- Inhibition of brain tumor growth by intravenous poly (beta-L-malic acid) nanobioconjugate with pH-dependent drug release
[作者:Ding, H; Inoue, S; Ljubimov, AV; Patil, R; Portilla-Arias, J; Hu, JW; Konda, B; Wawrowsky, KA; Fujita, M; Karabalin, N; Sasakie, T; Black, KL; Holler, E; Ljubimova, JY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18143-18148 , 文章类型: Article,,卷期:2010年107-42]
- Effective treatment of brain neurological disorders such as Alzheimer's disease, multiple sclerosis, or tumors should be possible with drug delivery through blood-brain barrier (BBB) or blood-brain tumor barrier (BTB) an...
- Elicitation of structure-specific antibodies by epitope scaffolds
[作者:Ofek, G; Guenaga, FJ; Schief, WR; Skinner, J; Baker, D; Wyatt, R; Kwong, PD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17880-17887 , 文章类型: Article,,卷期:2010年107-42]
- Elicitation of antibodies against targets that are immunorecessive, cryptic, or transient in their native context has been a challenge for vaccine design. Here we demonstrate the elicitation of structure-specific antibod...
- Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep
[作者:Funato, H; Sato, M; Sinton, CM; Gautron, L; Williams, SC; Skach, A; Elmquist, JK; Skoultchi, AI; Yanagisawa, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18155-18160 , 文章类型: Article,,卷期:2010年107-42]
- Sleep and wakefulness are regulated primarily by inhibitory interactions between the hypothalamus and brainstem. The expression of the states of rapid eye movement (REM) sleep and non-REM (NREM) sleep also are correlated...
- Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome
[作者:Wu, H; Tao, JF; Chen, PJ; Shahab, A; Ge, WH; Hart, RP; Ruan, XA; Ruan, YJ; Sun, YE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18161-18166 , 文章类型: Article,,卷期:2010年107-42]
- MicroRNAs (miRNAs) are a class of small, noncoding RNAs that function as posttranscriptional regulators of gene expression. Many miRNAs are expressed in the developing brain and regulate multiple aspects of neural develo...
- Controlling the growth and shape of chiral supramolecular polymers in water
[作者:Besenius, P; Portale, G; Bomans, PHH; Janssen, HM; Palmans, ARA; Meijer, EW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17888-17893 , 文章类型: Article,,卷期:2010年107-42]
- A challenging target in the noncovalent synthesis of nanostructured functional materials is the formation of uniform features that exhibit well-defined properties, e. g., precise control over the aggregate shape, size, a...
- Injectable hydrogel microbeads for fluorescence-based in vivo continuous glucose monitoring
[作者:Shibata, H; Heo, YJ; Okitsu, T; Matsunaga, Y; Kawanishi, T; Takeuchi, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17894-17898 , 文章类型: Article,,卷期:2010年107-42]
- Fluorescent microbeads hold great promise for in vivo continuous glucose monitoring with wireless transdermal transmission and long-lasting activity. The full potential of fluorescent microbeads has yet to be realized du...
- Arc regulates spine morphology and maintains network stability in vivo
[作者:Peebles, CL; Yoo, J; Thwin, MT; Palop, JJ; Noebels, JL; Finkbeiner, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18173-18178 , 文章类型: Article,,卷期:2010年107-42]
- Long-term memory relies on modulation of synaptic connections in response to experience. This plasticity involves trafficking of AMPA receptors (AMPAR) and alteration of spine morphology. Arc, a gene induced by synaptic ...
- Asian dust particles converted into aqueous droplets under remote marine atmospheric conditions
[作者:Tobo, Y; Zhang, DZ; Matsuki, A; Iwasaka, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17905-17910 , 文章类型: Article,,卷期:2010年107-42]
- The chemical history of dust particles in the atmosphere is crucial for assessing their impact on both the Earth's climate and ecosystem. So far, a number of studies have shown that, in the vicinity of strong anthropogen...
- Devonian rise in atmospheric oxygen correlated to the radiations of terrestrial plants and large predatory fish
[作者:Dahl, TW; Hammarlund, EU; Anbar, AD; Bond, DPG; Gill, BC; Gordon, GW; Knoll, AH; Nielsen, AT; Schovsbo, NH; Canfield, DE,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17911-17915 , 文章类型: Article,,卷期:2010年107-42]
- The evolution of Earth's biota is intimately linked to the oxygenation of the oceans and atmosphere. We use the isotopic composition and concentration of molybdenum (Mo) in sedimentary rocks to explore this relationship....
- Satellite-based global-ocean mass balance estimates of interannual variability and emerging trends in continental freshwater discharge
[作者:Syed, TH; Famiglietti, JS; Chambers, DP; Willis, JK; Hilburn, K,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:17916-17921 , 文章类型: Article,,卷期:2010年107-42]
- Freshwater discharge from the continents is a key component of Earth's water cycle that sustains human life and ecosystem health. Surprisingly, owing to a number of socioeconomic and political obstacles, a comprehensive ...
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