- Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides inhibit tumor development in a mouse model of ovarian cancer
[作者:Su, F; Kozak, KR; Imaizumi, S; Gao, F; Amneus, MW; Grijalva, V; Ng, C; Wagner, A; Hough, G; Farias-Eisner, G; Anantharamaiah, GM; Van Lenten, BJ; Navab, M; Fogelman, AM; Reddy, ST; Farias-Eisner, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19997-20002 , 文章类型: Article,,卷期:2010年107-46]
- We examined whether reduced levels of Apolipoprotein A-I (apoAI) in ovarian cancer patients are causal in ovarian cancer in a mouse model. Mice expressing a human apoA-I transgene had (i) increased survival (P < 0.0001) ...
- Filament structure of bacterial tubulin homologue TubZ
[作者:Aylett, CHS; Wang, Q; Michie, KA; Amos, LA; Lowe, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19766-19771 , 文章类型: Article,,卷期:2010年107-46]
- Low copy number plasmids often depend on accurate partitioning systems for their continued survival. Generally, such systems consist of a centromere-like region of DNA, a DNA-binding adaptor, and a polymerizing cytomotiv...
- Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition
[作者:Kim, S; Sun, HB; Ball, HL; Wassmann, K; Luo, XL; Yu, HT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19772-19777 , 文章类型: Article,,卷期:2010年107-46]
- Regulated conformational changes of proteins are critical for cellular signal transduction. The spindle checkpoint protein Mad2 is an unusual protein with two native folds: the latent open conformer (O-Mad2) and the acti...
- Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa
[作者:Morita, H; Wanibuchi, K; Nii, H; Kato, R; Sugio, S; Abe, I,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19778-19783 , 文章类型: Article,,卷期:2010年107-46]
- Curcuminoid synthase (CUS) from Oryza sativa is a plant-specific type III polyketide synthase (PKS) that catalyzes the remarkable one-pot formation of the C-6-C-7-C-6 diarylheptanoid scaffold of bisdemethoxycurcumin, by ...
- Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts
[作者:Kojima, Y; Acar, A; Eaton, EN; Mellody, KT; Scheel, C; Ben-Porath, I; Onder, TT; Wang, ZC; Richardson, AL; Weinberg, RA; Orimo, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20009-20014 , 文章类型: Article,,卷期:2010年107-46]
- Much interest is currently focused on the emerging role of tumor-stroma interactions essential for supporting tumor progression. Carcinoma-associated fibroblasts (CAFs), frequently present in the stroma of human breast c...
- Mechanism of ligand-gated potassium efflux in bacterial pathogens
[作者:Roosild, TP; Castronovo, S; Healy, J; Miller, S; Pliotas, C; Rasmussen, T; Bartlett, W; Conway, SJ; Booth, IR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19784-19789 , 文章类型: Article,,卷期:2010年107-46]
- Gram negative pathogens are protected against toxic electrophilic compounds by glutathione-gated potassium efflux systems (Kef) that modulate cytoplasmic pH. We have elucidated the mechanism of gating through structural ...
- Emergence of resting state networks in the preterm human brain
[作者:Doria, V; Beckmann, CF; Arichi, T; Merchant, N; Groppo, M; Turkheimer, FE; Counsell, SJ; Murgasova, M; Aljabar, P; Nunes, RG; Larkman, DJ; Rees, G; Edwards, AD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20015-20020 , 文章类型: Article,,卷期:2010年107-46]
- The functions of the resting state networks (RSNs) revealed by functional MRI remain unclear, but it has seemed possible that networks emerge in parallel with the development of related cognitive functions. We tested the...
- Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics
[作者:Candolfi, M; Xiong, WD; Yagiz, K; Liu, CY; Muhammad, AKMG; Puntel, M; Foulad, D; Zadmehr, A; Ahlzadeh, GE; Kroeger, KM; Tesarfreund, M; Lee, S; Debinski, W; Sareen, D; Svendsend, CN; Rodriguez, R; Lowenstein, PR; Castro, MG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20021-20026 , 文章类型: Article,,卷期:2010年107-46]
- Restricting the cytotoxicity of anticancer agents by targeting receptors exclusively expressed on tumor cells is critical when treating infiltrative brain tumors such as glioblastoma multiforme (GBM). GBMs express an IL-...
- Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP
[作者:Khan, MQ; Sweeting, B; Mulligan, VK; Arslan, PE; Cashman, NR; Pai, EF; Chakrabartty, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:19808-19813 , 文章类型: Article,,卷期:2010年107-46]
- Prion diseases occur when the normally alpha-helical prion protein (PrP) converts to a pathological beta-structured state with prion infectivity (PrPSc). Exposure to PrPSc from other mammals can catalyze this conversion....
- Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis
[作者:Qiu, W; Wang, XW; Leibowitz, B; Liu, HT; Barker, N; Okada, H; Oue, N; Yasui, W; Clevers, H; Schoen, RE; Yu, JA; Zhang, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20027-20032 , 文章类型: Article,,卷期:2010年107-46]
- Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac effectively prevent colon cancer in humans and rodent models. However, their cellular targets and underlying mechanisms have remained elusive. We found that ...
- Spliced leader-based metatranscriptomic analyses lead to recognition of hidden genomic features in dinoflagellates
[作者:Lin, SJ; Zhang, HA; Zhuang, YY; Tran, B; Gill, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20033-20038 , 文章类型: Article,,卷期:2010年107-46]
- Environmental transcriptomics (metatranscriptomics) for a specific lineage of eukaryotic microbes (e. g., Dinoflagellata) would be instrumental for unraveling the genetic mechanisms by which these microbes respond to the...
|