- How I treat Diamond-Blackfan anemia
[作者：Vlachos, A; Muir, E,期刊：Blood, 页码：3715-3723 , 文章类型： Article，,卷期：2010年116-19]
- Diamond-Blackfan anemia (DBA) is characterized by red cell failure, the presence of congenital anomalies, and cancer predisposition. In addition to being an inherited bone marrow failure syndrome, DBA is also categorized...
- Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project
[作者：Sant, M; Allemani, C; Tereanu, C; De Angelis, R; Capocaccia, R; Visser, O; Marcos-Gragera, R; Maynadie, M; Simonetti, A; Lutz, JM; Berrino, F,期刊：Blood, 页码：3724-3734 , 文章类型： Article，,卷期：2010年116-19]
- Changing definitions and classifications of hematologic malignancies (HMs) complicate incidence comparisons. HAEMACARE classified HMs into groupings consistent with the latest World Health Organization classification and...
- Treatment of progression of Philadelphia-negative myeloproliferative neoplasms to myelodysplastic syndrome or acute myeloid leukemia by azacitidine: a report on 54 cases on the behalf of the Groupe Francophone des Myelodysplasies (GFM)
[作者：Thepot, S; Itzykson, R; Seegers, V; Raffoux, E; Quesnel, B; Chait, Y; Sorin, L; Dreyfus, F; Cluzeau, T; Delaunay, J; Sanhes, L; Eclache, V; Dartigeas, C; Turlure, P; Harel, S; Salanoubat, C; Kiladjian, JJ; Fenaux, P; Ades, L,期刊：Blood, 页码：3735-3742 , 文章类型： Article，,卷期：2010年116-19]
- Transformation of Philadelphia (Ph)-negative myeloproliferative neoplasms (MPNs) to myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) is associated with poor response to chemotherapy and short survival. Fift...
- Superior outcomes associated with complete response in newly diagnosed multiple myeloma patients treated with nonintensive therapy: analysis of the phase 3 VISTA study of bortezomib plus melphalan-prednisone versus melphalan-prednisone
[作者：Harousseau, JL; Palumbo, A; Richardson, PG; Schlag, R; Dimopoulos, MA; Shpilberg, O; Kropff, M; Kentos, A; Cavo, M; Golenkov, A; Komarnicki, M; Mateos, MV; Esseltine, DL; Cakana, A; Liu, K; Deraedt, W; van de Velde, H; San Miguel, JF,期刊：Blood, 页码：3743-3750 , 文章类型： Article，,卷期：2010年116-19]
- The phase 3 Velcade as Initial Standard Therapy in Multiple Myeloma: Assessment with Melphalan and Prednisone study in newly diagnosed multiple myeloma patients ineligible for high-dose therapy demonstrated that bortezom...
- Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710
[作者：Powell, BL; Moser, B; Stock, W; Gallagher, RE; Willman, CL; Stone, RM; Rowe, JM; Coutre, S; Feusner, JH; Gregory, J; Couban, S; Appelbaum, FR; Tallman, MS; Larson, RA,期刊：Blood, 页码：3751-3757 , 文章类型： Article，,卷期：2010年116-19]
- Arsenic trioxide (As2O3) is a highly effective treatment for patients with relapsed acute promyelocytic leukemia (APL); its role as consolidation treatment for patients in first remission has not been defined. We randomi...
- Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS)
[作者：Hughes, TP; Hochhaus, A; Branford, S; Muller, MC; Kaeda, JS; Foroni, L; Druker, BJ; Guilhot, F; Larson, RA; O'Brien, SG; Rudoltz, MS; Mone, M; Wehrle, E; Modur, V; Goldman, JM; Radich, JP,期刊：Blood, 页码：3758-3765 , 文章类型： Article，,卷期：2010年116-19]
- This study examines the prognostic significance of early molecular response using an expanded dataset in chronic myeloid leukemia patients enrolled in the International Randomized Study of Interferon and STI571 (IRIS). S...
- Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome
[作者：Gohring, G; Michalova, K; Beverloo, HB; Betts, D; Harbott, J; Haas, OA; Kerndrup, G; Sainati, L; Bergstraesser, E; Hasle, H; Stary, J; Trebo, M; van den Heuvel-Eibrink, MM; Zecca, M; van Wering, ER; Fischer, A; Noellke, P; Strahm, B; Locatelli, F; Niemeyer, CM; Schlegelberger, B,期刊：Blood, 页码：3766-3769 , 文章类型： Article，,卷期：2010年116-19]
- To identify cytogenetic risk factors predicting outcome in children with advanced myelodysplastic syndrome, overall survival of 192 children prospectively enrolled in European Working Group of Myelodysplastic Syndrome in...
- Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells
[作者：Gieseke, F; Bohringer, J; Bussolari, R; Dominici, M; Handgretinger, R; Muller, I,期刊：Blood, 页码：3770-3779 , 文章类型： Article，,卷期：2010年116-19]
- Human multipotent mesenchymal stromal cells (MSCs) suppress proliferation and alloreactivity of T cells. Several signaling molecules and enzymes contribute to this effect. We focused on carbohydrate-protein interactions ...
- Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes
[作者：Wu, YL; Sommers, JA; Suhasini, AN; Leonard, T; Deakyne, JS; Mazin, AV; Shin-ya, K; Kitao, H; Brosh, RM,期刊：Blood, 页码：3780-3791 , 文章类型： Article，,卷期：2010年116-19]
- Fanconi anemia (FA) is a genetic disease characterized by congenital abnormalities, bone marrow failure, and susceptibility to leukemia and other cancers. FANCJ, one of 13 genes linked to FA, encodes a DNA helicase propo...
- Targeted deletion of the tachykinin 4 gene (TAC4(-/-)) influences the early stages of B lymphocyte development
[作者：Berger, A; Benveniste, P; Corfe, SA; Tran, AH; Barbara, M; Wakeham, A; Mak, TW; Iscove, NN; Paige, CJ,期刊：Blood, 页码：3792-3801 , 文章类型： Article，,卷期：2010年116-19]
- Hemokinin-1 (HK-1), encoded by the TAC4 gene, is a tachykinin peptide that is predominantly expressed in non-neuronal cells, such as immune cells. We have disrupted the mouse TAC4 gene to obtain a better understanding of...
- Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors
[作者：Afonso, PV; Mekaouche, M; Mortreux, F; Toulza, F; Moriceau, A; Wattel, E; Gessain, A; Bangham, CRM; Dubreuil, G; Plumelle, Y; Hermine, O; Estaquier, J; Mahieux, R,期刊：Blood, 页码：3802-3808 , 文章类型： Article，,卷期：2010年116-19]
- Approximately 3% of all human T-lymphotropic virus type 1 (HTLV-1)-infected persons will develop a disabling inflammatory disease of the central nervous system known as HTLV-1-associated myelopathy/tropical spastic parap...
- Requirement of the human T-cell leukemia virus p12 and p30 products for infectivity of human dendritic cells and macaques but not rabbits
[作者：Valeri, VW; Hryniewicz, A; Andresen, V; Jones, K; Fenizia, C; Bialuk, I; Chung, HK; Fukumoto, R; Parks, RW; Ferrari, MG; Nicot, C; Cecchinato, V; Ruscetti, F; Franchini, G,期刊：Blood, 页码：3809-3817 , 文章类型： Article，,卷期：2010年116-19]
- The identification of the genes necessary for human T-cell leukemia virus (HTLV-1) persistence in humans may provide targets for therapeutic approaches. We demonstrate that ablation of the HTLV-1 genes encoding p12, p30,...
- Elevated frequencies of highly activated CD4(+) T cells in HIV+ patients developing immune reconstitution inflammatory syndrome
[作者：Antonelli, LRV; Mahnke, Y; Hodge, JN; Porter, BO; Barber, DL; DerSimonian, R; Greenwald, JH; Roby, G; Mican, J; Sher, A; Roederer, M; Sereti, I,期刊：Blood, 页码：3818-3827 , 文章类型： Article，,卷期：2010年116-19]
- Immune reconstitution inflammatory syndrome (IRIS) is a considerable problem in the treatment of HIV-infected patients. To identify immunologic correlates of IRIS, we characterized T-cell phenotypic markers and serum cyt...
- Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody
[作者：Cheong, C; Choi, JH; Vitale, L; He, LZ; Trumpfheller, C; Bozzacco, L; Do, Y; Nchinda, G; Park, SH; Dandamudi, DB; Shrestha, E; Pack, M; Lee, HW; Keler, T; Steinman, RM; Park, CG,期刊：Blood, 页码：3828-3838 , 文章类型： Article，,卷期：2010年116-19]
- Protein vaccines for T-cell immunity are not being prioritized because of poor immunogenicity. To overcome this hurdle, proteins are being targeted to maturing dendritic cells (DCs) within monoclonal antibodies (mAbs) to...
- Evidence of dysregulation of dendritic cells in primary HIV infection
[作者：Sabado, RL; O'Brien, M; Subedi, A; Qin, L; Hu, N; Taylor, E; Dibben, O; Stacey, A; Fellay, J; Shianna, KV; Siegal, F; Shodell, M; Shah, K; Larsson, M; Lifson, J; Nadas, A; Marmor, M; Hutt, R; Margolis, D; Garmon, D; Markowitz, M; Valentine, F; Borrow, P; Bhardwaj, N,期刊：Blood, 页码：3839-3852 , 文章类型： Article，,卷期：2010年116-19]
- Myeloid and plasmacytoid dendritic cells (DCs) are important mediators of both innate and adaptive immunity against pathogens such as HIV. During the course of HIV infection, blood DC numbers fall substantially. In the p...
- Expression patterns of NKG2A, KIR, and CD57 define a process of CD56(dim) NK-cell differentiation uncoupled from NK-cell education
[作者：Bjorkstrom, NK; Riese, P; Heuts, F; Andersson, S; Fauriat, C; Ivarsson, MA; Bjorklund, AT; Flodstrom-Tullberg, M; Michaelsson, J; Rottenberg, ME; Guzman, CA; Ljunggren, HG; Malmberg, KJ,期刊：Blood, 页码：3853-3864 , 文章类型： Article，,卷期：2010年116-19]
Natural killer (NK) cells are lymphocytes of the innate immune system that, following differentiation from CD56(bright) to CD56(dim) cells, have been thought to retain fixed functional and phenotypic properties throug...
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