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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共42条记录   Can TNF-alpha boost regulatory T cells? [作者：Bilate, AM; Lafaille, JJ,期刊：Journal of clinical investigation, 页码：4190-4192 , 文章类型： Editorial Material，,卷期：2010年120-12] Deleterious immune responses that cause autoimmune diseases such as type 1 diabetes are normally kept m check by a myriad of mechanisms Among these, protection mediated by CD4(+)Foxp3(+) Tregs constitutes an essential pa... Can we build it better? Using BAC genetics to engineer more effective cytomegalovirus vaccines [作者：Schleiss, MR,期刊：Journal of clinical investigation, 页码：4192-4197 , 文章类型： Editorial Material，,卷期：2010年120-12] The magnitude and durability of immunity to human cytomegalovirus (HCMV) following natural infection is compromised by the presence of immune modulation genes that appear to promote evasion of host clearance mechanisms S... Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure? [作者：Eschenhagen, T,期刊：Journal of clinical investigation, 页码：4197-4203 , 文章类型： Editorial Material，,卷期：2010年120-12] In situations of stress the heart beats faster and stronger According to Marks and colleagues, this response is, to a large extent, the consequence of facilitated Ca2+ release from intracellular Ca2+ stores via ryanodine... Learning about genomics and disease from the anucleate human red blood cell [作者：Benz, EJ,期刊：Journal of clinical investigation, 页码：4204-4206 , 文章类型： Editorial Material，,卷期：2010年120-12] During the differentiation of an erythrocyte, the developing erythroblast shuts down expression of most of its genes but preserves high levels of expression of certain key genes, such as those encoding hemoglobin and cri... Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice [作者：Marrotte, EJ; Chen, DD; Hakim, JS; Chen, AF,期刊：Journal of clinical investigation, 页码：4207-4219 , 文章类型： Article，,卷期：2010年120-12] Amputation as a result of impaired wound healing is a serious complication of diabetes Inadequate angiogenesis contributes to poor wound healing in diabetic patients Endothelial progenitor cells (EPCs) normally augment a... alpha-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8 [作者：Bergin, DA; Reeves, EP; Meleady, P; Henry, M; McElvaney, OJ; Carroll, TP; Condron, C; Chotirmall, SH; Clynes, M; O'Neill, SJ; McElvaney, NG,期刊：Journal of clinical investigation, 页码：4236-4250 , 文章类型： Article，,卷期：2010年120-12] Hereditary deficiency of the protein alpha-1 antitrypsin (AAT) causes a chronic lung disease in humans that is characterized by excessive mobilization of neutrophils into the lung However, the reason for the increased ne... The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis [作者：Moreth, K; Brodbeck, R; Babelova, A; Gretz, N; Spieker, T; Zeng-Brouwers, J; Pfeilschifter, J; Young, MF; Schaefer, RM; Schaefer, L,期刊：Journal of clinical investigation, 页码：4251-4272 , 文章类型： Article，,卷期：2010年120-12] CXCL13 is a key B cell chemoattractant and marker of disease activity in patients with SLE, however, the mechanism of its induction has not been identified yet. Here, we have shown that the proteoglycan biglycan triggers... Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis [作者：Ben-Batalla, I; Seoane, S; Garcia-Caballero, T; Gallego, R; Macia, M; Gonzalez, LO; Vizoso, F; Perez-Fernandez, R,期刊：Journal of clinical investigation, 页码：4289-4302 , 文章类型： Article，,卷期：2010年120-12] The Pit-1 transcription factor (also know as POU1F1) plays a critical role in cell differentiation during organogenesis of the anterior pituitary in mammals and is a transcriptional activator for pituitary gene transcrip... Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice [作者：Shinnick, KM; Eklund, EA; McGarry, TJ,期刊：Journal of clinical investigation, 页码：4303-4315 , 文章类型： Article，,卷期：2010年120-12] HSCs maintain the circulating blood cell population Defects in the orderly pattern of hematopoietic cell division and differentiation can lead to leukemia, myeloproliferative disorders, or marrow failure, however, the fa... Vancomycin-resistant Enterococcus domination of intestinal microbiota is enabled by antibiotic treatment in mice and precedes bloodstream invasion in humans [作者：Ubeda, C; Taur, Y; Jenq, RR; Equinda, MJ; Son, T; Samstein, M; Viale, A; Socci, ND; van den Brink, MRM; Kamboj, M; Pamer, EG,期刊：Journal of clinical investigation, 页码：4332-4341 , 文章类型： Article，,卷期：2010年120-12] Bloodstream infection by highly antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), is a growing clinical problem that increasingly defies medical intervention Identifying patients at high ris... T-cadherin is critical for adiponectin-mediated cardioprotection in mice [作者：Denzel, MS; Scimia, MC; Zumstein, PM; Walsh, K; Ruiz-Lozano, P; Ranscht, B,期刊：Journal of clinical investigation, 页码：4342-4352 , 文章类型： Article，,卷期：2010年120-12] The circulating, adipocyte-secreted hormone adiponectin (APN) exerts protective effects on the heart under stress conditions The receptors binding APN to cardiac tissue, however, have remained elusive Here, we report tha... Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome-associated Sos1 mutation [作者：Chen, PC; Wakimoto, H; Conner, D; Araki, T; Yuan, T; Roberts, A; Seidman, CE; Bronson, R; Neel, BG; Seidman, JG; Kucherlapati, R,期刊：Journal of clinical investigation, 页码：4353-4365 , 文章类型： Article，,卷期：2010年120-12] Noonan syndrome (NS) is an autosomal dominant genetic disorder characterized by short stature, unique facial features, and congenital heart disease About 10%-15% of individuals with NS have mutations in son of sevenle... Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice [作者：Han, R; Frett, EM; Levy, JR; Rader, EP; Lueck, JD; Bansal, D; Moore, SA; Ng, R; de Bernabe, DBV; Faulkner, JA; Campbelll, KP,期刊：Journal of clinical investigation, 页码：4366-4374 , 文章类型： Article，,卷期：2010年120-12] Mutations in the dysferlin gene underlie a group of autosomal recessive muscle-wasting disorders denoted as dysferlinopathies Dysferlin has been shown to play roles in muscle membrane repair and muscle regeneration, both... Role of chronic ryanodine receptor phosphorylation in heart failure and beta-adrenergic receptor blockade in mice [作者：Shan, J; Betzenhauser, MJ; Kushnir, A; Reiken, S; Meli, AC; Wronska, A; Dura, M; Chen, BX; Marks, AR,期刊：Journal of clinical investigation, 页码：4375-4387 , 文章类型： Article，,卷期：2010年120-12] Increased sarcoplasmic reticulum (SR) Ca2+ leak via the cardiac ryanodine receptor/calcium release channel (RyR2) is thought to play a role in heart failure (HF) progression Inhibition of this leak is an emerging therape... Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice [作者：Shan, J; Kushnir, A; Betzenhauser, MJ; Reiken, S; Li, JD; Lehnart, SE; Lindegger, N; Mongillo, M; Mohler, PJ; Marks, AR,期刊：Journal of clinical investigation, 页码：4388-4398 , 文章类型： Article，,卷期：2010年120-12] During the classic "fight-or-flight" stress response, sympathetic nervous system activation leads to catecholamine release, which increases heart rate and contractility, resulting in enhanced cardiac output Catecholamine... Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2 [作者：Saslowsky, DE; Cho, JA; Chinnapen, H; Massol, RH; Chinnapen, DJF; Wagner, JS; De Luca, HE; Kam, W; Paw, BH; Lencer, WI,期刊：Journal of clinical investigation, 页码：4399-4409 , 文章类型： Article，,卷期：2010年120-12] Cholera toxin (CT) causes the massive secretory diarrhea associated with epidemic cholera To induce disease, CT enters the cytosol of host cells by co-opting a lipid-based sorting pathway from the plasma membrane, throug...