- Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-Amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylpheny l}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo [3,4-d]pyrimidine-6-carboxamide
[作者:ZEHNDER LUKE; BENNETT MICHAEL; MENG JERRY; HUANG BUWEN; NINKOVIC SACHA; WANG FEN; BRAGANZA JOHN; TATLOCK JOHN; JEWELL TANYA; ZHOU JOE ZHONGXIANG; BURKE BEN; WANG JEFF; MAEGLEY KAREN; MEHTA PRAMOD P; YIN MINJEAN; GAJIWALA KETAN S; HICKEY MICHAEL J; YAMAZAKI SHINJI; SMITH EVAN; KANG PING; SISTLA ANAND; DOVALSANTOS ELENA; GEHRING MICHAEL R; KANIA ROBERT; WYTHES MARTIN; KUNG PEIPEI,期刊:Journal of Medicinal Chemistry, 页码:3368-3385 , 文章类型: Article,,卷期:2011年54-9]
- A novel class of heat shock protein 90 (Hsp90) inhibitors was discovered by high-throughput screening and was subsequently optimized using a combination of structure-based design, parallel synthesis, and the application ...
- 1,6-Dihydro-2H-indeno[5,4-b]furan Derivatives: Design, Synthesis, and Pharmacological Characterization of a Novel Class of Highly Potent MT2-Selective Agonists
[作者:KOIKE TATSUKI; HOASHI YASUTAKA; TAKAI TAKAFUMI; NAKAYAMA MASAHARU; YUKUHIRO NOBUHITO; ISHIKAWA TAKASHI; HIRAI KEISUKE; UCHIKAWA OSAMU,期刊:Journal of Medicinal Chemistry, 页码:3436-3444 , 文章类型: Article,,卷期:2011年54-9]
- A novel series of 1,6-dihydro-2H-indeno[5,4-b]furan derivatives were designed and synthesized as MT2-selective ligands. This scaffold was identified as a potent mimic of the 5-methoxy indole core of melatonin, and introd...
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