- NMDA receptors regulate GABA(A) receptor lateral mobility and clustering at inhibitory synapses through serine 327 on the gamma 2 subunit
[作者:Muir, J; Arancibia-Carcamo, IL; MacAskill, AF; Smith, KR; Griffin, LD; Kittler, JT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16679-16684 , 文章类型: Article,,卷期:2010年107-38]
- Modification of the number of GABA(A) receptors (GABA(A)Rs) clustered at inhibitory synapses can regulate inhibitory synapse strength with important implications for information processing and nervous system plasticity a...
- Corepressor for element-1-silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions
[作者:Abrajano, JJ; Qureshi, IA; Gokhan, S; Molero, AE; Zheng, DY; Bergman, A; Mehler, MF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16685-16690 , 文章类型: Article,,卷期:2010年107-38]
- The repressor element-1 (RE1) silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) silences neuronal genes in neural stem cells (NSCs) and nonneuronal cells through its role as a dynamic modular ...
- Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
[作者:Ko, HS; Lee, Y; Shin, JH; Karuppagounder, SS; Gadad, BS; Koleske, AJ; Pletnikova, O; Troncoso, JC; Dawson, VL; Dawson, TM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16691-16696 , 文章类型: Article,,卷期:2010年107-38]
- Mutations in PARK2/Parkin, which encodes a ubiquitin E3 ligase, cause autosomal recessive Parkinson disease (PD). Here we show that the nonreceptor tyrosine kinase c-Abl phosphorylates tyrosine 143 of parkin, inhibiting ...
- Hippocampal long-term depression is required for the consolidation of spatial memory
[作者:Ge, YA; Dong, ZF; Bagot, RC; Howland, JG; Phillips, AG; Wong, TP; Wang, YT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16697-16702 , 文章类型: Article,,卷期:2010年107-38]
- Although NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term depression (LTD) of glutamatergic transmission are candidate mechanisms for long-term spatial memory, the precise contributions of LTP a...
- Sharp rates of decay of solutions to the nonlinear fast diffusion equation via functional inequalities
[作者:Bonforte, M; Dolbeault, J; Grillo, G; Vazquez, JL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16459-16464 , 文章类型: Article,,卷期:2010年107-38]
- The goal of this paper is to state the optimal decay rate for solutions of the nonlinear fast diffusion equation and, in self-similar variables, the optimal convergence rates to Barenblatt self-similar profiles and their...
- Correction for hidden confounders in the genetic analysis of gene expression
[作者:Listgarten, J; Kadie, C; Schadt, EE; Heckerman, D,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16465-16470 , 文章类型: Article,,卷期:2010年107-38]
- Understanding the genetic underpinnings of disease is important for screening, treatment, drug development, and basic biological insight. One way of getting at such an understanding is to find out which parts of our DNA,...
- Physical interaction between VIVID and white collar complex regulates photoadaptation in Neurospora
[作者:Chen, CH; DeMay, BS; Gladfelter, AS; Dunlap, JC; Loros, JJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16715-16720 , 文章类型: Article,,卷期:2010年107-38]
- Photoadaptation, the ability to attenuate a light response on prolonged light exposure while remaining sensitive to escalating changes in light intensity, is essential for organisms to decipher time information appropria...
- Neural inhibition enables selection during language processing
[作者:Snyder, HR; Hutchison, N; Nyhus, E; Curran, T; Banich, MT; O'Reilly, RC; Munakata, Y,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16483-16488 , 文章类型: Article,,卷期:2010年107-38]
- Whether grocery shopping or choosing words to express a thought, selecting between options can be challenging, especially for people with anxiety. We investigate the neural mechanisms supporting selection during language...
- LIL3, a light-harvesting-like protein, plays an essential role in chlorophyll and tocopherol biosynthesis
[作者:Tanaka, R; Rothbart, M; Oka, S; Takabayashi, A; Takahashi, K; Shibata, M; Myouga, F; Motohashi, R; Shinozaki, K; Grimm, B; Tanaka, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16721-16725 , 文章类型: Article,,卷期:2010年107-38]
The light-harvesting chlorophyll-binding (LHC) proteins are major constituents of eukaryotic photosynthetic machinery. In plants, six different groups of proteins, LHC-like proteins, share a conserved motif with LHC. ...
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