- Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy
[作者:Abe, Y; Gor, J; Bracewell, DG; Perkins, SJ; Dalby, PA,期刊:Biochemical Journal, 页码:101-111 , 文章类型: Article,,卷期:2010年432-Part 1]
- Of the four human IgG antibody subclasses IgG1-IgG4, IgG4 is of interest in that it does not activate complement and exhibits atypical self-association, including the formation of bispecifie antibodies. The solution stru...
- The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of beta-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes
[作者:Chien, V; Aitken, JF; Zhang, SP; Buchanan, CM; Hickey, A; Brittain, T; Cooper, GJS; Loomes, KM,期刊:Biochemical Journal, 页码:113-121 , 文章类型: Article,,卷期:2010年432-Part 1]
- Misfolding of the islet beta-cell peptide hA (human amylin) into beta-sheet-containing oligomers is linked to beta-cell apoptosis and the pathogenesis of T2DM (Type 2 diabetes mellitus). In the present study, we have inv...
- Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron
[作者:Lane, DJR; Robinson, SR; Czerwinska, H; Bishop, GM; Lawen, A,期刊:Biochemical Journal, 页码:123-132 , 文章类型: Article,,卷期:2010年432-Part 1]
- Astrocytes are central to iron and ascorbate homoeostasis within the brain. Although NTBI (non-transferrin-bound iron) may be a major form of iron imported by astrocytes in vivo, the mechanisms responsible remain unclear...
- Peptidoglycan derived from Staphylococcus epidermidis induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells
[作者:Robertson, J; Lang, S; Lambert, PA; Martin, PE,期刊:Biochemical Journal, 页码:133-143 , 文章类型: Article,,卷期:2010年432-Part 1]
- Gram-positive bacterial cell wall components including PGN (peptidoglycan) elicit a potent pro-inflammatory response in diverse cell types, including endothelial cells, by activating TLR2 (Toll-like receptor 2) signallin...
- Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake
[作者:Mardini, L; Gasiorek, J; Derjuga, A; Carriere, L; Schranzhofer, M; Paw, BH; Ponka, P; Blank, V,期刊:Biochemical Journal, 页码:145-151 , 文章类型: Article,,卷期:2010年432-Part 1]
Late-stage erythroid cells synthesize large quantities of haemoglobin, a process requiring the co-ordinated regulation of globin and haem synthesis as well as iron uptake. In the present study, we investigated the rol...
- Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells
[作者:Matthews, SA; Navarro, MN; Sinclair, LV; Emslie, E; Feijoo-Carnero, C; Cantrell, DA,期刊:Biochemical Journal, 页码:153-163 , 文章类型: Article,,卷期:2010年432-Part 1]
- Mammalian PKD (protein kinase D) isoforms have been implicated in the regulation of diverse biological processes in response to diacylglycerol and PKC (protein kinase C) signalling. To compare the functions of PKD1 and P...
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