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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共30条记录   Crystallographic and Nuclear Magnetic Resonance Evaluation of the Impact of Peptide Binding to the Second PDZ Domain of Protein Tyrosine Phosphatase 1E [作者：Zhang, J; Sapienza, PJ; Ke, HM; Chang, A; Hengel, SR; Wang, HC; Phillips, GN; Lee, AL,期刊：Biochemistry, 页码：9280-9291 , 文章类型： Article，,卷期：2010年49-43] PDZ (PSD95/Discs large/ZO-1) domains are ubiquitous protein interaction motifs found in scaffolding proteins involved in signal transduction. Despite the fact that many PDZ domains show a limited tendency to undergo stru... Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis [作者：Drake, EJ; Duckworth, BP; Neres, J; Aldrich, CC; Gulick, AM,期刊：Biochemistry, 页码：9292-9305 , 文章类型： Article，,卷期：2010年49-43] The human pathogen Acinetobacter baumannii produces a siderophore called acinetobactin that is derived from one molecule each of threonine, histidine, and 2,3-dihydroxybenzoic acid (DHB). The activity of several nonribos... Structure and Mechanism of ORF36, an Amino Sugar Oxidizing Enzyme in Everninomicin Biosynthesis [作者：Vey, JL; Al-Mestarihi, A; Hu, YF; Funk, MA; Bachmann, BO; Iverson, TM,期刊：Biochemistry, 页码：9306-9317 , 文章类型： Article，,卷期：2010年49-43] Everninomicin is a highly modified octasaccharide that belongs to the orthosomycin family of antibiotics and possesses potent Gram-positive antibiotic activity, including broad-spectrum efficacy against multidrug resi... Phosphatidylinositol 4,5-Bisphosphate-Induced Conformational Change of Ezrin and Formation of Ezrin Oligomers [作者：Carvalho, K; Khalifat, N; Maniti, O; Nicolas, C; Arold, S; Picart, C; Ramos, L,期刊：Biochemistry, 页码：9318-9327 , 文章类型： Article，,卷期：2010年49-43] The plasma membrane-cytoskeleton interface is a dynamic structure involved in a variety of cellular events. Ezrin, a protein from the ERM family, provides a direct linkage between the cytoskeleton and the membrane via it... Acid-Induced Aggregation of Human Monoclonal IgG1 and IgG2: Molecular Mechanism and the Effect of Solution Composition [作者：Hari, SB; Lau, H; Razinkov, VI; Chen, SA; Latypov, RF,期刊：Biochemistry, 页码：9328-9338 , 文章类型： Article，,卷期：2010年49-43] The prevention of aggregation in therapeutic antibodies is of great importance to the biopharmaceutical industry. In our investigation, acid-induced aggregation of monoclonal IgG1 and IgG2 antibodies was studied at pH 3.... Hepatic alpha-Tocopherol Transfer Protein: Ligand-Induced Protection from Proteasomal Degradation [作者：Thakur, V; Morley, S; Manor, D,期刊：Biochemistry, 页码：9339-9344 , 文章类型： Article，,卷期：2010年49-43] There are eight naturally occurring forms of the dietary antioxidant vitamin E. Of these, only a-tocopherol is retained at high levels in vertebrate plasma and tissues. This selectivity is achieved in part by the action ... The Conformation and the Aggregation Kinetics of alpha-Synuclein Depend on the Proline Residues in Its C-Terminal Region [作者：Meuvis, J; Gerard, M; Desender, L; Baekelandt, V; Engelborghs, Y,期刊：Biochemistry, 页码：9345-9352 , 文章类型： Article，,卷期：2010年49-43] The neuronal protein alpha-synuclein (alpha-syn) plays a central role in Parkinson's disease (PD). The pathological features of PD are the loss of dopaminergic neurons in the substantia nigra pars compacta and the presen... Myole Binds Anionic Phospholipids with High Affinity [作者：Feeser, EA; Ignacio, CMG; Krendel, M; Ostap, EM,期刊：Biochemistry, 页码：9353-9360 , 文章类型： Article，,卷期：2010年49-43] Myole is a single-headed motor protein that has been shown to play roles in clathrin-mediated endocytosis in HeLa cells and podocyte function in the kidney. The myole C-terminal tail domain includes a basic region that i... Long-Range Interaction Networks in the Function and Fidelity of Poliovirus RNA-Dependent RNA Polymerase Studied by Nuclear Magnetic Resonance [作者：Yang, XR; Welch, JL; Arnold, JJ; Boehr, DD,期刊：Biochemistry, 页码：9361-9371 , 文章类型： Article，,卷期：2010年49-43] The fidelity of the poliovirus RNA-dependent RNA polymerase (3D(pol)) plays a direct role in the genomic evolution and pathogenesis of the virus. A single site mutation (Gly64Ser) that is remote from the catalytic center... Positional Effects on Helical Ala-Based Peptides [作者：Cheng, RP; Girinath, P; Suzuki, Y; Kuo, HT; Hsu, HC; Wang, WR; Yang, PA; Gullickson, D; Wu, CH; Koyack, MJ; Chiu, HP; Weng, YJ; Hart, P; Kokona, B; Fairman, R; Lin, TE; Barrett, O,期刊：Biochemistry, 页码：9372-9384 , 文章类型： Article，,卷期：2010年49-43] Helix-coil equilibrium studies are important for understanding helix formation in protein folding, and for helical foldamer design. The quantitative description of a helix using statistical mechanical models is based on ... Histidine 197 in Release Factor 1 Is Essential for A Site Binding and Peptide Release [作者：Field, A; Hetrick, B; Mathew, M; Joseph, S,期刊：Biochemistry, 页码：9385-9390 , 文章类型： Article，,卷期：2010年49-43] Class I peptide release factors I and 2 (RF1 and RF2, respectively) recognize the stop codons in the ribosomal decoding center and catalyze peptidyl-tRNA hydrolysis. High-fidelity stop codon recognition by these release ... A Conserved Glutamate Controls the Commitment to Acyl-Adenylate Formation in Asparagine Synthetase [作者：Meyer, ME; Gutierrez, JA; Raushel, FM; Richards, NGJ,期刊：Biochemistry, 页码：9391-9401 , 文章类型： Article，,卷期：2010年49-43] Inhibitor docking studies have implicated a conserved glutamate residue (Glu-348) as a general base in the synthetase active site of the enzyme asparagine synthetase B from Escherichia coil (AS-B). We now report steady-s... SufD and SufC ATPase Activity Are Required for Iron Acquisition during in Vivo Fe-S Cluster Formation on SufB [作者：Saini, A; Mapolelo, DT; Chahal, HK; Johnson, MK; Outten, FW,期刊：Biochemistry, 页码：9402-9412 , 文章类型： Article，,卷期：2010年49-43] In vivo biogenesis of Fe-S cluster cofactors requires complex biosynthetic machinery to limit release of iron and sulfide, to protect the Fe-S cluster from oxidation, and to target the Fe-S cluster to the correct apoenzy... Mechanistic Studies of Agmatine Deiminase from Multiple Bacterial Species [作者：Jones, JE; Dreyton, CJ; Flick, H; Causey, CP; Thompson, PR,期刊：Biochemistry, 页码：9413-9423 , 文章类型： Article，,卷期：2010年49-43] One subfamily of guanidino group-modifying enzymes (GMEs) consists of the agmatine deiminases (AgDs). These enzymes catalyze the conversion of agmatine (decarboxylated arginine) to N-carbamoyl putrescine and ammonia. In ...