- Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
[作者:Someya, S; Yu, W; Hallows, WC; Xu, JZ; Vann, JM; Leeuwenburgh, C; Tanokura, M; Denu, JM; Prolla, TA,期刊:Cell, 页码:802-812 , 文章类型: Article,,卷期:2010年143-5]
- Caloric restriction (CR) extends the life span and health span of a variety of species and slows the progression of age-related hearing loss (AHL), a common age-related disorder associated with oxidative stress. Here, we...
- Reelin and Stk25 Have Opposing Roles in Neuronal Polarization and Dendritic Golgi Deployment
[作者:Matsuki, T; Matthews, RT; Cooper, JA; van der Brug, MP; Cookson, MR; Hardy, JA; Olson, EC; Howell, BW,期刊:Cell, 页码:826-836 , 文章类型: Article,,卷期:2010年143-5]
- The Reelin ligand regulates a Dab1-dependent signaling pathway required for brain lamination and normal dendritogenesis, but the specific mechanisms underlying these actions remain unclear. We find that Stk25, a modifier...
- A Human Genome Structural Variation Sequencing Resource Reveals Insights into Mutational Mechanisms
[作者:Kidd, JM; Graves, T; Newman, TL; Fulton, R; Hayden, HS; Malig, M; Kallicki, J; Kaul, R; Wilson, RK; Eichler, EE,期刊:Cell, 页码:837-847 , 文章类型: Article,,卷期:2010年143-5]
- Understanding the prevailing mutational mechanisms responsible for human genome structural variation requires uniformity in the discovery of allelic variants and precision in terms of breakpoint delineation. We develop a...
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