- Identification of Transmembrane Protein 88 (TMEM88) as a Dishevelled-binding Protein
[作者:Lee, HJ; Finkelstein, D; Li, XF; Wu, DQ; Shi, DL; Zheng, JJ,期刊:Journal of Biological Chemistry, 页码:41549-41556 , 文章类型: Article,,卷期:2010年285-53]
- Wnt signaling pathways are involved in embryonic development and adult tissue maintenance and have been implicated in tumorigenesis. Dishevelled (Dvl/Dsh) protein is one of key components in Wnt signaling and plays essen...
- Moonlighting Glutamate Formiminotransferases Can Functionally Replace 5-Formyltetrahydrofolate Cycloligase
[作者:Jeanguenin, L; Lara-Nunez, A; Pribat, A; Mageroy, MH; Gregory, JF; Rice, KC; de Crecy-Lagard, V; Hanson, AD,期刊:Journal of Biological Chemistry, 页码:41557-41566 , 文章类型: Article,,卷期:2010年285-53]
- 5-Formyltetrahydrofolate (5-CHO-THF) is formed by a side reaction of serine hydroxymethyltransferase. Unlike other folates, it is not a one-carbon donor but a potent inhibitor of folate enzymes and must therefore be meta...
- Intrarenal Renin Angiotensin System Revisited ROLE OF MEGALIN-DEPENDENT ENDOCYTOSIS ALONG THE PROXIMAL NEPHRON
[作者:Pohl, M; Kaminski, H; Castrop, H; Bader, M; Himmerkus, N; Bleich, M; Bachmann, S; Theilig, F,期刊:Journal of Biological Chemistry, 页码:41935-41946 , 文章类型: Article,,卷期:2010年285-53]
- The existence of a local renin angiotensin system (RAS) of the kidney has been established. Angiotensinogen (AGT), renin, angiotensin-converting enzyme (ACE), angiotensin receptors, and high concentrations of luminal ang...
- Interruption of Inositol Sphingolipid Synthesis Triggers Stt4p-dependent Protein Kinase C Signaling
[作者:Jesch, SA; Gaspar, ML; Stefan, CJ; Aregullin, MA; Henry, SA,期刊:Journal of Biological Chemistry, 页码:41947-41960 , 文章类型: Article,,卷期:2010年285-53]
- The protein kinase C (PKC)-MAPK signaling cascade is activated and is essential for viability when cells are starved for the phospholipid precursor inositol. In this study, we report that inhibiting inositol-containing s...
- Bacillus subtilis CwlP of the SP-beta Prophage Has Two Novel Peptidoglycan Hydrolase Domains, Muramidase and Cross-linkage Digesting DD-Endopeptidase
[作者:Sudiarta, IP; Fukushima, T; Sekiguchi, J,期刊:Journal of Biological Chemistry, 页码:41232-41243 , 文章类型: Article,,卷期:2010年285-53]
- For bacteria and bacteriophages, cell wall digestion by hydrolases is a very important event. We investigated one of the proteins involved in cell wall digestion, the yomI gene product (renamed CwlP). The gene is located...
- omega-Oxidation of alpha-Chlorinated Fatty Acids IDENTIFICATION OF alpha-CHLORINATED DICARBOXYLIC ACIDS
[作者:Brahmbhatt, VV; Albert, CJ; Anbukumar, DS; Cunningham, BA; Neumann, WL; Ford, DA,期刊:Journal of Biological Chemistry, 页码:41255-41269 , 文章类型: Article,,卷期:2010年285-53]
- Myeloperoxidase-derived HOCl targets tissue-and lipoprotein-associated plasmalogens to generate alpha-chlorinated fatty aldehydes, including 2-chlorohexadecanal. Under physiological conditions, 2-chlorohexadecanal is oxi...
- Regulation of Angiogenesis by Histone Chaperone HIRA-mediated Incorporation of Lysine 56-acetylated Histone H3.3 at Chromatin Domains of Endothelial Genes
[作者:Dutta, D; Ray, S; Home, P; Saha, B; Wang, SJ; Sheibani, N; Tawfik, O; Cheng, NK; Paul, S,期刊:Journal of Biological Chemistry, 页码:41567-41577 , 文章类型: Article,,卷期:2010年285-53]
- Angiogenesis is critically dependent on endothelial cell-specific transcriptional mechanisms. However, the molecular processes that regulate chromatin domains and thereby dictate transcription of key endothelial genes ar...
- Ligand-induced Internalization and Recycling of the Human Neuropeptide Y-2 Receptor Is Regulated by Its Carboxyl-terminal Tail
[作者:Walther, C; Nagel, S; Gimenez, LE; Morl, K; Gurevich, VV; Beck-Sickinger, AG,期刊:Journal of Biological Chemistry, 页码:41578-41590 , 文章类型: Article,,卷期:2010年285-53]
- Agonist-induced internalization of G protein-coupled receptors plays an important role in signal regulation. The underlying mechanisms of the internalization of the human neuropeptide Y-2 receptor (hY(2)R), as well as it...
- Identification of MicroRNAs Regulating Reprogramming Factor LIN28 in Embryonic Stem Cells and Cancer Cells
[作者:Zhong, XM; Li, N; Liang, S; Huang, QH; Coukos, G; Zhang, L,期刊:Journal of Biological Chemistry, 页码:41961-41971 , 文章类型: Article,,卷期:2010年285-53]
- LIN28 (a homologue of the Caenorhabditis elegans lin-28 gene) is an evolutionarily conserved RNA-binding protein and a master regulator controlling the pluripotency of embryonic stem cells. Together with OCT4, SOX2, and ...
- Quality Control of Photosystem II FtsH HEXAMERS ARE LOCALIZED NEAR PHOTOSYSTEM II AT GRANA FOR THE SWIFT REPAIR OF DAMAGE
[作者:Yoshioka, M; Nakayama, Y; Yoshida, M; Ohashi, K; Morita, N; Kobayashi, H; Yamamoto, Y,期刊:Journal of Biological Chemistry, 页码:41972-41981 , 文章类型: Article,,卷期:2010年285-53]
- The reaction center-binding D1 protein of Photosystem II is oxidatively damaged by excessive visible light or moderate heat stress. The metalloprotease FtsH has been suggested as responsible for the degradation of the D1...
- Thrombin-dependent MMP-2 Activity Is Regulated by Heparan Sulfate
[作者:Koo, BH; Han, JH; Il Yeom, Y; Kim, DS,期刊:Journal of Biological Chemistry, 页码:41270-41279 , 文章类型: Article,,卷期:2010年285-53]
- Like most metalloproteases, matrix metalloprotease 2 (MMP-2) is synthesized as a zymogen. MMP-2 propeptide plays a role in inhibition of catalytic activity through a cysteine-zinc ion pairing, disruption of which results...
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