- Allele-Selective Inhibition of Mutant Huntingtin Expression with Antisense Oligonucleotides Targeting the Expanded CAG Repeat
[作者:Gagnon, KT; Pendergraff, HM; Deleavey, GF; Swayze, EE; Potier, P; Randolph, J; Roesch, EB; Chattopadhyaya, J; Damha, MJ; Bennett, CF; Montaillier, C; Lemaitre, M; Corey, DR,期刊:Biochemistry, 页码:10166-10178 , 文章类型: Article,,卷期:2010年49-47]
- Huntington's disease (HD) is a currently incurable neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat within the huntingtin (HTT) gene. Therapeutic approaches include selectively inhibiting t...
- Kinetic Basis of Sugar Selection by a Y-Family DNA Polymerase from Sulfolobus solfataricus P2
[作者:Sherrer, SM; Beyer, DC; Xia, CX; Fowler, JD; Suo, ZC,期刊:Biochemistry, 页码:10179-10186 , 文章类型: Article,,卷期:2010年49-47]
- DNA polymerases use either a bulky active site residue or a backbone segment to select against ribonucleotides in order to faithfully replicate cellular genomes. Here, we demonstrated that an active site mutation (Y12A) ...
- Structural Basis of Ubiquitin Recognition by Translesion Synthesis DNA Polymerase i
[作者:Cui, GF; Benirschke, RC; Tuan, HF; Juranic, N; Macura, S; Botuyan, MV; Mer, G,期刊:Biochemistry, 页码:10198-10207 , 文章类型: Article,,卷期:2010年49-47]
- Cells have evolved mutagenic bypass mechanisms that prevent stalling of the replication machinery at DNA lesions. This process, translesion DNA synthesis (TLS), involves switching from high-fidelity DNA polymerases to sp...
- Regulation of Influenza RNA Polymerase Activity and the Switch between Replication and Transcription by the Concentrations of the vRNA 5 ' End, the Cap Source, and the Polymerase
[作者:Olson, AC; Rosenblum, E; Kuchta, RD,期刊:Biochemistry, 页码:10208-10215 , 文章类型: Article,,卷期:2010年49-47]
- The influenza RNA-dependent RNA polymerase (RdRp) both replicates the flu's RNA genome and transcribes its mRNA. Replication occurs de novo; however, initiation of transcription requires a 7-methylguanosine 5'-capped pri...
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