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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共30条记录   A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemias [作者：Gruszka, AM; Lavorgna, S; Consalvo, MI; Ottone, T; Martinelli, C; Cinquanta, M; Ossolengo, G; Pruneri, G; Buccisano, F; Divona, M; Cedrone, M; Ammatuna, E; Venditti, A; de Marco, A; Lo-Coco, F; Pelicci, PG,期刊：Blood, 页码：2096-2102 , 文章类型： Article，,卷期：2010年116-12] Mutations in the nucleophosmin 1 (NPM1) gene are the most frequent genetic aberrations of acute myeloid leukemia (AML) and define a clinically distinct subset of AML. A monoclonal antibody (T26) was raised against a 19-a... Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice [作者：Agerstam, H; Jaras, M; Andersson, A; Johnels, P; Hansen, N; Lassen, C; Rissler, M; Gisselsson, D; Olofsson, T; Richter, J; Fan, XL; Ehinger, M; Fioretos, T,期刊：Blood, 页码：2103-2111 , 文章类型： Article，,卷期：2010年116-12] The 8p11 myeloproliferative syndrome (EMS), also referred to as stem cell leukemia/lymphoma, is a chronic myeloproliferative disorder that rapidly progresses into acute leukemia. Molecularly, EMS is characterized by fusi... Properties of CD34(+) CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate [作者：Jiang, XY; Forrest, D; Nicolini, F; Turhan, A; Guilhot, J; Yip, C; Holyoake, T; Jorgensen, H; Lambie, K; Saw, KM; Pang, E; Vukovic, R; Lehn, P; Ringrose, A; Yu, MA; Brinkman, RR; Smith, C; Eaves, A; Eaves, C,期刊：Blood, 页码：2112-2121 , 文章类型： Article，,卷期：2010年116-12] Imatinib mesylate (IM) induces clinical remissions in chronic-phase chronic myeloid leukemia (CML) patients but IM resistance remains a problem. We recently identified several features of CML CD34(+) stem/progenitor cell... Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value [作者：Abbas, S; Lugthart, S; Kavelaars, FG; Schelen, A; Koenders, JE; Zeilemaker, A; van Putten, WJL; Rijneveld, AW; Lowenberg, B; Valk, PJM,期刊：Blood, 页码：2122-2126 , 文章类型： Article，,卷期：2010年116-12] Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) were recently demonstrated in acute myeloid leukemia (AML), but their prevalence and prognostic impact remain to be explored in large extensively char... Identifying drugs that cause acute thrombocytopenia: an analysis using 3 distinct methods [作者：Reese, JA; Li, XN; Hauben, M; Aster, RH; Bougie, DW; Curtis, BR; George, JN; Vesely, SK,期刊：Blood, 页码：2127-2133 , 文章类型： Article，,卷期：2010年116-12] Drug-induced immune thrombocytopenia (DITP) is often suspected in patients with acute thrombocytopenia unexplained by other causes, but documenting that a drug is the cause of thrombocytopenia can be challenging. To prov... AMPK alpha 2 subunit is involved in platelet signaling, clot retraction, and thrombus stability [作者：Randriamboavonjy, V; Isaak, J; Fromel, T; Viollet, B; Fisslthaler, B; Preissner, KT; Fleming, I,期刊：Blood, 页码：2134-2140 , 文章类型： Article，,卷期：2010年116-12] The adenosine monophosphate (AMP)activated protein kinase (AMPK) is a regulator of energy balance at the cellular and whole-body levels, but little is known about the role of AMPK in platelet activation. We report that b... Vegf regulates embryonic erythroid development through Gata1 modulation [作者：Drogat, B; Kalucka, J; Gutierrez, L; Hammad, H; Goossens, S; Ghahremani, MF; Bartunkova, S; Haigh, K; Deswarte, K; Nyabi, O; Naessens, M; Ferrara, N; Klingmuller, U; Lambrecht, BN; Nagy, A; Philipsen, S; Haigh, JJ,期刊：Blood, 页码：2141-2151 , 文章类型： Article，,卷期：2010年116-12] To determine the role of vascular endothelial growth factor (Vegf) in embryonic erythroid development we have deleted or overexpressed Vegf specifically in the erythroid lineage using the EpoR-iCre transgenic line in com... Decreased sickle red blood cell adhesion to laminin by hydroxyurea is associated with inhibition of Lu/BCAM protein phosphorylation [作者：Bartolucci, P; Chaar, V; Picot, J; Bachir, D; Habibi, A; Fauroux, C; Galacteros, F; Colin, Y; Le Van Kim, C; El Nemer, W,期刊：Blood, 页码：2152-2159 , 文章类型： Article，,卷期：2010年116-12] Sickle cell disease is characterized by painful vaso-occlusive crises during which abnormal interactions between erythroid adhesion molecules and vessel-wall proteins are thought to play a critical role. Hydroxyurea, the... Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration [作者：Lanktree, MB; Johansen, CT; Anand, SS; Davis, AD; Miller, R; Yusuf, S; Hegele, RA,期刊：Blood, 页码：2160-2163 , 文章类型： Article，,卷期：2010年116-12] Elevated plasma plasminogen activator inhibitor-1 (PAI-1) concentration is associated with cardiovascular disease risk. PAI-1 is the primary inhibitor of fibrinolysis within both the circulation and the arterial wall, pl... The role of V delta 2-negative gamma delta T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation [作者：Knight, A; Madrigal, AJ; Grace, S; Sivakumaran, J; Kottaridis, P; Mackinnon, S; Travers, PJ; Lowdell, MW,期刊：Blood, 页码：2164-2172 , 文章类型： Article，,卷期：2010年116-12] Reactivation of cytomegalovirus (CMV) remains a serious complication after allogeneic stem cell transplantation, but the role of gamma delta T cells is undefined. We have studied the immune reconstitution of V delta 2neg... Lymphotoxin-alpha contributes to lymphangiogenesis [作者：Mounzer, RH; Svendsen, OS; Baluk, P; Bergman, CM; Padera, TP; Wiig, H; Jain, RK; McDonald, DM; Ruddle, NH,期刊：Blood, 页码：2173-2182 , 文章类型： Article，,卷期：2010年116-12] Lymphotoxin-alpha (LT alpha), lymphotoxin-beta (LT beta), and tumor necrosis factor-alpha (TNF alpha) are inflammatory mediators that play crucial roles in lymphoid organ development. We demonstrate here that LT alpha al... A revised model for the secretion of tPA and cytokines from cultured endothelial cells [作者：Knipe, L; Meli, A; Hewlett, L; Bierings, R; Dempster, J; Skehel, P; Hannah, MJ; Carter, T,期刊：Blood, 页码：2183-2191 , 文章类型： Article，,卷期：2010年116-12] Endothelial cells are reported to contain several distinct populations of regulated secretory organelles, including Weibel-Palade bodies (WPBs), the tissue plasminogen activator (tPA) organelle, and the type-2 chemokine-... Survivin localization during endomitosis of high ploidy mouse megakaryocytes [作者：McCrann, DJ; Ravid, K,期刊：Blood, 页码：2192-2193 , 文章类型： Letter，,卷期：2010年116-12] Homozygous deletion of the major alpha-globin regulatory element (MCS-R2) responsible for a severe case of hemoglobin H disease [作者：Sollaino, MC; Paglietti, ME; Loi, D; Congiu, R; Podda, R; Galanello, R,期刊：Blood, 页码：2193-2194 , 文章类型： Letter，,卷期：2010年116-12]