A new synthetic protocol for carbazoles through gold(I)catalyzed intramolecular hydroarylation of (Z)-2-(enynyl) indoles was achieved in good yields. The requisite (Z)-2-(enynyl) indoles were synthesized stereoselectivel...
An efficient and simple method for the synthesis of various iodo-substituted dihydropyridocarbazole derivatives has been developed via iodocyclization of N-propargylated 3-aminocarbazoles.
An asymmetric synthesis of di-and trisubstituted cyclopropanes proceeding through an intramolecular ring closure of activated chiral benzyl alcohols has been developed. The chiral alcohol intermediates are obtained from ...
The first enantioselective synthesis of planar chiral [7] and [8]paracyclophanes has been achieved by the cationic rhodium(I)-(S)-H-8-BINAP complex catalyzed [2+2+2] cycloaddition. Planar chiral [9]paracyclophanes were a...
N-tert-Butoxycarbonylcarbamates of a-amino acid derivatives underwent asymmetric carbonyl migration by treatment with KHMDS in DMF to give a-amino acid derivatives with an additional ester group at the newly formed tetra...
The total synthesis of amphilectane-type diterpenoid (+/-)-7- isocyanoamphilecta-11(20),15-diene, isolated from the tropical marine sponge Cymbastela hooperi, was achieved. The synthesis involves construction of a cis-de...
Rasta resin-PPh3BnCl, a new heterogeneous polystyrene-based phosphonium salt, has been synthesized and used to catalyze cyanosilylation reactions of aldehydes and ketones. It was found to be more efficient as a catalyst ...
The ternary H2O2-AcOH-NaBr combination has been found to be extremely effective for the oxidation of benzyl alcohol and its derivatives. Comparative studies indicated that the addition of NaBr offered significant improve...
An efficient oxidation of sulfides with air catalyzed by the combination of potassium nitrate with pyridinium tribromide under transition-metal-free conditions was reported. By replacing pyridinium tribromide with bromin...
The synthesis of a plausible key intermediate for a biomimetic asymmetric synthesis of indole alkaloid arboflorine is described. The method featured the use of Ellman's sulfinamide chemistry for the establishment of the ...
A copper-catalyzed N-N bond-forming reaction was performed by a dehydrogenative homocoupling of N-alkylanilines, affording N, N'-dialkyl-N, N'-diphenylhydrazines in 72-88% yields. This new strategy has the advantages of ...
An acid-catalysed conversion of N-arylcarboxy-4-quinazolinones into 2-(2-aminoaryl)-4(1H)-quinazolinones has been observed. This reaction allows for a nucleophilic aromatic substitution reaction between aminobenzoic acid...
L-Lemonose, the glycosidic part of (-)-lemonomycin, has been synthesized in ten steps with 18% overall yield from D-threonine. The key steps are a double, highly diastereoselective Grignard addition to a Weinreb amide an...
The palladium-catalyzed reaction of olefins with PhI(OAc)(2)-TBAB system provides a novel, efficient, and highly selective bisfunctionalization strategy to introduce bromo and oxygen groups simultaneously. The substituen...
Direct reductive transformation of triphenylphosphine oxide to triphenylphosphine was performed successfully by electrolysis with TMSCl in an acetonitrile/Bu4NBr/(Zn anode)-(Pt cathode)/undivided cell/constant current el...