- Baicalin attenuates focal cerebral ischemic reperfusion injury through inhibition of nuclear factor kappa B p65 activation
[作者:Xue, X; Qu, XJ; Yang, Y; Sheng, XH; Cheng, F; Jiang, EN; Wang, JH; Bu, W; Liu, ZP,期刊:Biochemical and Biophysical Research Communications, 页码:398-404 , 文章类型: Article,,卷期:2010年403-3-4]
- Baicalin is a flavonoid compound purified from plant Scutellaria baicalensis Georgi. We aimed to evaluate the neuroprotective effects of baicalin against cerebral ischemic reperfusion injury. Male Wistar rats were subjec...
- MDM2 promotes the proteasomal degradation of p73 through the interaction with Itch in HeLa cells
[作者:Kubo, N; Okoshi, R; Nakashima, K; Shimozato, O; Nakagawara, A; Ozaki, T,期刊:Biochemical and Biophysical Research Communications, 页码:405-411 , 文章类型: Article,,卷期:2010年403-3-4]
- It has been shown that MDM2 inhibits the transcriptional and pro-apoptotic activities of p73 but does not promote its proteasomal degradation. In this study, we found that MDM2 indirectly induces the degradation of p73 t...
- Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection
[作者:Mwimanzi, P; Hasan, Z; Tokunaga, M; Gatanaga, H; Oka, S; Ueno, T,期刊:Biochemical and Biophysical Research Communications, 页码:422-427 , 文章类型: Article,,卷期:2010年403-3-4]
- HIV-1 Nef is a key factor for pathogenesis and is known to down-regulate functionally important molecules, including viral entry co-receptor CCR5 and CXCR4, from the surface of HIV-infected cells. Some of these Nef activ...
- H-1 NMR-based metabolomic study on resistance to diet-induced obesity in AHNAK knock-out mice
[作者:Kim, IY; Jung, J; Jang, M; Ahn, YG; Shin, JH; Choi, JW; Sohn, MR; Shin, SM; Kang, DG; Lee, HS; Bae, YS; Ryu, DH; Seong, JK; Hwang, GS,期刊:Biochemical and Biophysical Research Communications, 页码:428-434 , 文章类型: Article,,卷期:2010年403-3-4]
- AHNAK is a giant protein of approximately 700 kDa identified in human neuroblastomas and skin epithelial cells. Recently, we found that AHNAK knock-out (AHNAK(-/-)) mice have a strong resistance to high-fat diet-induced ...
- Engineered mutated glutaredoxins mimicking peculiar plant class III glutaredoxins bind iron-sulfur centers and possess reductase activity
[作者:Couturier, J; Didierjean, C; Jacquot, JP; Rouhier, N,期刊:Biochemical and Biophysical Research Communications, 页码:435-441 , 文章类型: Article,,卷期:2010年403-3-4]
- In order to gather biochemical information about class III glutaredoxins (CCxC/S active sites), the active sites of two poplar class I glutaredoxins, GrxC1 and C4, CGYC and CPYC, respectively, were transformed into CCMC ...
- Reexpression of ARHI inhibits tumor growth and angiogenesis and impairs the mTOR/VEGF pathway in hepatocellular carcinoma
[作者:Zhao, XH; Li, JF; Zhuo, JX; Cai, LX,期刊:Biochemical and Biophysical Research Communications, 页码:417-421 , 文章类型: Article,,卷期:2010年403-3-4]
- The Ras-related tumor suppressor gene aplasia Ras homolog member I (ARHI) is frequently downregulated in many types of cancer, including hepatocellular carcinoma (HCC). In this study, we sought to explore the therapeutic...
- Chromosome translocation and its consequence in the genome of Burkholderia cenocepacia AU-1054
[作者:Guo, FB; Ning, LW; Huang, JA; Lin, H; Zhang, HX,期刊:Biochemical and Biophysical Research Communications, 页码:375-379 , 文章类型: Article,,卷期:2010年403-3-4]
- Most bacterial genomes have one single chromosome. The species Burkholderia cenocepacia, a Gram-negative beta-proteobacterium, is one of the exceptions. Genomes of four strains of the species have been sequenced and each...
- Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells
[作者:Kikuta, K; Masamune, A; Watanabe, T; Ariga, H; Itoh, H; Hamada, S; Satoh, K; Egawa, S; Unno, M; Shimosegawa, T,期刊:Biochemical and Biophysical Research Communications, 页码:380-384 , 文章类型: Article,,卷期:2010年403-3-4]
- The interaction between pancreatic cancer cells and pancreatic stellate cells (PSCs), a major profibrogenic cell type in the pancreas, is receiving increasing attention. There is accumulating evidence that PSCs promote t...
- Evaluating reference genes to normalize gene expression in human epileptogenic brain tissues
[作者:Wierschke, S; Gigout, S; Horn, P; Lehmann, TN; Dehnicke, C; Brauer, AU; Deisz, RA,期刊:Biochemical and Biophysical Research Communications, 页码:385-390 , 文章类型: Article,,卷期:2010年403-3-4]
- Several reference genes have been used to quantify gene expression in human epilepsy surgery tissue. However, their reliability has not been validated in detail, although this is crucial in interpreting epilepsy-related ...
- The role of endogenous glucocorticoids in lymphocyte development in melanocortin receptor 2-deficient mice
[作者:Sato, Y; Suzuki, H; Sato, T; Suda, T; Yoda, T; Iwakura, Y; Chida, D,期刊:Biochemical and Biophysical Research Communications, 页码:253-257 , 文章类型: Article,,卷期:2010年403-3-4]
- Glucocorticoids are extensively used in anti-inflammatory therapy and are thought to contribute to the steady-state regulation of hematopoiesis and lymphopoiesis. We have previously established MC2R(-/-) mice, a model of...
- Nifedipine prevents vascular endothelial dysfunction in a mouse model of obesity and type 2 diabetes, by improving eNOS dysfunction and dephosphorylation
[作者:Yamamoto, E; Nakamura, T; Kataoka, K; Tokutomi, Y; Dong, YF; Fukuda, M; Nako, H; Yasuda, O; Ogawa, H; Kim-Mitsuyama, S,期刊:Biochemical and Biophysical Research Communications, 页码:258-263 , 文章类型: Article,,卷期:2010年403-3-4]
- The effect of calcium channel blockers (CCBs) on type 2 diabetes is still unclear. The present study was undertaken to examine the efficacy of nifedipine, a dihydropyridine CCB, on obesity, glucose intolerance and vascul...
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