- Human Monoclonal Antibody Reactivity With Human Leukocyte Antigen Class I Epitopes Defined by Pairs of Mismatched Eplets and Self-Eplets
[作者：Marrari, M; Mostecki, J; Mulder, A; Claas, F; Balazs, I; Duquesnoy, RJ,期刊：Transplantation, 页码：1468-1472 , 文章类型： Article，,卷期：2010年90-12]
- Aim. Humoral sensitization affects transplant outcome, and it is now apparent that human leukocyte antigen (HLA) antibodies are specific for epitopes rather than antigens. Such epitopes can be structurally defined by HLA...
- Anti-Angiotensin Type 1 Receptor Antibodies Associated With Antibody Mediated Rejection in Donor HLA Antibody Negative Patients
[作者：Reinsmoen, NL; Lai, CH; Heidecke, H; Haas, M; Cao, K; Ong, G; Naim, M; Wang, Q; Mirocha, J; Kahwaji, J; Vo, AA; Jordan, SC; Dragun, D,期刊：Transplantation, 页码：1473-1477 , 文章类型： Article，,卷期：2010年90-12]
- Background. Angiotensin type 1 receptor (AT(1)R) mediates most physiologic and pathophysiologic actions of its endogenous ligand, angiotensin II, with overactivity leading to vascular remodeling and hypertension. Antibod...
- Glomerular Inflammation in Renal Allografts Biopsies After the First Year: Cell Types and Relationship With Antibody-Mediated Rejection and Graft Outcome
[作者：Papadimitriou, JC; Drachenberg, CB; Munivenkatappa, R; Ramos, E; Nogueira, J; Sailey, C; Klassen, DK; Haririan, A,期刊：Transplantation, 页码：1478-1485 , 文章类型： Article，,卷期：2010年90-12]
- Background. Antibody-mediated rejection manifests with glomerular and peritubular capillary inflammation and transplant glomerulopathy (TG). The role of glomerular inflammation (GI) components in the development of TG an...
- The Role of Proteasome Inhibition With Bortezomib in the Treatment of Antibody-Mediated Rejection After Kidney-Only or Kidney-Combined Organ Transplantation
[作者：Flechner, SM; Fatica, R; Askar, M; Stephany, BR; Poggio, E; Koo, A; Banning, S; Chiesa-Vottero, A; Srinivas, T,期刊：Transplantation, 页码：1486-1492 , 文章类型： Article，,卷期：2010年90-12]
- Background. We report our initial experience in using the proteasome inhibitor, bortezomib, to treat established antibody-mediated rejection (AMR) in 20 patients. Methods. There were 16 kidney-only and 4 kidney-combined ...
- Protective Immunity Remains Intact After Antibody Removal by Means of Proteasome Inhibition
[作者：Everly, MJ; Terasaki, PI; Hopfield, J; Trivedi, HL; Kaneku, H,期刊：Transplantation, 页码：1493-1498 , 文章类型： Article，,卷期：2010年90-12]
- Background. Proteasome inhibition abrogates donor-specific anti-human leukocyte antigen (HLA) antibody (DSA) in patients posttransplant. However, its effects on protective humoral immunity to vaccine antigens remain unkn...
- Glomerular Filtration Rate Slopes Have Significantly Improved Among Renal Transplants in the United States
[作者：Srinivas, TR; Flechner, SM; Poggio, ED; Askar, M; Goldfarb, DA; Navaneethan, SD; Schold, JD,期刊：Transplantation, 页码：1499-1505 , 文章类型： Article，,卷期：2010年90-12]
- Introduction. In recent years, the use of higher risk donor organs and steroid avoidance regimens with potential increased acute rejection risk have increased. We hypothesized that these patterns adversely affect changes...
- Mechanism Analysis of Long-Term Graft Survival by Monocarboxylate Transporter-1 Inhibition
[作者：Cho, KS; Yamada, T; Wynn, C; Behanna, HA; Hong, IC; Manaves, V; Nakanishi, T; Hirose, J; Abe, Y; Jiang, HS; Tamura, K; Saita, Y,期刊：Transplantation, 页码：1299-1306 , 文章类型： Article，,卷期：2010年90-12]
- Background. Monocarboxylate transporter (MCT)-1, a member of a family of molecules, transports monocarboxylates such as lactate. Inhibiting MCT-1 leads to long-term graft survival in rodent heart transplantation and indu...
- Is the Increase in DCD Organ Donors in the United Kingdom Contributing to a Decline in DBD Donors?
[作者：Summers, DM; Counter, C; Johnson, RJ; Murphy, PG; Neuberger, JM; Bradley, JA,期刊：Transplantation, 页码：1506-1510 , 文章类型： Article，,卷期：2010年90-12]
- Introduction. Organ donation after brain death (DBD) has declined in the United Kingdom, whereas donation after cardiac death (DCD) has increased markedly. We sought to understand the reasons for the decline in DBD and d...
- Efficacy and Safety of Thymoglobulin Induction as an Alternative Approach for Steroid-Free Maintenance Immunosuppression in Pediatric Renal Transplantation
[作者：Li, L; Chaudhuri, A; Chen, A; Zhao, XM; Bezchinsky, M; Concepcion, W; Salvatierra, O; Sarwal, MM,期刊：Transplantation, 页码：1516-1520 , 文章类型： Article，,卷期：2010年90-12]
- Background. Given the recent withdrawal of daclizumab (DAC), the safety and efficacy of thymoglobulin (TMG) was tested as an alternative induction agent for steroid-free (SF) immunosuppression in pediatric kidney transpl...
- Kidney-Derived Mesenchymal Stromal Cells Modulate Dendritic Cell Function to Suppress Alloimmune Responses and Delay Allograft Rejection
[作者：Huang, YF; Chen, P; Zhang, CB; Ko, GJ; Ruiz, M; Fiorina, P; Hussain, MA; Wasowska, BA; Rabb, H; Womer, KL,期刊：Transplantation, 页码：1307-1311 , 文章类型： Article，,卷期：2010年90-12]
- Background. Mesenchymal stromal cells (MSCs) are multipotent cells with immunoregulatory capacity that are present in most adult organs. We previously demonstrated that co-culture of C57BL/6 kidney-derived MSCs (KSCs) in...
- Regulatory T-Cell Generation and Kidney Allograft Tolerance Induced by Mesenchymal Stem Cells Associated With Indoleamine 2,3-Dioxygenase Expression
[作者：Ge, W; Jiang, JF; Arp, J; Liu, WH; Garcia, B; Wang, H,期刊：Transplantation, 页码：1312-1320 , 文章类型： Article，,卷期：2010年90-12]
- Background. The immunoregulatory properties of mesenchymal stem cells (MSCs) have been observed in vitro and in vivo. However, the underlying mechanisms of this immunomodulation remain undefined. Recent research demonstr...
- An Integrated Safety Profile Analysis of Belatacept in Kidney Transplant Recipients
[作者：Grinyo, J; Charpentier, B; Pestana, JM; Vanrenterghem, Y; Vincenti, F; Reyes-Acevedo, R; Apanovitch, AM; Gujrathi, S; Agarwal, M; Thomas, D; Larsen, CP,期刊：Transplantation, 页码：1521-1527 , 文章类型： Article，,卷期：2010年90-12]
- Background. Belatacept is associated with better renal function and an improved cardiovascular/metabolic risk profile versus cyclosporine in kidney transplant recipients. The current analysis examined pooled safety data ...
- Belatacept-Based Regimens Versus a Cyclosporine A-Based Regimen in Kidney Transplant Recipients: 2-Year Results From the BENEFIT and BENEFIT-EXT Studies
[作者：Larsen, CP; Grinyo, J; Medina-Pestana, J; Vanrenterghem, Y; Vincenti, F; Breshahan, B; Campistol, JM; Florman, S; Rial, MD; Kamar, N; Block, A; Di Russo, G; Lin, CS; Garg, P; Charpentier, B,期刊：Transplantation, 页码：1528-1535 , 文章类型： Article，,卷期：2010年90-12]
- Background. At 1 year, belatacept was associated with similar patient/graft survival, better renal function, and an improved cardiovascular/metabolic risk profile versus cyclosporine A (CsA) in the Belatacept Evaluation ...
- Ex Vivo-Expanded Human Regulatory T Cells Prevent the Rejection of Skin Allografts in a Humanized Mouse Model
[作者：Issa, F; Hester, J; Goto, R; Nadig, SN; Goodacre, TE; Wood, K,期刊：Transplantation, 页码：1321-1327 , 文章类型： Article，,卷期：2010年90-12]
- Background. Composite tissue transplantation effectively reconstructs the most complex defects, but its use is limited because of harmful immunosuppression and the high susceptibility of skin to rejection. Development of...
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