- Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction
[作者:Li, YY; Stewart, NK; Berger, AJ; Vos, S; Schoeffler, AJ; Berger, JM; Chait, BT; Oakley, MG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18832-18837 , 文章类型: Article,,卷期:2010年107-44]
- In contrast to the current state of knowledge in the field of eukaryotic chromosome segregation, relatively little is known about the mechanisms coordinating the appropriate segregation of bacterial chromosomes. In Esche...
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
[作者:McMahon, M; Lamont, DJ; Beattie, KA; Hayes, JD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18838-18843 , 文章类型: Article,,卷期:2010年107-44]
- Recognition and repair of cellular damage is crucial if organisms are to survive harmful environmental conditions. In mammals, the Keap1 protein orchestrates this response, but how it perceives adverse circumstances is n...
- Single-particle cryoelectron microscopy analysis reveals the HIV-1 spike as a tripod structure
[作者:Wu, SR; Loving, R; Lindqvist, B; Hebert, H; Koeck, PJB; Sjoberg, M; Garoff, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18844-18849 , 文章类型: Article,,卷期:2010年107-44]
- The HIV-1 spike is a trimer of the transmembrane gp41 and the peripheral gp120 subunit pair. It is activated for virus-cell membrane fusion by binding sequentially to CD4 and to a chemokine receptor. Here we have studied...
- Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation
[作者:Anderson, VL; Ramlall, TF; Rospigliosi, CC; Webb, WW; Eliezer, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18850-18855 , 文章类型: Article,,卷期:2010年107-44]
- Because oligomers and aggregates of the protein alpha-synuclein (alpha S) are implicated in the initiation and progression of Parkinson's disease, investigation of various alpha S aggregation pathways and intermediates a...
- Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes
[作者:Colombo, SL; Palacios-Callender, M; Frakich, N; De Leon, J; Schmitt, CA; Boorn, L; Davis, N; Moncada, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18868-18873 , 文章类型: Article,,卷期:2010年107-44]
- Cell proliferation is accompanied by an increase in the utilization of glucose and glutamine. The proliferative response is dependent on a decrease in the activity of the ubiquitin ligase anaphase-promoting complex/cyclo...
- Mullerian inhibiting substance preferentially inhibits stem/progenitors in human ovarian cancer cell lines compared with chemotherapeutics
[作者:Wei, XL; Dombkowski, D; Meirelles, K; Pieretti-Vanmarcke, R; Szotek, PP; Chang, HL; Preffer, FI; Mueller, PR; Teixeira, J; MacLaughlin, DT; Donahoe, PK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18874-18879 , 文章类型: Article,,卷期:2010年107-44]
- Cancer stem cells are proposed to be tumor-initiating cells capable of tumorigenesis, recurrence, metastasis, and drug resistance, and, like somatic stem cells, are thought to be capable of unlimited self-renewal and, wh...
- Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema
[作者:Chen, ZH; Lam, HC; Jin, Y; Kim, HP; Cao, JF; Lee, SJ; Ifedigbo, E; Parameswaran, H; Ryter, SW; Choi, AMK,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18880-18885 , 文章类型: Article,,卷期:2010年107-44]
Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by chronic exposure to cigarette smoke (CS), which involves airway obstruction and alveolar loss (i.e., emphysema). The mechanisms of COPD ...
- Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1
[作者:Sheng, NY; Xie, ZH; Wang, C; Bai, G; Zhang, KJ; Zhu, QQ; Song, JG; Guillemot, F; Chen, YG; Lin, AN; Jing, NH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18886-18891 , 文章类型: Article,,卷期:2010年107-44]
- The proper function of the bone morphogenic protein (BMP) pathway during embryonic development and organ maintenance requires its communication with other signaling pathways. Unlike the well-documented regulation of the ...
- LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling
[作者:Gao, YJ; Xiao, QA; Ma, HM; Li, L; Liu, J; Feng, Y; Fang, ZY; Wu, J; Han, XK; Zhang, JH; Sun, YH; Wu, GW; Padera, R; Chen, HQ; Wong, KK; Ge, GX; Ji, HB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18892-18897 , 文章类型: Article,,卷期:2010年107-44]
- LKB1 loss-of-function mutations, observed in similar to 30% of human lung adenocarcinomas, contribute significantly to lung cancer malignancy progression. We show that lysyl oxidase ( LOX), negatively regulated by LKB1 t...
- Skeletal development in sloths and the evolution of mammalian vertebral patterning
[作者:Hautier, L; Weisbecker, V; Sanchez-Villagra, MR; Goswami, A; Asher, RJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:18903-18908 , 文章类型: Article,,卷期:2010年107-44]
- Mammals show a very low level of variation in vertebral count, particularly in the neck. Phenotypes exhibited at various stages during the development of the axial skeleton may play a key role in testing mechanisms recen...
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