; Di Cristina, A; Pipitone, RM; Grimaudo, S; Daidone, G,期刊:European Journal of Medicinal Chemistry, 页码:168-174 , 文章类型: Article,,卷期:2011年46-1]
- Several new N-phenyl-1H-indazole-1-carboxamides 1c-h and 4l,m were prepared by reacting phenyl isocyanate derivatives 3a,b with 3-amino-1H-indazole derivatives 2c,e,g or 1H-indazole 21 respectively. Chemical transformati...
- Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma
[作者:Ayyad, SEN; Makki, MS; Al-Kayal, NS; Basaif, SA; El-Foty, KO; Asiri, AM; Alarif, WM; Badria, FA,期刊:European Journal of Medicinal Chemistry, 页码:175-182 , 文章类型: Article,,卷期:2011年46-1]
- Three new diterpenes Amijiol acetate (3), dolabellane, Dolabellatrienol (4), and dolastane, 10-diacetate (9) were isolated together with the previously described Pachydictyol A (1), Isopachydictyol A (2), 8 beta-hydroxyp...
- Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors
[作者:Kulig, K; Wieckowski, K; Wieckowska, A; Gajda, J; Pochwat, B; Hofner, GC; Wanner, KT; Malawska, B,期刊:European Journal of Medicinal Chemistry, 页码:183-190 , 文章类型: Article,,卷期:2011年46-1]
- This study presents the synthesis of novel substituted 4-hydroxybutanamides and their influence on the activity of murine GABA transport proteins GAT1-GAT4. The active compounds, derivatives of N-aryl-alkyl-2-(4-diphenyl...
- Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities
[作者:Pontiki, E; Hadjipavlou-Litina, D; Litinas, K; Nicolotti, O; Carotti, A,期刊:European Journal of Medicinal Chemistry, 页码:191-200 , 文章类型: Article,,卷期:2011年46-1]
- A series of novel acrylic acid derivatives bearing at the 3 position thienyl, furfuryl and 3,5-ditert-butyl-4-hydroxyphenyl substituents have been designed, synthesized and tested as potential dual lipoxygenase/cyclooxyg...
- Synthesis and antibacterial activity of novel ketolides with 11,12-sulfur contained aryl alkyl side chains
[作者:Chen, XZ; Xu, P; Liu, L; Zheng, D; Lei, PS,期刊:European Journal of Medicinal Chemistry, 页码:208-217 , 文章类型: Article,,卷期:2011年46-1]
- A novel series of ketolides with 11,12-sulfur contained aryl alkyl side chains were synthesized and evaluated for their antibacterial activity. These ketolides exhibited potent activity against key macrolide sensitive an...
- Prediction of drug intestinal absorption by new linear and non-linear QSPR
[作者:Talevi, A; Goodarzi, M; Ortiz, EV; Duchowicz, PR; Bellera, CL; Pesce, G; Castro, EA; Bruno-Blanch, LE,期刊:European Journal of Medicinal Chemistry, 页码:218-228 , 文章类型: Article,,卷期:2011年46-1]
- In order to minimize the high attrition rate that usually characterizes drug research and development projects, current medicinal chemists aim to characterize both pharmacological and ADME profiles at the beginning of dr...
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