- Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice
[作者:Jarvinen, TAH; Ruoslahti, E,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21671-21676 , 文章类型: Article,,卷期:2010年107-50]
- Permanent scars form upon healing of tissue injuries such as those caused by ischemia (myocardial infarction, stroke), trauma, surgery, and inflammation. Current options in reducing scar formation are limited to local in...
- Malignant cells facilitate lung metastasis by bringing their own soil
[作者:Duda, DG; Duyverman, AMMJ; Kohno, M; Snuderl, M; Steller, EJA; Fukumura, D; Jain, RK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21677-21682 , 文章类型: Article,,卷期:2010年107-50]
- Metastatic cancer cells (seeds) preferentially grow in the secondary sites with a permissive microenvironment (soil). We show that the metastatic cells can bring their own soil-stromal components including activated fibr...
- As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia
[作者:Mao, JH; Sun, XY; Liu, JX; Zhang, QY; Liu, P; Huang, QH; Li, KQK; Chen, QA; Chen, Z; Chen, SJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21683-21688 , 文章类型: Article,,卷期:2010年107-50]
- Arsenic, a curative agent for acute promyelocytic leukemia, induces cell apoptosis and degradation of BCR-ABL in chronic myelogenous leukemia (CML). We demonstrated that ubiquitination and degradation of BCR-ABL was medi...
- A regulon conserved in monocot and dicot plants defines a functional module in antifungal plant immunity
[作者:Humphry, M; Bednarek, P; Kemmerling, B; Koh, S; Stein, M; Gobel, U; Stuber, K; Pislewska-Bednarek, M; Loraine, A; Schulze-Lefert, P; Somerville, S; Panstruga, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21896-21901 , 文章类型: Article,,卷期:2010年107-50]
- At least two components that modulate plant resistance against the fungal powdery mildew disease are ancient and have been conserved since the time of the monocot-dicot split (approximate to 200 Mya). These components ar...
- An NADPH-dependent genetic switch regulates plant infection by the rice blast fungus
[作者:Wilson, RA; Gibson, RP; Quispe, CF; Littlechild, JA; Talbot, NJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21902-21907 , 文章类型: Article,,卷期:2010年107-50]
- To cause rice blast disease, the fungus Magnaporthe oryzae breaches the tough outer cuticle of the rice leaf by using specialized infection structures called appressoria. These cells allow the fungus to invade the host p...
- Repression by an auxin/indole acetic acid protein connects auxin signaling with heat shock factor-mediated seed longevity
[作者:Carranco, R; Espinosa, JM; Prieto-Dapena, P; Almoguera, C; Jordano, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21908-21913 , 文章类型: Article,,卷期:2010年107-50]
- The plant hormone auxin regulates growth and development by modulating the stability of auxin/indole acetic acid (Aux/IAA) proteins, which in turn repress auxin response factors (ARFs) transcriptional regulators. In tran...
- Source identification in two criminal cases using phylogenetic analysis of HIV-1 DNA sequences
[作者:Scaduto, DI; Brown, JM; Haaland, WC; Zwickl, DJ; Hillis, DM; Metzker, ML,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21242-21247 , 文章类型: Article,,卷期:2010年107-50]
- Phylogenetic analysis has been widely used to test the a priori hypothesis of epidemiological clustering in suspected transmission chains of HIV-1. Among studies showing strong support for relatedness between HIV samples...
- Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes
[作者:Kowanetz, M; Wu, XM; Lee, J; Tan, M; Hagenbeek, T; Qu, XP; Yu, LL; Ross, J; Korsisaari, N; Cao, T; Bou-Reslan, H; Kallop, D; Weimer, R; Ludlam, MJC; Kaminker, JS; Modrusan, Z; van Bruggen, N; Peale, FV; Carano, R; Meng, YG; Ferrara, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21248-21255 , 文章类型: Article,,卷期:2010年107-50]
- Priming of the organ-specific premetastatic sites is thought to be an important yet incompletely understood step during metastasis. In this study, we show that the metastatic tumors we examined overexpress granulocyte-co...
|