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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共32条记录   The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin [作者：Velasquez, DA; Martinez, G; Romero, A; Vazquez, MJ; Boit, KD; Dopeso-Reyes, IG; Lopez, M; Vidal, A; Nogueiras, R; Dieguez, C,期刊：Diabetes, 页码：1177-1185 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-Ghrelin is a stomach-derived peptide that increases food intake through the activation of hypothalamic AMP-activated protein kinase (AMPK). However, the molecular mechanisms initiated by the activation of the g... GIP Does Not Potentiate the Antidiabetic Effects of GLP-1 in Hyperglycemic Patients With Type 2 Diabetes [作者：Mentis, N; Vardarli, I; Kothe, LD; Holst, JJ; Deacon, CF; Theodorakis, M; Meier, JJ; Nauck, MA,期刊：Diabetes, 页码：1270-1276 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-The incretin glucagon-like peptide 1 (GLP-1) exerts insulinotropic activity in type 2 diabetic patients, whereas glucose-dependent insulinotropic polypeptide (GIP) no longer does. We studied whether GIP can alt... Duration of Lactation and Maternal Adipokines at 3 Years Postpartum [作者：Stuebe, AM; Mantzoros, C; Kleinman, K; Gillman, MW; Rifas-Shiman, S; Gunderson, EP; Rich-Edwards, J,期刊：Diabetes, 页码：1277-1285 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-Lactation has been associated with reduced maternal risk of type 2 diabetes, the metabolic syndrome, and cardiovascular disease. We examined the relationship between breastfeeding duration and maternal adipokin... Cyclin-Dependent Kinase 5 Promotes Pancreatic beta-Cell Survival via Fak-Akt Signaling Pathways [作者：Daval, M; Gurlo, T; Costes, S; Huang, CJ; Butler, PC,期刊：Diabetes, 页码：1186-1197 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-Cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1 has recently been linked to type 2 diabetes by genome-wide association studies. While CDK5 and its regulatory protein p35 are both... Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic beta-Cells [作者：Kim, W; Doyle, ME; Liu, Z; Lao, QZ; Shin, YK; Carlson, OD; Kim, HS; Thomas, S; Napora, JK; Lee, EK; Moaddel, R; Wang, Y; Maudsley, S; Martin, B; Kulkarni, RN; Egan, JM,期刊：Diabetes, 页码：1198-1209 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-Optimal glucose homeostasis requires exquisitely precise adaptation of the number of insulin-secreting beta-cells in the islets of Langerhans. Insulin itself positively regulates beta-cell proliferation in an a... Role of Inflammation and Insulin Resistance in Endothelial Progenitor Cell Dysfunction [作者：Desouza, CV; Hamel, FG; Bidasee, K; O'Connell, K,期刊：Diabetes, 页码：1286-1294 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-Endothelial progenitor cells (EPCs) are decreased in number and function in type 2 diabetes. Mechanisms by which this dysfunction occurs are largely unknown. We tested the hypothesis that a chronic inflammatory... Delta 40 Isoform of p53 Controls beta-Cell Proliferation and Glucose Homeostasis in Mice [作者：Hinault, C; Kawamori, D; Liew, CW; Maier, B; Hu, JA; Keller, SR; Mirmira, RG; Scrable, H; Kulkarni, RN,期刊：Diabetes, 页码：1210-1222 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-Investigating the dynamics of pancreatic beta-cell mass is critical for developing strategies to treat both type 1 and type 2 diabetes. p53, a key regulator of the cell cycle and apoptosis, has mostly been a fo... In Vitro Recovery of ATP-Sensitive Potassium Channels in beta-Cells From Patients With Congenital Hyperinsulinism of Infancy [作者：Powell, PI; Bellanne-Chantelot, C; Flanagan, SE; Ellard, S; Rooman, R; Hussain, K; Skae, M; Clayton, P; de Lonlay, P; Dunne, MJ; Cosgrove, KE,期刊：Diabetes, 页码：1223-1228 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-Congenital hyperinsulinism in infancy (CHI) is characterized by unregulated insulin secretion from pancreatic beta-cells; severe forms are associated with defects in ABCC8 and KCNJ11 genes encoding sulfonylurea... Insulin Resistance Impairs Circulating Angiogenic Progenitor Cell Function and Delays Endothelial Regeneration [作者：Kahn, MB; Yuldasheva, NY; Cubbon, RM; Smith, J; Rashid, ST; Viswambharan, H; Imrie, H; Abbas, A; Rajwani, A; Aziz, A; Baliga, V; Sukumar, P; Gage, M; Kearney, MT; Wheatcroft, SB,期刊：Diabetes, 页码：1295-1303 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-Circulating angiogenic progenitor cells (APCs) participate in endothelial repair after arterial injury. Type 2 diabetes is associated with fewer circulating APCs, APC dysfunction, and impaired endothelial repai... Epigenetic Changes in Mitochondrial Superoxide Dismutase in the Retina and the Development of Diabetic Retinopathy [作者：Zhong, Q; Kowluru, RA,期刊：Diabetes, 页码：1304-1313 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-To investigate the role of epigenetic regulation of the manganese superoxide dismutase gene (sod2) in the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued pr... MicroRNA-200b Regulates Vascular Endothelial Growth Factor-Mediated Alterations in Diabetic Retinopathy [作者：McArthur, K; Feng, BA; Wu, YX; Chen, SL; Chakrabarti, S,期刊：Diabetes, 页码：1314-1323 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE Diabetic retinopathy (DR) is a leading cause of blindness. Increased vascular endothelial growth factor (VEGF), promoting angiogenesis and increased permeability, is a key mechanistic abnormality in DR. We inve... Partial Inhibition of Insulin Secretion Results in Glucose Intolerance but Not Hyperglucagonemia [作者：Ramanathan, RP; Arbelaez, AM; Cryer, PE,期刊：Diabetes, 页码：1324-1328 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE We tested the hypotheses that in nondiabetic individuals, partial inhibition of insulin secretion with the ATP-sensitive K+ channel agonist (opener) diazoxide, compared with placebo, results in higher plasma gl... A Bivariate Genome-Wide Approach to Metabolic Syndrome STAMPEED Consortium [作者：Kraja, AT; Vaidya, D; Pankow, JS; Goodarzi, MO; Assimes, TL; Kullo, IJ; Sovio, U; Mathias, RA; Sun, YV; Franceschini, N; Absher, D; Li, G; Zhang, QY; Feitosa, MF; Glazer, NL; Haritunians, T; Hartikainen, AL; Knowles, JW; North, KE; Iribarren, C; Kral, B; Yanek, L; O'Reilly, PF; McCarthy, MI; Jaquish, C; Couper, DJ; Chakravarti, A; Psaty, BM; Becker, LC; Province, MA; Boerwinkle, E; Quertermous, T; Palotie, L; Jarvelin, MR; Becker, DM; Kardia, SLR; Rotter, JI; Chen, YDI; Borecki, IB,期刊：Diabetes, 页码：1329-1339 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-The metabolic syndrome (MetS) is defined as concomitant disorders of lipid and glucose metabolism, central obesity, and high blood pressure, with an increased risk of type 2 diabetes and cardiovascular disease.... Updated Genetic Score Based on 34 Confirmed Type 2 Diabetes Loci Is Associated With Diabetes Incidence and Regression to Normoglycemia in the Diabetes Prevention Program [作者：Hivert, MF; Jablonski, KA; Perreault, L; Saxena, R; McAteer, JB; Franks, PW; Hamman, RF; Kahn, SE; Haffner, S; Meigs, JB; Altshuler, D; Knowler, WC; Florez, JC,期刊：Diabetes, 页码：1340-1348 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE Over 30 loci have been associated with risk of type 2 diabetes at genome-wide statistical significance. Genetic risk scores (GRSs) developed from these loci predict diabetes in the general population. We tested... Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3 [作者：Rubio-Cabezas, O; Jensen, JN; Hodgson, MI; Codner, E; Ellard, S; Serup, P; Hattersley, AT,期刊：Diabetes, 页码：1349-1353 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE-NEUROG3 plays a central role in the development of both pancreatic islets and enteroendocrine cells. Homozygous hypomorphic missense mutations in NEUROG3 have been recently associated with a rare form of congen... Unmasking Genes in a Type 1 Diabetes-Resistant Mouse Strain That Enhances Pathogenic CD8 T-Cell Responses [作者：Driver, JP; Chen, YG; Zhang, WD; Asrat, S; Serreze, DV,期刊：Diabetes, 页码：1354-1359 , 文章类型： Article，,卷期：2011年60-4] OBJECTIVE Nominally resistant mouse strains such as C57BL/6 (B6) harbor latent type 1 diabetes susceptibility genes uncovered in outcross to disease-susceptible NOD mice. However, identification of possible recessively a...