- Attenuation of the Lysosomal Death Pathway by Lysosomal Cholesterol Accumulation
[作者:Appelqvist, H; Nilsson, C; Garner, B; Brown, AJ; Kagedal, K; Ollinger, K,期刊:American Journal of Pathology, 页码:629-639 , 文章类型: Article,,卷期:2011年178-2]
- In the past decade, lysosomal membrane permeabilization (LMP) has emerged as a significant component of cell death signaling. The mechanisms by which lysosomal stability is regulated are not yet fully understood, but cha...
- Mast Cells Are an Essential Component of Human Radiation Proctitis and Contribute to Experimental Colorectal Damage in Mice
[作者:Blirando, K; Milliat, F; Martelly, I; Sabourin, JC; Benderitter, M; Francois, A,期刊:American Journal of Pathology, 页码:640-651 , 文章类型: Article,,卷期:2011年178-2]
- Radiation proctitis is characterized by mucosal inflammation followed by adverse chronic tissue remodeling and is associated with substantial morbidity and mortality. Mast cell hyperplasia has been associated with diseas...
- DNA Methylation Suppresses Expression of the Urea Cycle Enzyme Carbamoyl Phosphate Synthetase 1 (CPS1) in Human Hepatocellular Carcinoma
[作者:Liu, HY; Dong, HJ; Robertson, K; Liu, C,期刊:American Journal of Pathology, 页码:652-661 , 文章类型: Article,,卷期:2011年178-2]
- Carbamoyl phosphate synthetase 1 (CPS1) is a liver-specific, intramitochondrial, rate-limiting enzyme in the urea cycle. A previous study showed that CPS1 is the antigen for hepatocyte paraffin 1 antibody, a commonly use...
- Serotonin Activates Dendritic Cell Function in the Context of Gut Inflammation
[作者:Li, N; Ghia, JE; Wang, HQ; McClemens, J; Cote, F; Suehiro, Y; Mallet, J; Khan, WI,期刊:American Journal of Pathology, 页码:662-671 , 文章类型: Article,,卷期:2011年178-2]
- Mucosal inflammation in the gut is characterized by infiltration of innate and adaptive immune cells and by an alteration in serotonin-producing enterochromaffin cells. We investigated the role of serotonin in the functi...
- Gastrin-Releasing Peptide Signaling Alters Colon Cancer Invasiveness via Heterochromatin Protein 1(Hs beta)
[作者:Tell, R; Rivera, CA; Eskra, J; Taglia, LN; Blunier, A; Wang, QT; Benya, RV,期刊:American Journal of Pathology, 页码:672-678 , 文章类型: Article,,卷期:2011年178-2]
- Epithelial cells lining the adult colon do not normally express gastrin-releasing peptide (GRP) or its receptor (GRPR). In contrast, GRP/GRPR can be aberrantly expressed in colon cancer where they are associated with imp...
- UV-B Radiation Induces Macrophage Migration Inhibitory Factor-Mediated Melanogenesis through Activation of Protease-Activated Receptor-2 and Stem Cell Factor in Keratinocytes
[作者:Enomoto, A; Yoshihisa, Y; Yamakoshi, T; Rehman, MU; Norisugi, O; Hara, H; Matsunaga, K; Makino, T; Nishihira, J; Shimizu, T,期刊:American Journal of Pathology, 页码:679-687 , 文章类型: Article,,卷期:2011年178-2]
- UV radiation indirectly regulates melanogenesis in melanocytes through a paracrine regulatory mechanism involving keratinocytes. Protease-activated receptor (PAR)-2 activation induces melanosome transfer by increasing ph...
- Overexpression of Pigment Epithelium-Derived Factor Inhibits Retinal Inflammation and Neovascularization
[作者:Park, K; Jin, J; Hu, Y; Zhou, KV; Ma, JX,期刊:American Journal of Pathology, 页码:688-698 , 文章类型: Article,,卷期:2011年178-2]
- Pigment epithelium-derived factor (PEDF) is a serine proteinase inhibitor with antiangiogenic activities. To investigate whether PEDF overexpression has an impact on ocular neovascularization in vivo, we generated PEDF t...
- Platelet-Activating Factor Blockade Inhibits the T-Helper Type 17 Cell Pathway and Suppresses Psoriasis-Like Skin Disease in K5.hTGF-beta 1 Transgenic Mice
[作者:Singh, TP; Huettner, B; Koefeler, H; Mayer, G; Bambach, I; Wallbrecht, K; Schon, MP; Wolf, P,期刊:American Journal of Pathology, 页码:699-708 , 文章类型: Article,,卷期:2011年178-2]
- Platelet-activating factor (PAF), a potent biolipid mediator, is involved in a variety of cellular transduction pathways and plays a prominent role in inducing inflammation in different organs. We used K5.hTGF-beta 1 tra...
- Differential Distribution and Phenotype of Decidual Macrophages in Preeclamptic versus Control Pregnancies
[作者:Schonkeren, D; van der Hoorn, ML; Khedoe, P; Swings, G; van Beelen, E; Claas, F; van Kooten, C; de Heer, E; Scherjon, S,期刊:American Journal of Pathology, 页码:709-717 , 文章类型: Article,,卷期:2011年178-2]
- Maternal immune tolerance of the semiallogeneic fetus is a complex phenomenon. Macrophages are an abundant cell population in the human decidua, and changes in distribution or phenotype may be involved in the development...
- IgG Autoantibodies Against Desmocollin 3 in Pemphigus Sera Induce Loss of Keratinocyte Adhesion
[作者:Rafei, D; Muller, R; Ishii, N; Llamazares, M; Hashimoto, T; Hertl, M; Eming, R,期刊:American Journal of Pathology, 页码:718-723 , 文章类型: Article,,卷期:2011年178-2]
- Pemphigus is considered an autoimmune bullous skin disorder associated with IgG against the desmosomal components, desmoglein 3 (Dsg3) and desmoglein 1 (Dsg1). This concept is supported by the in vitro and in vivo pathog...
- CD14 Signaling Reciprocally Controls Collagen Deposition and Turnover to Regulate the Development of Lyme Arthritis
[作者:Sahay, B; Singh, A; Gnanamani, A; Patsey, RL; Blalock, JE; Sellati, TJ,期刊:American Journal of Pathology, 页码:724-734 , 文章类型: Article,,卷期:2011年178-2]
- CD14 is a glycosylphosphatidylinositol-anchored protein expressed primarily on myeloid cells (eg, neutrophils, macrophages, and dendritic cells). CD14(-/-) mice infected with Borrelia burgdorferi, the causative agent of ...
- IL-10-Producing Regulatory B10 Cells Inhibit Intestinal Injury in a Mouse Model
[作者:Yanaba, K; Yoshizaki, A; Asano, Y; Kadono, T; Tedder, TF; Sato, S,期刊:American Journal of Pathology, 页码:735-743 , 文章类型: Article,,卷期:2011年178-2]
- B cells mediate multiple functions that influence immune and inflammatory responses. In mice, the addition of dextran sulfate sodium (DSS) to drinking water leads to immediate intestinal injury. Dextran sulfate sodium-in...
- Antigen Presentation and MHC Class II Expression by Human Esophageal Epithelial Cells Role in Eosinophilic Esophagitis
[作者:Mulder, DJ; Pooni, A; Mak, N; Hurlbut, DJ; Basta, S; Justinich, CJ,期刊:American Journal of Pathology, 页码:744-753 , 文章类型: Article,,卷期:2011年178-2]
- Professional antigen-presenting cells (APCs) play a crucial role in initiating immune responses. Under pathological conditions, epithelial cells at mucosal surfaces act as nonprofessional APCs, thereby regulating immune ...
- Tenascin C Induces Epithelial-Mesenchymal Transition-Like Change Accompanied by SRC Activation and Focal Adhesion Kinase Phosphorylation in Human Breast Cancer Cells
[作者:Nagaharu, K; Zhang, XH; Yoshida, T; Katoh, D; Hanamura, N; Kozuka, Y; Ogawa, T; Shiraishi, T; Imanaka-Yoshida, K,期刊:American Journal of Pathology, 页码:754-763 , 文章类型: Article,,卷期:2011年178-2]
- Tenascin C (TNC) is an extracellular matrix glycoprotein up-regulated in solid tumors. Higher TNC expression is shown in invading fronts of breast cancer, which correlates with poorer patient outcome. We examined whether...
- Elastin Degradation and Vascular Smooth Muscle Cell Phenotype Change Precede Cell Loss and Arterial Medial Calcification in a Uremic Mouse Model of Chronic Kidney Disease
[作者:Pai, A; Leaf, EM; El-Abbadi, M; Giachelli, CM,期刊:American Journal of Pathology, 页码:764-773 , 文章类型: Article,,卷期:2011年178-2]
- Arterial medial calcification (AMC), a hallmark of vascular disease in uremic patients, is highly correlated with serum phosphate levels and cardiovascular mortality. To determine the mechanisms of AMC, mice were made ur...
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