- Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance
[作者：Kang, HS; Okamoto, K; Kim, YS; Takeda, Y; Bortner, CD; Dang, HX; Wada, T; Xie, W; Yang, XP; Liao, G; Jetten, AM,期刊：Diabetes, 页码：177-188 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE The nuclear receptor TAK1/TR4/NR2C2 is expressed in several tissues that are important in the control of energy homeostasis. In this study, we investigate whether TAK1 functions as a regulator of lipid and ener...
- P-Selectin Glycoprotein Ligand-1 Deficiency Is Protective Against Obesity-Related Insulin Resistance
[作者：Sato, C; Shikata, K; Hirota, D; Sasaki, M; Nishishita, S; Miyamoto, S; Kodera, R; Ogawa, D; Tone, A; Kataoka, HU; Wada, J; Kajitani, N; Makino, H,期刊：Diabetes, 页码：189-199 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE An inflammatory process is involved in the mechanism of obesity-related insulin resistance. Recent studies indicate that monocyte chemoattractant protein-1 (MCP-1) is a major chemokine that promotes monocyte in...
- Congenital Hyperinsulinism and Glucose Hypersensitivity in Homozygous and Heterozygous Carriers of Kir6.2 (KCNJ11) Mutation V290M Mutation K-ATP Channel Inactivation Mechanism and Clinical Management
[作者：Loechner, KJ; Akrouh, A; Kurata, HT; Dionisi-Vici, C; Maiorana, A; Pizzoferro, M; Rufini, V; de Goyet, JD; Colombo, C; Barbetti, F; Koster, JC; Nichols, CG,期刊：Diabetes, 页码：209-217 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-The ATP-sensitive K+ channel (K-ATP) controls insulin secretion from the islet. Gain- or loss-of-function mutations in channel subunits underlie human neonatal diabetes and congenital hyperinsulinism (HI), resp...
- Exendin-4 Suppresses Src Activation and Reactive Oxygen Species Production in Diabetic Goto-Kakizaki Rat Islets in an Epac-Dependent Manner
[作者：Mukai, E; Fujimoto, S; Sato, H; Oneyama, C; Kominato, R; Sato, Y; Sasaki, M; Nishi, Y; Okada, M; Inagaki, N,期刊：Diabetes, 页码：218-226 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-Reactive oxygen species (ROS) is one of most important factors in impaired metabolism secretion coupling in pancreatic beta-cells. We recently reported that elevated ROS production and impaired ATP production a...
- beta-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 Deficiency
[作者：Costes, S; Huang, CJ; Gurlo, T; Dava, M; Matveyenko, MV; Rizza, RA; Butler, AE; Butler, PC,期刊：Diabetes, 页码：227-238 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-The islet in type 2 diabetes is characterized by beta-cell apoptosis, beta-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (TAPP). Toxic oligomers of IAPP fo...
- Production of Functional Glucagon-Secreting alpha-Cells From Human Embryonic Stem Cells
[作者：Rezania, A; Riedel, MJ; Wideman, RD; Karanu, F; Ao, ZL; Warnock, GL; Kieffer, TJ,期刊：Diabetes, 页码：239-247 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-Differentiation of human embryonic stem (hES) cells to fully developed cell types holds great therapeutic promise. Despite significant progress, the conversion of hES cells to stable, fully differentiated endoc...
- Interleukin-1 beta Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells Implications for the Timing of Tolerizing Immunotherapy
[作者：Bertin-Maghit, S; Pang, DM; O'Sullivan, B; Best, S; Duggan, E; Paul, S; Thomas, H; Kay, TWH; Harrison, LC; Steptoe, R; Thomas, R,期刊：Diabetes, 页码：248-257 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-The effectiveness of tolerizing immunotherapeutic strategies, such as anti-CD40L or dendritic cells (DCs), is greater when administered to young nonobese diabetic (NOD) mice than at peak insulitis. RelB(lo) DCs...
- FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction
[作者：Bravard, A; Lefai, E; Meugnier, E; Pesenti, S; Disse, E; Vouillarmet, J; Peretti, N; Rabasa-Lhoret, R; Laville, M; Vidal, H; Rieusset, J,期刊：Diabetes, 页码：258-268 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-A strong association between genetic variants and obesity was found for the fat mass and obesity-associated gene (FTO). However, few details are known concerning the expression and function of FTO in skeletal m...
- Coffee and Caffeine Consumption in Relation to Sex Hormone-Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women
[作者：Goto, A; Song, YQ; Chen, BH; Manson, JE; Buring, JE; Liu, SM,期刊：Diabetes, 页码：269-275 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-Coffee consumption has been inversely associated with type 2 diabetes risk, but its mechanisms are largely unknown. We aimed to examine whether plasma levels of sex hormones and sex hormone-binding globulin (SH...
- Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes
[作者：Oikarinen, S; Martiskainen, M; Tauriainen, S; Huhtala, H; Ilonen, J; Veijola, R; Simell, O; Knip, M; Hyoty, H,期刊：Diabetes, 页码：276-279 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-To assess whether the detection of enterovirus RNA in blood predicts the development of clinical type 1 diabetes in a prospective birth cohort study. Further, to study the role of enteroviruses in both the init...
- miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-beta 2 Expression
[作者：Wang, B; Koh, P; Winbanks, C; Coughlan, MT; McClelland, A; Watson, A; Jandeleit-Dahm, K; Burns, WC; Thomas, MC; Cooper, ME; Kantharidis, P,期刊：Diabetes, 页码：280-287 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-Progressive fibrosis in the diabetic kidney is driven and sustained by a diverse range of profibrotic factors. This study examines the critical role of microRNAs (miRNAs) in the regulation of the key fibrotic m...
- Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats
[作者：Akude, E; Zherebitskaya, E; Chowdhury, SKR; Smith, DR; Dobrowsky, RT; Fernyhough, P,期刊：Diabetes, 页码：288-297 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-Impairments in mitochondrial function have been proposed to play a role in the etiology of diabetic sensory neuropathy. We tested the hypothesis that mitochondrial dysfunction in axons of sensory neurons in typ...
- Glycated Hemoglobin and the Risk of Kidney Disease and Retinopathy in Adults With and Without Diabetes
[作者：Selvin, E; Ning, Y; Steffes, MW; Bash, LD; Klein, R; Wong, TY; Astor, BC; Sharrett, AR; Brancati, FL; Coresh, J,期刊：Diabetes, 页码：298-305 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-Glycated hemoglobin was recently recommended for use as a diagnostic test for diabetes. We examined the association between 2010 American Diabetes Association diagnostic cut points for glycated hemoglobin and m...
- Insulin Resistance, Defective Insulin-Mediated Fatty Acid Suppression, and Coronary Artery Calcification in Subjects With and Without Type 1 Diabetes The CACTI Study
[作者：Schauer, IE; Snell-Bergeon, JK; Bergman, BC; Maahs, DM; Kretowski, A; Eckel, RH; Rewers, M,期刊：Diabetes, 页码：306-314 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-To assess insulin action on peripheral glucose utilization and nonesterified fatty acid (NEFA) suppression as a predictor of coronary artery calcification (CAC) in patients with type 1 diabetes and nondiabetic ...
- High Connectivity Between Reduced Cortical Thickness and Disrupted White Matter Tracts in Long-Standing Type 1 Diabetes
[作者：Franc, DT; Kodl, CT; Mueller, BA; Muetzel, RL; Lim, KO; Seaquist, ER,期刊：Diabetes, 页码：315-319 , 文章类型： Article，,卷期：2011年60-1]
- OBJECTIVE-Previous studies have observed disruptions in brain white and gray matter structure in individuals with type 1 diabetes, and these structural differences have been associated with neurocognitive testing deficie...
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