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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共48条记录   Tie1 attenuation reduces murine atherosclerosis in a dose-dependent and shear stress-specific manner [作者：Woo, KV; Qu, XH; Babaev, VR; Linton, MF; Guzman, RJ; Fazio, S; Baldwin, HS,期刊：Journal of clinical investigation, 页码：1624-1635 , 文章类型： Article，,卷期：2011年121-4] Although the response of endothelial cells to the disturbed blood flow in the vicinity of atherosclerotic lesions is known to be distinct from that elicited by nonatherogenic laminar flow, the mechanisms involved are poo... Tolerogenic pDCs: spotlight on Foxo3 [作者：Bronte, V,期刊：Journal of clinical investigation, 页码：1247-1250 , 文章类型： Editorial Material，,卷期：2011年121-4] Cancer creates a peculiar inflammatory environment enriched for transcription factors with a negative influence on adaptive immunity. In this issue of the JCI, Watkins and colleagues identify Foxo3 as a master regulator ... Myocarditis: a defect in central immune tolerance? [作者：Metzger, TC; Anderson, MS,期刊：Journal of clinical investigation, 页码：1251-1253 , 文章类型： Editorial Material，,卷期：2011年121-4] Myocarditis, or inflammation of the heart, is a potentially devastating disease that can result from both viral infection and autoimmune attack of self antigens in the heart. In the current issue of the JCI, Lv and colle... Niche competition and cancer metastasis to bone [作者：Schuettpelz, LG; Link, DC,期刊：Journal of clinical investigation, 页码：1253-1255 , 文章类型： Editorial Material，,卷期：2011年121-4] The molecular basis for the preferential metastases of certain cancers to bone is not well understood. In this issue of the JCI, Shiozawa et al. provide compelling evidence that prostate cancer cells preferentially home ... Finding a needle in a haystack: whole genome sequencing and mutation discovery in mu rifle models [作者：Rampal, RK; Levine, RL,期刊：Journal of clinical investigation, 页码：1255-1258 , 文章类型： Editorial Material，,卷期：2011年121-4] Acute promyelocytic leukemia (APL) is a malignancy of the bone marrow, in which there is a deficiency of myeloid cells and an excess of immature cells called promyelocytes. APL is most commonly caused by a translocation ... Dietary nitrate, nitric oxide, and restenosis [作者：Cooke, JP; Ghebremariam, YT,期刊：Journal of clinical investigation, 页码：1258-1260 , 文章类型： Editorial Material，,卷期：2011年121-4] Endothelium-derived NO controls the contractility and growth state of the underlying vascular smooth muscle cells and regulates the interaction of the vessel wall with circulating blood elements. Acute injury of the vess... PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice [作者：Welch, JS; Yuan, WL; Ley, TJ,期刊：Journal of clinical investigation, 页码：1636-1645 , 文章类型： Article，,卷期：2011年121-4] Acute promyelocytic leukemia (APL) is characterized by the t(15;17) translocation that generates the fusion protein promyelocytic leukemia-retinoic acid receptor a (PML-RARA) in nearly all cases. Multiple prior mouse mod... Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats [作者：Alef, MJ; Vallabhaneni, R; Carchman, E; Morris, SM; Shiva, S; Wang, YN; Kelley, EE; Tarpey, MM; Gladwin, MT; Tzeng, E; Zuckerbraun, BS,期刊：Journal of clinical investigation, 页码：1646-1656 , 文章类型： Article，,卷期：2011年121-4] Vascular disease, a significant cause of morbidity and mortality in the developed world, results from vascular injury. Following vascular injury, damaged or dysfunctional endothelial cells and activated SMCs engage in va... Neutrophils give us a shock [作者：Lowell, CA,期刊：Journal of clinical investigation, 页码：1260-1263 , 文章类型： Editorial Material，,卷期：2011年121-4] Systemic anaphylaxis is generally recognized as a severe allergic reaction caused by IgE-mediated activation of mast cells, leading to massive release of vasoactive mediators that induce acute hypotension and shock. Howe... Good COP1 or bad COP1? In vivo veritas [作者：Wei, WY; Kaelin, WG,期刊：Journal of clinical investigation, 页码：1263-1265 , 文章类型： Editorial Material，,卷期：2011年121-4] The evolutionarily conserved protein COP1 has been shown to operate as an E3 ubiquitin ligase complex, and a number of putative substrates have been identified, including the c-JUN oncoprotein and p53 tumor suppressor pr... The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice [作者：Zhou, XZ; Huang, PY; Shi, R; Lee, TH; Lu, GN; Zhang, ZH; Bronson, R; Lu, KP,期刊：Journal of clinical investigation, 页码：1266-1282 , 文章类型： Article，,卷期：2011年121-4] Telomerase is activated in most human cancers and is critical for cancer cell growth. However, little is known about the significance of telomerase activation in chromosome instability and cancer initiation. The gene enc... Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice [作者：Fu, JX; Wei, B; Wen, T; Johansson, MEV; Liu, XW; Bradford, E; Thomsson, KA; McGee, S; Mansour, L; Tong, MM; McDaniel, JM; Sferra, TJ; Turner, JR; Chen, H; Hansson, GC; Braun, J; Xia, LJ,期刊：Journal of clinical investigation, 页码：1657-1666 , 文章类型： Article，,卷期：2011年121-4] Mucin-type O-linked oligosaccharides (O-glycans) are primary components of the intestinal mucins that form the mucus gel layer overlying the gut epithelium. Impaired expression of intestinal O-glycans has been observed i... DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation (vol 120, pg 756, 2010) [作者：Koliwad, SK; Streeper, RS; Monetti, M; Cornelissen, I; Chan, LN; Terayama, K; Naylor, S; Rao, M; Hubbard, B; Farese, RV,期刊：Journal of clinical investigation, 页码：1667-1667 , 文章类型： Correction，,卷期：2011年121-4] The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice (vol 120, pg 1627, 2010) [作者：Leviel, F; Hubner, CA; Houillier, P; Morla, L; El Moghrabi, S; Brideau, G; Hassan, H; Parker, MD; Kurth, I; Kougioumtzes, A; Sinning, A; Pech, V; Riemondy, KA; Miller, RL; Hummler, E; Shull, GE; Aronson, PS; Doucet, A; Wall, SM; Chambrey, R; Eladari, D,期刊：Journal of clinical investigation, 页码：1668-1668 , 文章类型： Correction，,卷期：2011年121-4] Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells [作者：Connell, CM; Shibata, A; Tookman, LA; Archibald, KM; Flak, MB; Pirlo, KJ; Lockley, M; Wheatley, SP; McNeish, IA,期刊：Journal of clinical investigation, 页码：1283-1297 , 文章类型： Article，,卷期：2011年121-4] Oncolytic adenoviruses replicate selectively within and lyse malignant cells. As such, they are being developed as anticancer therapeutics. However, the sensitivity of ovarian cancers to adenovirus cytotoxicity varies gr... Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow [作者：Shiozawa, Y; Pedersen, EA; Havens, AM; Jung, YH; Mishra, A; Joseph, J; Kim, JK; Pate, LR; Ying, C; Ziegler, AM; Pienta, MJ; Song, JH; Wang, JC; Loberg, RD; Krebsbach, PH; Pienta, KJ; Taichman, RS,期刊：Journal of clinical investigation, 页码：1298-1312 , 文章类型： Article，,卷期：2011年121-4] HSC homing, quiescence, and self-renewal depend on the bone marrow HSC niche. A large proportion of solid tumor metastases are bone metastases, known to usurp HSC homing pathways to establish footholds in the bone marrow...