- Extracellular 2 '-5 ' Oligoadenylate Synthetase Stimulates RNase L-Independent Antiviral Activity: a Novel Mechanism of Virus-Induced Innate Immunity
[作者:Kristiansen, H; Scherer, CA; McVean, M; Iadonato, SP; Vends, S; Thavachelvam, K; Steffensen, TB; Horan, KA; Kuri, T; Weber, F; Paludan, SR; Hartmann, R,期刊:Journal of virology, 页码:11898-11904 , 文章类型: Article,,卷期:2010年84-22]
- The 2'-5' oligoadenylate synthetase (OAS) proteins are traditionally considered intracellular antiviral proteins. However, several studies demonstrate a correlation between the concentration of freely circulating OAS pro...
- Immunization with Plant-Expressed Hemagglutinin Protects Chickens from Lethal Highly Pathogenic Avian Influenza Virus H5N1 Challenge Infection
[作者:Kalthoff, D; Giritch, A; Geisler, K; Bettmann, U; Klimyuk, V; Hehnen, HR; Gleba, Y; Beer, M,期刊:Journal of virology, 页码:12002-12010 , 文章类型: Article,,卷期:2010年84-22]
- Highly pathogenic avian influenza (HPAI) is a striking disease in susceptible poultry, which leads to severe economic losses. Inactivated vaccines are the most widely used vaccines in avian influenza virus (AIV) vaccinat...
- Dendritic Cell Activation by Recombinant Hemagglutinin Proteins of H1N1 and H5N1 Influenza A Viruses
[作者:Liu, WC; Lin, SC; Yu, YL; Chu, CL; Wu, SC,期刊:Journal of virology, 页码:12011-12017 , 文章类型: Article,,卷期:2010年84-22]
- Since dendritic cells may play a key role in defense against influenza virus infection, we examined the effects of recombinant hemagglutinin (HA) proteins derived from mouse-adapted H1N1 (A/WSN/1933), swine-origin 2009 p...
- Distinct Stability States of Disease-Associated Human Prion Protein Identified by Conformation-Dependent Immunoassay
[作者:Choi, YP; Peden, AH; Groner, A; Ironside, JW; Head, MW,期刊:Journal of virology, 页码:12030-12038 , 文章类型: Article,,卷期:2010年84-22]
- The phenotypic and strain-related properties of human prion diseases are, according to the prion hypothesis, proposed to reside in the physicochemical properties of the conformationally altered, disease-associated isofor...
- Histone Deacetylases and the Nuclear Receptor Corepressor Regulate Lytic-Latent Switch Gene 50 in Murine Gammaherpesvirus 68-Infected Macrophages
[作者:Goodwin, MM; Molleston, JM; Canny, S; Abou El Hassan, M; Willert, EK; Bremner, R; Virgin, HW,期刊:Journal of virology, 页码:12039-12047 , 文章类型: Article,,卷期:2010年84-22]
- Gammaherpesviruses are important oncogenic pathogens that transit between lytic and latent life cycles. Silencing the lytic gene expression program enables the establishment of latency and a lifelong chronic infection of...
- Infectivity of Hepatitis C Virus Is Influenced by Association with Apolipoprotein E Isoforms
[作者:Hishiki, T; Shimizu, Y; Tobita, R; Sugiyama, K; Ogawa, K; Funami, K; Ohsaki, Y; Fujimoto, T; Takaku, H; Wakita, T; Baumert, TF; Miyanari, Y; Shimotohno, K,期刊:Journal of virology, 页码:12048-12057 , 文章类型: Article,,卷期:2010年84-22]
- Hepatitis C virus (HCV) is a causative agent of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. HCV in circulating blood associates with lipoproteins such as very low density lipoprotein (VLDL) and low-...
- Altered Receptor Specificity and Cell Tropism of D222G Hemagglutinin Mutants Isolated from Fatal Cases of Pandemic A(H1N1) 2009 Influenza Virus
[作者:Liu, Y; Childs, RA; Matrosovich, T; Wharton, S; Palma, AS; Chai, WG; Daniels, R; Gregory, V; Uhlendorff, J; Kiso, M; Klenk, HD; Hay, A; Feizi, T; Matrosovich, M,期刊:Journal of virology, 页码:12069-12074 , 文章类型: Article,,卷期:2010年84-22]
- Mutations in the receptor-binding site of the hemagglutinin of pandemic influenza A(H1N1) 2009 viruses have been detected sporadically. An Asp222Gly (D222G) substitution has been associated with severe or fatal disease. ...
- Generation of Replication-Competent Recombinant Influenza A Viruses Carrying a Reporter Gene Harbored in the Neuraminidase Segment
[作者:Li, F; Feng, LQ; Pan, WQ; Dong, ZY; Li, CF; Sun, CJ; Chen, L,期刊:Journal of virology, 页码:12075-12081 , 文章类型: Article,,卷期:2010年84-22]
- Replication-competent influenza viruses carrying reporter genes are of great use for basic research, screening of antiviral drugs, and neutralizing of antibodies. In this study, two recombinant influenza A viruses with a...
- Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection
[作者:Murray, SM; Down, CM; Boulware, DR; Stauffer, WM; Cavert, WP; Schacker, TW; Brenchley, JM; Douek, DC,期刊:Journal of virology, 页码:12082-12086 , 文章类型: Article,,卷期:2010年84-22]
- Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potenti...
- Whole-Genome Characterization of Human and Simian Immunodeficiency Virus Intrahost Diversity by Ultradeep Pyrosequencing
[作者:Bimber, BN; Dudley, DM; Lauck, M; Becker, EA; Chin, EN; Lank, SM; Grunenwald, HL; Caruccio, NC; Maffitt, M; Wilson, NA; Reed, JS; Sosman, JM; Tarosso, LF; Sanabani, S; Kallas, EG; Hughes, AL; O'Connor, DH,期刊:Journal of virology, 页码:12087-12092 , 文章类型: Article,,卷期:2010年84-22]
- Rapid evolution and high intrahost sequence diversity are hallmarks of human and simian immunodeficiency virus (HIV/SIV) infection. Minor viral variants have important implications for drug resistance, receptor tropism, ...
- Stimulation of Human Dendritic Cells by Wild-Type and M Protein Mutant Vesicular Stomatitis Viruses Engineered To Express Bacterial Flagellin
[作者:Ahmed, M; Puckett, S; Arimilli, S; Braxton, CL; Mizel, SB; Lyles, DS,期刊:Journal of virology, 页码:12093-12098 , 文章类型: Article,,卷期:2010年84-22]
- Vesicular stomatitis viruses (VSVs) containing wild-type (wt) or mutant matrix (M) proteins are being developed as candidate vaccine vectors due to their ability to induce innate and adaptive immunity. Viruses with wt M ...
- In Vitro Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors
[作者:Koh, Y; Amano, M; Towata, T; Danish, M; Leshchenko-Yashchuk, S; Das, D; Nakayama, M; Tojo, Y; Ghosh, AK; Mitsuya, H,期刊:Journal of virology, 页码:11961-11969 , 文章类型: Article,,卷期:2010年84-22]
- We attempted to select HIV-1 variants resistant to darunavir (DRV), which potently inhibits the enzymatic activity and dimerization of protease and has a high genetic barrier to HIV-1 development of resistance to DRV. We...
- Evolution of Functional and Sequence Variants of the Mammalian XPR1 Receptor for Mouse Xenotropic Gammaretroviruses and the Human-Derived Retrovirus XMRV
[作者:Yan, YH; Liu, QP; Wollenberg, K; Martin, C; Buckler-White, A; Kozak, CA,期刊:Journal of virology, 页码:11970-11980 , 文章类型: Article,,卷期:2010年84-22]
- Genetic conflicts between retroviruses and their receptors result in the evolution of novel host entry restrictions and novel virus envelopes, and such variants can influence trans-species transmission. We screened roden...
- The HIV-1 Central Polypurine Tract Functions as a Second Line of Defense against APOBEC3G/F
[作者:Hu, CL; Saenz, DT; Fadel, HJ; Walker, W; Peretz, M; Poeschla, EM,期刊:Journal of virology, 页码:11981-11993 , 文章类型: Article,,卷期:2010年84-22]
- HIV-1 and certain other retroviruses initiate plus-strand synthesis in the center of the genome as well as at the standard retroviral 3' polypurine tract. This peculiarity of reverse transcription results in a central DN...
- Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression
[作者:Mlotshwa, M; Riou, C; Chopera, D; Rosa, DD; Ntale, R; Treunicht, F; Woodman, Z; Werner, L; van Loggerenberg, F; Mlisana, K; Karim, SA; Williamson, C; Gray, CM,期刊:Journal of virology, 页码:12018-12029 , 文章类型: Article,,卷期:2010年84-22]
- Deciphering immune events during early stages of human immunodeficiency virus type 1 (HIV-1) infection is critical for understanding the course of disease. We characterized the hierarchy of HIV-1-specific T-cell gamma in...
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