- Trapping of palindromic ligands within native transthyretin prevents amyloid formation
[作者:Kolstoe, SE; Mangione, PP; Bellotti, V; Taylor, GW; Tennent, GA; Deroo, S; Morrison, AJ; Cobb, AJA; Coyne, A; McCammon, MG; Warner, TD; Mitchell, J; Gill, R; Smith, MD; Ley, SV; Robinson, CV; Wood, SP; Pepys, MB,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20483-20488 , 文章类型: Article,,卷期:2010年107-47]
- Transthyretin (TTR) amyloidosis is a fatal disease for which new therapeutic approaches are urgently needed. We have designed two palindromic ligands, 2,2'-(4,4'-(heptane-1,7-diylbis(oxy))bis (3,5-dichloro-4,1-phenylene)...
- Robust crop resistance to broadleaf and grass herbicides provided by aryloxyalkanoate dioxygenase transgenes
[作者:Wright, TR; Shan, GM; Walsh, TA; Lira, JM; Cui, C; Song, P; Zhuang, MB; Arnold, NL; Lin, GF; Yau, K; Russell, SM; Cicchillo, RM; Peterson, MA; Simpson, DM; Zhou, N; Ponsamuel, J; Zhang, ZY,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20240-20245 , 文章类型: Article,,卷期:2010年107-47]
- Engineered glyphosate resistance is the most widely adopted genetically modified trait in agriculture, gaining widespread acceptance by providing a simple robust weed control system. However, extensive and sustained use ...
- pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation
[作者:An, M; Wijesinghe, D; Andreev, OA; Reshetnyak, YK; Engelman, DM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20246-20250 , 文章类型: Article,,卷期:2010年107-47]
- We find that pH-(low)-insertion-peptide (pHLIP)-facilitated translocation of phalloidin, a cell-impermeable polar toxin, inhibits the proliferation of cancer cells in a pH-dependent fashion. The monomeric pHLIP inserts i...
- Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis
[作者:Gisselsson, D; Jin, YS; Lindgren, D; Persson, J; Gisselsson, L; Hanks, S; Sehic, D; Mengelbier, LH; Ora, I; Rahman, N; Mertens, F; Mitelman, F; Mandahl, N,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20489-20493 , 文章类型: Article,,卷期:2010年107-47]
- One extra chromosome copy (i.e., trisomy) is the most common type of chromosome aberration in cancer cells. The mechanisms behind the generation of trisomies in tumor cells are largely unknown, although it has been sugge...
- RNA polymerase mutants found through adaptive evolution reprogram Escherichia coli for optimal growth in minimal media
[作者:Conrad, TM; Frazier, M; Joyce, AR; Cho, BK; Knight, EM; Lewis, NE; Landick, R; Palsson, BO,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20500-20505 , 文章类型: Article,,卷期:2010年107-47]
- Specific small deletions within the rpoC gene encoding the beta'-subunit of RNA polymerase (RNAP) are found repeatedly after adaptation of Escherichia coli K-12 MG1655 to growth in minimal media. Here we present a multis...
- Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents
[作者:Geyer, BC; Kannan, L; Garnaud, PE; Broomfield, CA; Cadieux, CL; Cherni, I; Hodgins, SM; Kasten, SA; Kelley, K; Kilbourne, J; Oliver, ZP; Otto, TC; Puffenberger, I; Reeves, TE; Robbins, N; Woods, RR; Soreq, H; Lenz, DE; Cerasoli, DM; Mor, TS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20251-20256 , 文章类型: Article,,卷期:2010年107-47]
- The concept of using cholinesterase bioscavengers for prophylaxis against organophosphorous nerve agents and pesticides has progressed from the bench to clinical trial. However, the supply of the native human proteins is...
- Salmonella pathogenicity island 2 expression negatively controlled by EIIA(Ntr)-SsrB interaction is required for Salmonella virulence
[作者:Choi, J; Shin, D; Yoon, H; Kim, J; Lee, CR; Kim, M; Seok, YJ; Ryu, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20506-20511 , 文章类型: Article,,卷期:2010年107-47]
- SsrA/SsrB is a primary two-component system that mediates the survival and replication of Salmonella within host cells. When activated, the SsrB response regulator directly promotes the transcription of multiple genes wi...
- Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline
[作者:Terrando, N; Monaco, C; Ma, DQ; Foxwell, BMJ; Feldmann, M; Maze, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20518-20522 , 文章类型: Article,,卷期:2010年107-47]
- Cognitive decline following surgery in older individuals is a major clinical problem of uncertain mechanism; a similar cognitive decline also follows severe infection, chemotherapy, or trauma and is currently without eff...
- Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone
[作者:Kolonko, EM; Albaugh, BN; Lindner, SE; Chen, YY; Satyshur, KA; Arnold, KM; Kaufman, PD; Keck, JL; Denu, JM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20275-20280 , 文章类型: Article,,卷期:2010年107-47]
- Most histone acetyltransferases (HATs) function as multisubunit complexes in which accessory proteins regulate substrate specificity and catalytic efficiency. Rtt109 is a particularly interesting example of a HAT whose s...
- Deficits in axonal transport precede ALS symptoms in vivo
[作者:Bilsland, LG; Sahai, E; Kelly, G; Golding, M; Greensmith, L; Schiavo, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20523-20528 , 文章类型: Article,,卷期:2010年107-47]
- ALS is a fatal neurodegenerative disease characterized by selective motor neuron death resulting in muscle paralysis. Mutations in superoxide dismutase 1 (SOD1) are responsible for a subset of familial cases of ALS. Alth...
- Pleasurable behaviors reduce stress via brain reward pathways
[作者:Ulrich-Lai, YM; Christiansen, AM; Ostrander, MM; Jones, AA; Jones, KR; Choi, DC; Krause, EG; Evanson, NK; Furay, AR; Davis, JF; Solomon, MB; de Kloet, AD; Tamashiro, KL; Sakai, RR; Seeley, RJ; Woods, SC; Herman, JP,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20529-20534 , 文章类型: Article,,卷期:2010年107-47]
- Individuals often eat calorically dense, highly palatable "comfort" foods during stress for stress relief. This article demonstrates that palatable food intake (limited intake of sucrose drink) reduces neuroendocrine, ca...
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