- In Vitro Characterization of T-Type Calcium Channel Antagonist TTA-A2 and In Vivo Effects on Arousal in Mice
[作者:Kraus, RL; Li, YX; Gregan, Y; Gotter, AL; Uebele, VN; Fox, SV; Doran, SM; Barrow, JC; Yang, ZQ; Reger, TS; Koblan, KS; Renger, JJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:409-417 , 文章类型: Article,,卷期:2010年335-2]
- T-type calcium channels have been implicated in many behaviorally important neurophysiological processes, and altered channel activity has been linked to the pathophysiology of neurological disorders such as insomnia, ep...
- Influence of a Time-Restricted Feeding Schedule on the Daily Rhythm of abcb1a Gene Expression and Its Function in Rat Intestine
[作者:Hayashi, Y; Ushijima, K; Ando, H; Yanagihara, H; Ishikawa, E; Tsuruoka, S; Sugimoto, K; Fujimura, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:418-423 , 文章类型: Article,,卷期:2010年335-2]
- P-glycoprotein (P-gp) is one of the ATP-binding cassette transporters and acts as an efflux pump for cytotoxic substances. P-gp mRNA expression and transporting activity show the daily rhythm and contribute to the chrono...
- The Blockade of Adenosine Deaminase Ameliorates Chronic Experimental Colitis through the Recruitment of Adenosine A(2A) and A(3) Receptors
[作者:Antonioli, L; Fornai, M; Colucci, R; Awwad, O; Ghisu, N; Tuccori, M; Da Settimo, F; La Motta, C; Natale, G; Duranti, E; Virdis, A; Blandizzi, C,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:434-442 , 文章类型: Article,,卷期:2010年335-2]
- Adenosine modulates immune/inflammatory reactions. This study investigates the expression of adenosine deaminase in the inflamed colon, the effects of adenosine deaminase inhibitors on established colitis, and the recrui...
- Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O-2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as Safe Anti-Inflammatory, Analgesic, Antipyretic, Antioxidant Prodrugs
[作者:Chattopadhyay, M; Velazquez, CA; Pruski, A; Nia, KV; Abdellatif, KR; Keefer, LK; Kashfi, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:443-450 , 文章类型: Article,,卷期:2010年335-2]
- Chronic inflammation is an underlying etiological factor in carcinogenesis; nonsteroidal anti-inflammatory drugs (NSAIDs) and their chemically modified NO-releasing prodrugs (NO-NSAIDs) are promising chemopreventive agen...
- Increased Blood Pressure and Hyperdynamic Cardiovascular Responses in Carriers of a Common Hyperfunctional Variant of Adenylyl Cyclase 6
[作者:Hodges, GJ; Gros, R; Hegele, RA; Van Uum, S; Shoemaker, JK; Feldman, RD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:451-457 , 文章类型: Article,,卷期:2010年335-2]
- Adenylyl cyclase (ADCY) is a critical regulator of metabolic and cardiovascular function. We have identified a genetic variant (A674S) in ADCY isoform 6 (ADCY6). Subsequent studies demonstrated that the expression of thi...
- Estrogen Receptor Expression Is Required for Low-Dose Resveratrol-Mediated Repression of Aryl Hydrocarbon Receptor Activity
[作者:Perdew, GH; Hollingshead, BD; DiNatale, BC; Morales, JL; Labrecque, MP; Takhar, MK; Tam, KJ; Beischlag, TV,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:273-283 , 文章类型: Article,,卷期:2010年335-2]
- The putative cardioprotective and chemopreventive properties of the red wine phenolic resveratrol (RES) have made it the subject of a growing body of clinical and basic research. We have begun investigations focusing on ...
- Novel Radioiodinated gamma-Hydroxybutyric Acid Analogues for Radiolabeling and Photolinking of High-Affinity gamma-Hydroxybutyric Acid Binding Sites
[作者:Wellendorph, P; Hog, S; Sabbatini, P; Pedersen, MHF; Martiny, L; Knudsen, GM; Frolund, B; Clausen, RP; Brauner-Osborne, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:458-464 , 文章类型: Article,,卷期:2010年335-2]
- gamma-Hydroxybutyric acid (GHB) is a therapeutic drug, a drug of abuse, and an endogenous substance that binds to low-and high-affinity sites in the mammalian brain. To target the specific GHB binding sites, we have deve...
- The D Prostanoid Receptor Agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] Inhibits Fibroblast Proliferation and Bleomycin-Induced Lung Fibrosis in Mice
[作者:van den Brule, S; Wallemme, L; Uwambayinema, F; Huaux, F; Lison, D,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:472-479 , 文章类型: Article,,卷期:2010年335-2]
- Prostaglandin (PG) D-2 exerts contrasting activities in the inflamed lung via two receptors, the D prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on T helper 2 lymphocytes. DP act...
- The Residual Nonadrenergic Contractile Response to Nerve Stimulation of the Mouse Prostate Is Mediated by Acetylcholine but Not ATP in a Comparison with the Mouse Vas Deferens
[作者:White, CW; Short, JL; Haynes, JM; Evans, RJ; Ventura, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:489-496 , 文章类型: Article,,卷期:2010年335-2]
- Neuronal release of noradrenaline is primarily responsible for the contraction of prostatic smooth muscle in all species, and this forms the basis for the use of alpha(1)-adrenoceptor antagonists as pharmacotherapies for...
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