- An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis
[作者:Quintana, FJ; Murugaiyan, G; Farez, MF; Mitsdoerffer, M; Tukpah, AM; Burns, EJ; Weiner, HL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20768-20773 , 文章类型: Article,,卷期:2010年107-48]
- The ligand-activated transcription factor aryl hydrocarbon receptor (AHR) participates in the differentiation of FoxP3(+) T-reg, Tr1 cells, and IL-17-producing T cells (Th17). Most of our understanding on the role of AHR...
- Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi
[作者:Chen, JM; Xie, CC; Tian, LL; Hong, LX; Wu, XR; Han, JH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20774-20779 , 文章类型: Article,,卷期:2010年107-48]
- The signaling network of innate immunity in Drosophila is constructed by multiple evolutionarily conserved pathways, including the Toll- or Imd-regulated NF-kappa B and JNK pathways. The p38 MAPK pathway is evolutionaril...
- Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors
[作者:Hafner, C; Toll, A; Fernandez-Casado, A; Earl, J; Marques, M; Acquadro, F; Mendez-Pertuz, M; Urioste, M; Malats, N; Burns, JE; Knowles, MA; Cigudosa, JC; Hartmann, A; Vogt, T; Landthaler, M; Pujol, RM; Real, FX,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20780-20785 , 文章类型: Article,,卷期:2010年107-48]
- Malignant tumors result from the accumulation of genetic alterations in oncogenes and tumor suppressor genes. Much less is known about the genetic changes in benign tumors. Seborrheic keratoses (SK) are very frequent ben...
- Suppression of Rev3, the catalytic subunit of Pol zeta, sensitizes drug-resistant lung tumors to chemotherapy
[作者:Doles, J; Oliver, TG; Cameron, ER; Hsu, G; Jacks, T; Walker, GC; Hemann, MT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20786-20791 , 文章类型: Article,,卷期:2010年107-48]
- Platinum-based chemotherapeutic drugs are front-line therapies for the treatment of non-small cell lung cancer. However, intrinsic drug resistance limits the clinical efficacy of these agents. Recent evidence suggests th...
- HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication
[作者:Izumi, T; Io, K; Matsui, M; Shirakawa, K; Shinohara, M; Nagai, Y; Kawahara, M; Kobayashi, M; Kondoh, H; Misawa, N; Koyanagi, Y; Uchiyama, T; Takaori-Kondo, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20798-20803 , 文章类型: Article,,卷期:2010年107-48]
- Viral infectivity factor, an accessory protein encoded in the HIV-1 genome, induces G2 cell cycle arrest; however, the biological significance and mechanism(s) remain totally unclear. Here we demonstrate that the TP53 pa...
- Syntaxin clusters assemble reversibly at sites of secretory granules in live cells
[作者:Barg, S; Knowles, MK; Chen, X; Midorikawa, M; Almers, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20804-20809 , 文章类型: Article,,卷期:2010年107-48]
- Syntaxin resides in the plasma membrane, where it helps to catalyze membrane fusion during exocytosis. The protein also forms clusters in cell-free and granule-free plasma-membrane sheets. We imaged the interaction betwe...
- Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers
[作者:Knowles, MK; Barg, S; Wan, L; Midorikawa, M; Chen, X; Almers, W,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20810-20815 , 文章类型: Article,,卷期:2010年107-48]
- Before secretory vesicles undergo exocytosis, they must recruit the proteins syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in the plasma membrane. GFP-labeled versions of both proteins cluster at sites wher...
- Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits
[作者:Tamayev, R; Matsuda, S; Fa, M; Arancio, O; D'Adamio, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20822-20827 , 文章类型: Article,,卷期:2010年107-48]
- According to the prevailing "amyloid cascade hypothesis," genetic dementias such as Alzheimer's disease and familial Danish dementia (FDD) are caused by amyloid deposits that trigger tauopathy, neurodegeneration, and beh...
- Imbalance of ionic conductances contributes to diverse symptoms of demyelination
[作者:Coggan, JS; Prescott, SA; Bartol, TM; Sejnowski, TJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20602-20609 , 文章类型: Article,,卷期:2010年107-48]
- Fast axonal conduction of action potentials in mammals relies on myelin insulation. Demyelination can cause slowed, blocked, desynchronized, or paradoxically excessive spiking that underlies the symptoms observed in demy...
- miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor
[作者:Renthal, NE; Chen, CC; Williams, KC; Gerard, RD; Prange-Kiel, J; Mendelson, CR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20828-20833 , 文章类型: Article,,卷期:2010年107-48]
- Throughout most of pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) transcriptional activity, whereas spontaneous labor is initiated/facilitated by a concerted series of biochemical eve...
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