- Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support
[作者:Gupta, M; Paul, S; Gupta, R,期刊:European Journal of Medicinal Chemistry, 页码:631-635 , 文章类型: Article,,卷期:2011年46-2]
- A simple, efficient and environment-friendly procedure is developed for the synthesis of 1-substitued-8-aryl-3-alkyliary1-4H-pyrazolo[4,54][1,2,4]triazolo[4,3-b][1,2,4]triazepines in the presence of N,N-dimethylformamide...
- 3-Benzylamino-beta-carboline derivatives induce apoptosis through G(2)/M arrest in human carcinoma cells He La S-3
[作者:Ikeda, R; Iwaki, T; Iida, T; Okabayashi, T; Nishi, E; Kurosawa, M; Sakai, N; Konakahara, T,期刊:European Journal of Medicinal Chemistry, 页码:636-646 , 文章类型: Article,,卷期:2011年46-2]
- beta-Carboline derivatives are known as the lead compounds for anti-tumor agents. To examine an optimal structure for anti-tumor activity, we synthesized a variety of beta-carboline derivatives, possessing a variety of s...
- Molecular modeling study and synthesis of quinazolinone-arylpiperazine derivatives as alpha(1)-adrenoreceptor antagonists
[作者:Abou-Seri, SM; Abouzid, K; Abou El Ella, DA,期刊:European Journal of Medicinal Chemistry, 页码:647-658 , 文章类型: Article,,卷期:2011年46-2]
- Three series of new 2-[(4-substituted piperazin-1-yl) methyliquinazolin-4(3H)-ones 4a-c, Ethyl 6,7-dimethoxy-4-oxo-3-[2-(4-substituted piperazin-1-yl)acetamido/propanamido]-3,4-dihydroquinazoline-2-carboxylates 9a-f and ...
- Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives
[作者:Kumar, S; Bawa, S; Drabu, S; Gupta, H; Machwal, L; Kumar, R,期刊:European Journal of Medicinal Chemistry, 页码:670-675 , 文章类型: Article,,卷期:2011年46-2]
- A new series of N-[(2-chloro-8-methylquinolin-3-yl)methyl]-(substituted)-aniline/butylamine/cyclohexylamine/benzylamine derivatives (4a-p) was synthesized by nucleophilic substitution reaction of 2-chloro-3-(chloromethyl...
- 4-Anilinoquinoline triazines: A novel class of hybrid antimalarial agents
[作者:Kumar, A; Srivastava, K; Kumar, SR; Siddiqi, MI; Puri, SK; Sexana, JK; Chauhan, PMS,期刊:European Journal of Medicinal Chemistry, 页码:676-690 , 文章类型: Article,,卷期:2011年46-2]
- A novel class of hybrid 4-anilinoquinoline triazines have been synthesized and evaluated in vitro for their antimalarial activity against CQ-sensitive 3D7 strain of P. falciparum as well as for their cytotoxicity toward ...
- Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2, 3-dihydroquinazolinone hybrids as anticancer agents
[作者:Kamal, A; Bharathi, EV; Reddy, JS; Ramaiah, MJ; Dastagiri, D; Reddy, MK; Viswanath, A; Reddy, TL; Shaik, TB; Pushpavalli, SNCVL; Bhadra, MP,期刊:European Journal of Medicinal Chemistry, 页码:691-703 , 文章类型: Article,,卷期:2011年46-2]
- A series of new 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydro quinazolinone hybrids with different linker architectures have been designed and synthesized. These compounds have been evaluated for their anticancer a...
- Syntheses, antiproliferative activity and theoretical characterization of acitretin-type retinoids with changes in the lipophilic part
[作者:Magoulas, GE; Bariamis, SE; Athanassopoulos, CM; Haskopoulos, A; Dedes, PG; Krokidis, MG; Karamanos, NK; Kletsas, D; Papaioannou, D; Maroulis, G,期刊:European Journal of Medicinal Chemistry, 页码:721-737 , 文章类型: Article,,卷期:2011年46-2]
- Acitretin analogs, incorporating changes in the lipophilic part, were efficiently synthesized from commercially available aromatic aldehydes or methyl ketones using the Wittig or Horner-Wadsworth-Emmons reaction. Their a...
- Synthesis and structure-activity relationship of 2-thiopyrimidine-4-one analogs as antimicrobial and anticancer agents
[作者:Prachayasittikul, S; Worachartcheewan, A; Nantasenamat, C; Chinworrungsee, M; Sornsongkhram, N; Ruchirawat, S; Prachayasittikul, V,期刊:European Journal of Medicinal Chemistry, 页码:738-742 , 文章类型: Article,,卷期:2011年46-2]
- Considering that some thiopyrimidines were previously reported as potential therapeutics, the present study achieved novel analogs of bioactive 2-substituted thiopyrimidines-4-(3H)-ones via base catalyzed alkylation reac...
- Synthesis, DNA/RNA affinity and antitumour activity of new aromatic diamidines linked by 3,4-ethylenedioxythiophene
[作者:Stolic, I; Miskovic, K; Piantanida, I; Loncar, MB; Glavas-Obrovac, L; Bajic, M,期刊:European Journal of Medicinal Chemistry, 页码:743-755 , 文章类型: Article,,卷期:2011年46-2]
- A series of novel 2,5-bis(amidinophenyl)-3,4-ethylenedioxythiophenes (5-10 and 15) has been synthesized. Compounds 5-10 bind to the DNA minor groove as the dominant binding site and strongly stabilize the double helix of...
- HIV-1 integrase strand-transfer inhibitors: Design, synthesis and molecular modeling investigation
[作者:De Luca, L; De Grazia, S; Ferro, S; Gitto, R; Christ, F; Debyser, Z; Chimirri, A,期刊:European Journal of Medicinal Chemistry, 页码:756-764 , 文章类型: Article,,卷期:2011年46-2]
- This study is focused on a new series of benzylindole derivatives with various substituents at the benzene-fused ring, suggested by our 3D pharmacophore model developed for HIV-1 integrase inhibitors (INIs). All synthesi...
- Synthesis of 4H-chromene, coumarin, 12H-chromeno[2,3-d]pyrimidine derivatives and some of their antimicrobial and cytotoxicity activities
[作者:Sabry, NM; Mohamed, HM; Khattab, ESAEH; Motlaq, SS; El-Agrody, AM,期刊:European Journal of Medicinal Chemistry, 页码:765-772 , 文章类型: Article,,卷期:2011年46-2]
- Condensation of 3-N,N-diethylaminophenol (1) with alpha-cyanocinnamonitriles (2a-c) and ethyl alpha-cyanocinnamates (2d-f) provided compounds 3a-f and 4a-c. 12H-Chromeno[2,3-d]pyrimidine derivatives 6,11-13 and 16 were o...
- Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates
[作者:Menezes, JCJMDS; Kamat, SP; Cavaleiro, JAS; Gaspar, A; Garrido, J; Borges, F,期刊:European Journal of Medicinal Chemistry, 页码:773-777 , 文章类型: Article,,卷期:2011年46-2]
- Long chain alkyl hydroxycinnamates (8-21) were synthesized from the corresponding half esters of malonic acid (5-7) and benzaldehyde derivatives by Knoevenagel condensation. The total antioxidant capacity of these hydrox...
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