- QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids
[作者:Bringmann, G; Bischof, SK; Muller, S; Gulder, T; Winter, C; Stich, A; Moll, H; Kaiser, M; Brun, R; Dreher, J; Baumann, K,期刊:European Journal of Medicinal Chemistry, 页码:5370-5383 , 文章类型: Article,,卷期:2010年45-11]
- Naphthylisoquinoline alkaloids have attracted considerable interest because of their intriguing structure, their unique biosynthetic origin, and their biological activities against several pathogens causing tropical dise...
- Synthesis and biological evaluation of 2-phenylthiazole-4-carboxamide derivatives as anticancer agents
[作者:Aliabadi, A; Shamsa, F; Ostad, SN; Emami, S; Shafiee, A; Davoodi, J; Foroumadi, A,期刊:European Journal of Medicinal Chemistry, 页码:5384-5389 , 文章类型: Article,,卷期:2010年45-11]
- A series of substituted 2-phenylthiazole-4-carboxamide derivatives were synthesized as potential cytotoxic agents and evaluated against three human cancer cell lines including T47D (Breast cancer), Caco-2 (Colorectal can...
- 4-Aminoquinoline derived antimalarials: Synthesis, antiplasmodial activity and heme polymerization inhibition studies
[作者:Solomon, VR; Haq, W; Smilkstein, M; Srivastava, K; Puri, SK; Katti, SB,期刊:European Journal of Medicinal Chemistry, 页码:4990-4996 , 文章类型: Article,,卷期:2010年45-11]
- A new series of 4-aminoquinoline derivatives have been synthesized and found to be active against both susceptible and resistant strains of Plasmodium falciparum in vitro. Compound 1-[3-(7-chloro-quinolin-4-ylamino)-prop...
- Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery
[作者:Jain, S; Kaur, A; Puri, R; Utreja, P; Jain, A; Bhide, M; Ratnam, R; Singh, V; Patil, AS; Jayaraman, N; Kaushik, G; Yadav, S; Khanduja, KL,期刊:European Journal of Medicinal Chemistry, 页码:4997-5005 , 文章类型: Article,,卷期:2010年45-11]
- In the present study, an attempt was made to study the acute and sub-acute toxicity profile of G3-COOH Poly (propyl ether imine) [PETIM] dendrimer and its use as a carrier for sustained delivery of model drug ketoprofen....
- Synthesis, antimicrobial and anti-inflammatory activities of novel 5-(1-adamantyl)-1,3,4-thiadiazole derivatives
[作者:Kadi, AA; Al-Abdullah, ES; Shehata, IA; Habib, EE; Ibrahim, TM; El-Emam, AA,期刊:European Journal of Medicinal Chemistry, 页码:5006-5011 , 文章类型: Article,,卷期:2010年45-11]
- New 1-adamanyl-1,3,4-thiadiazole derivatives namely, 5-(1-adamantyl)-1,3,4-thiadiazoline-2-thione 3, 5-(1-adamantyl)-3-(benzyl- or 4-substituted benzyl)-1,3,4-thiadiazoline-2-thione 4a-d, 5-(1-adamantyl)-3-(4-substituted...
- New octahydroquinazoline derivatives: Synthesis and hypotensive activity
[作者:El-Sabbagh, OI; Shabaan, MA; Kadry, HH; Al-Din, ES,期刊:European Journal of Medicinal Chemistry, 页码:5390-5396 , 文章类型: Article,,卷期:2010年45-11]
- Several novel 1-(4-chlorophenyl)-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydro-5-oxo-3-(substitutedphenyl) quinazoline derivatives (2-21) structurally similar to prazosin, were prepared using Mannich reaction of 3-(4-chlorophen...
- Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety
[作者:Havrylyuk, D; Mosula, L; Zimenkovsky, B; Vasylenko, O; Gzella, A; Lesyk, R,期刊:European Journal of Medicinal Chemistry, 页码:5012-5021 , 文章类型: Article,,卷期:2010年45-11]
- Antitumor screening of several novel 4-thiazolidinones with benzothiazole moiety has been performed. Reactions of (benzothiazole-2-yl)hydrazine with trithiocarbonyl diglycolic acid or 6-methyl-2-amino-benzothiazole with ...
- Design and synthesis of bioactive adamantanaminoalcohols and adamantanamines
[作者:Zoidis, G; Kolocouris, N; Kelly, JM; Prathalingam, SR; Naesens, L; De Clercq, E,期刊:European Journal of Medicinal Chemistry, 页码:5022-5030 , 文章类型: Article,,卷期:2010年45-11]
- Adamantanamines 16, 18, 21, 24, 27, 28, 30, 32, 35, 36, 37, 40, 46 and 48 were synthesized and tested for anti-influenza A virus and trypanocidal activity. The stereoelectronic requirements for optimal antiviral and tryp...
- Pharmacophore modeling and virtual screening studies for new VEGFR-2 kinase inhibitors
[作者:Lee, K; Jeong, KW; Lee, Y; Song, JY; Kim, MS; Lee, GS; Kim, Y,期刊:European Journal of Medicinal Chemistry, 页码:5420-5427 , 文章类型: Article,,卷期:2010年45-11]
- Virtual screening was performed to determine potent vascular endothelial growth factor receptor (VEGFR)-2 kinase inhibitors. A database of approximately 820,000 commercial compounds was used for screening, and 100 compou...
- Synthesis and biological activities of new furo[3,4-b]carbazoles: Potential topoisomerase II inhibitors
[作者:Hajbi, Y; Neagoie, C; Biannic, B; Chilloux, A; Vedrenne, E; Baldeyrou, B; Bailly, C; Merour, JY; Rosca, S; Routier, S; Lansiaux, A,期刊:European Journal of Medicinal Chemistry, 页码:5428-5437 , 文章类型: Article,,卷期:2010年45-11]
- New 1,5-Dihydro-4-(substituted phenyl)-3H-furo[3,4-b]carbazol-3-ones were synthesised via a key step Diels-Alder reaction under microwave irradiation. 3-Formylindole was successfully used in a 6-step synthesis to obtain ...
- In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model
[作者:Raman, N; Jeyamurugan, R; Senthilkumar, R; Rajkapoor, B; Franzblau, SG,期刊:European Journal of Medicinal Chemistry, 页码:5438-5451 , 文章类型: Article,,卷期:2010年45-11]
- A new series of copper(II) and zinc(II) complexes have been designed and synthesized using a new type of Schiff bases derived from the reaction of 3-(3-phenyl-allylidene)-pentane-2,4-dione with para substituted aniline a...
- Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent
[作者:Kidwai, M; Poddar, R; Bhardwaj, S; Singh, S; Luthra, PM,期刊:European Journal of Medicinal Chemistry, 页码:5031-5038 , 文章类型: Article,,卷期:2010年45-11]
- Multi-component reaction (MCR) involves coupling of p-bromophenol with 2-Benzothiazolethiol, malononitrile and substituted aldehydes in aqueous K2CO3 as green base to synthesize 2-amino-6-benzothiazol-2-ylsulfanyl-chrome...
- Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition
[作者:Vantikommu, J; Palle, S; Reddy, PS; Ramanatham, V; Khagga, M; Pallapothula, VR,期刊:European Journal of Medicinal Chemistry, 页码:5044-5050 , 文章类型: Article,,卷期:2010年45-11]
- A facile and highly efficient method for the regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles (beta-keto 1,2,3-triazoles) in good to excellent yields from in-situ generated beta-ketoazides and terminal alkyn...
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