- Inhibition of signal transducer and activator of transcription 5 by the inhibitor of janus kinases stimulates dormant human leukemia CD34(+)/CD38(-) cells and sensitizes them to antileukemia agents
[作者:Ikezoe, T; Yang, J; Nishioka, C; Kojima, S; Takeuchi, A; Koeffler, HP; Yokoyama, A,期刊:International Journal of Cancer, 页码:2317-2325 , 文章类型: Article,,卷期:2011年128-10]
- To verify molecular mechanisms by which leukemia stem cells (LSCs) maintain a dormant state, we explored the activity of the major prosurvival signal pathways in CD34(+)/CD38(-) compartment, supposed to contain LSCs, and...
- Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis
[作者:Gannon, PO; Medelci, S; Le Page, C; Beaulieu, M; Provencher, DM; Mes-Masson, AM; Santos, MM,期刊:International Journal of Cancer, 页码:2326-2334 , 文章类型: Article,,卷期:2011年128-10]
- Cancer cells require large amounts of micronutrients, particularly iron, for their rapid growth and frequent divisions. Cellular iron uptake is regulated by the transferrin receptor and the hemochromatosis protein (HFE) ...
- A genetic variant in a PP2A regulatory subunit encoded by the PPP2R2B gene associates with altered breast cancer risk and recurrence
[作者:Vazquez, A; Kulkarni, D; Grochola, LF; Bond, GL; Barnard, N; Toppmeyer, D; Levine, AJ; Hirshfield, KM,期刊:International Journal of Cancer, 页码:2335-2343 , 文章类型: Article,,卷期:2011年128-10]
- A recent candidate gene association study identified a single nucleotide polymorphism (SNP) in the PPP2R2B gene (rs319217, A/G) that manifests allelic differences in the cellular responses to treatment with chemotherapeu...
- Impact of diabetes mellitus on incidence of hepatocellular carcinoma in chronic hepatitis C patients treated with interferon-based antiviral therapy
[作者:Hung, CH; Lee, CM; Wang, JH; Hu, TH; Chen, CH; Lin, CY; Lu, SN,期刊:International Journal of Cancer, 页码:2344-2352 , 文章类型: Article,,卷期:2011年128-10]
- There is strong evidence linking chronic hepatitis C virus (HCV) infection and Type 2 diabetes mellitus (DM). Recent studies have suggested that DM is associated with increased risk of developing hepatocellular carcinoma...
- Neighbor of Punc E11, a novel oncofetal marker for hepatocellular carcinoma
[作者:Marquardt, JU; Quasdorff, M; Varnholt, H; Curth, HM; Mesghenna, S; Protzer, U; Goeser, T; Nierhoff, D,期刊:International Journal of Cancer, 页码:2353-2363 , 文章类型: Article,,卷期:2011年128-10]
- Hepatocellular carcinoma (HCC) is the 5th common malignancy worldwide, but established markers fail to detect up to one third of HCC. We have recently identified Neighbor of Punc E11 (Nope) as a surface marker for murine...
- Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome
[作者:Wang, CI; Wang, CL; Wang, CW; Chen, CD; Wu, CC; Liang, Y; Tsai, YH; Chang, YS; Yu, JS; Yu, CJ,期刊:International Journal of Cancer, 页码:2364-2372 , 文章类型: Article,,卷期:2011年128-10]
- The cancer cell secretome may contain potentially useful biomarkers. In this study, we integrated the profiles of secreted proteins in lung cancer cell lines with mRNA expression levels from pulmonary adenocarcinoma tiss...
- Evaluation of prediagnostic prostate-specific antigen dynamics as predictors of death from prostate cancer in patients treated conservatively
[作者:O'Brien, MF; Cronin, AM; Fearn, PA; Savage, CJ; Smith, B; Stasi, J; Scardino, PT; Fisher, G; Cuzick, J; Moller, H; Oliver, RT; Berney, DM; Foster, CS; Eastham, JA; Vickers, AJ; Lilja, H,期刊:International Journal of Cancer, 页码:2373-2381 , 文章类型: Article,,卷期:2011年128-10]
- Prostate-specific antigen (PSA) dynamics have been proposed to predict outcome in men with prostate cancer. We assessed the value of PSA velocity (PSAV) and PSA doubling time (PSADT) for predicting prostate cancer-specif...
- Detection of melanoma-derived cancer-testis antigen CT16 in patient sera by a novel immunoassay
[作者:Rappu, P; Nylund, C; Ristiniemi, N; Kulpakko, J; Vihinen, P; Hernberg, M; Mirtti, T; Alanen, K; Kallajoki, M; Vuoristo, MS; Pyrhonen, S; Heino, J,期刊:International Journal of Cancer, 页码:2382-2392 , 文章类型: Article,,卷期:2011年128-10]
- Cancer-testis antigens (CTAs) are expressed mainly in various cancer tissues and in testis or placenta. Because of their restricted expression pattern, the CTAs can be potentially used for vaccine development and diagnos...
- Medical radiation exposure and risk of retinoblastoma resulting from new germline RB1 mutation
[作者:Bunin, GR; Felice, MA; Davidson, W; Friedman, DL; Shields, CL; Maidment, A; O'Shea, M; Nichols, KE; Leahey, A; Dunkel, IJ; Jubran, R; Rodriguez-Galindo, C; Schmidt, ML; Weinstein, JL; Goldman, S; Abramson, DH; Wilson, MW; Gallie, BL; Chan, HSL; Shapiro, M; Cnaan, A; Ganguly, A; Meadows, AT,期刊:International Journal of Cancer, 页码:2393-2404 , 文章类型: Article,,卷期:2011年128-10]
- Although ionizing radiation induces germline mutations in animals, human studies of radiation-exposed populations have not detected an effect. We conducted a case-control study of sporadic bilateral retinoblastoma, which...
- Exposure to house painting and the use of floor treatments and the risk of childhood acute lymphoblastic leukemia
[作者:Bailey, HD; Milne, E; de Klerk, NH; Fritschi, L; Attia, J; Cole, C; Armstrong, BK,期刊:International Journal of Cancer, 页码:2405-2414 , 文章类型: Article,,卷期:2011年128-10]
- Painting in the home has been identified as a potential risk factor for childhood acute lymphoblastic leukemia (ALL). The aim of this analysis was to investigate whether exposure to house painting or floor treatments bef...
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