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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共48条记录   The cellular response to hypoxia: tuning the system with microRNAs [作者：Loscalzo, J,期刊：Journal of clinical investigation, 页码：3815-3817 , 文章类型： Editorial Material，,卷期：2010年120-11] Adaptation to hypoxia is an essential cellular response controlled by the oxygen-sensitive master transcription factor hypoxia-inducible factor 1 (HIF-1). HIF-1 expression is also controlled by specific microRNAs and, in... The magic and mystery of miR-21 [作者：Morrisey, EE,期刊：Journal of clinical investigation, 页码：3817-3819 , 文章类型： Editorial Material，,卷期：2010年120-11] MicroRNAs (miRNAs) are potent regulators of mRNA stability and thereby protein expression. As such, miRNAs have become of interest as possible therapeutics and/or therapeutic targets. In this context, small complementary... The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells [作者：Kossatz, U; Breuhahn, K; Wolf, B; Hardtke-Wolenski, M; Wilkens, L; Steinemann, D; Singer, S; Brass, F; Kubicka, S; Schlegelberger, B; Schirmacher, P; Manns, MP; Singer, JD; Malek, NP,期刊：Journal of clinical investigation, 页码：3820-3833 , 文章类型： Article，,卷期：2010年120-11] Cyclin E is often overexpressed in cancer tissue, leading to genetic instability and aneuploidy. Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E. He... Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells [作者：Vinciguerra, P; Godinho, SA; Parmar, K; Pellman, D; D'Andrea, AD,期刊：Journal of clinical investigation, 页码：3834-3842 , 文章类型： Article，,卷期：2010年120-11] Fanconi anemia (FA) is a genomic instability disorder characterized by bone marrow failure and cancer predisposition. FA is caused by mutations in any one of several genes that encode proteins cooperating in a repair pat... Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients [作者：Glynn, SA; Boersma, BJ; Dorsey, TH; Yi, M; Yfantis, HG; Ridnour, LA; Martin, DN; Switzer, CH; Hudson, RS; Wink, DA; Lee, DH; Stephens, RM; Ambs, S,期刊：Journal of clinical investigation, 页码：3843-3854 , 文章类型： Article，,卷期：2010年120-11] Inducible nitric oxide synthase (NOS2) is involved in wound healing, angiogenesis, and carcinogenesis. NOS2 upregulation and increased nitric oxide (NO) production affect the redox state of cells and can induce protein, ... Nonhematopoietic antigen blocks memory programming of alloreactive CD8(+) T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation [作者：Flutter, B; Edwards, N; Fallah-Arani, F; Henderson, S; Chai, JG; Sivakumaran, S; Ghorashian, S; Bennett, CL; Freeman, GJ; Sykes, M; Chakraverty, R,期刊：Journal of clinical investigation, 页码：3855-3868 , 文章类型： Article，,卷期：2010年120-11] Allogeneic blood or BM transplantation (BMT) is the most commonly applied form of adoptive cellular therapy for cancer. In this context, the ability of donor T cells to respond to recipient antigens is coopted to generat... MHC-restricted fratricide of human lymphocytes expressing survivin-specific transgenic T cell receptors [作者：Leisegang, M; Wilde, S; Spranger, S; Milosevic, S; Frankenberger, B; Uckert, W; Schendel, DJ,期刊：Journal of clinical investigation, 页码：3869-3877 , 文章类型： Article，,卷期：2010年120-11] The apoptosis inhibitor protein survivin is overexpressed in many tumors, making it a candidate target molecule for various forms of immunotherapy. To explore survivin as a target antigen for adoptive T cell therapy usin... Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques [作者：Titanji, K; Velu, V; Chennareddi, L; Vijay-Kumar, M; Gewirtz, AT; Freeman, GJ; Amara, RR,期刊：Journal of clinical investigation, 页码：3878-3890 , 文章类型： Article，,卷期：2010年120-11] Rapid progression to AIDS is a significant problem, especially in developing countries, where the majority of HIV-infected individuals reside. As rapid disease progression is also frequently observed in SIV-infected maca... Placental growth factor mediates aldosterone-dependent vascular injury in mice [作者：Jaffe, IZ; Newfell, BG; Aronovitz, M; Mohammad, NN; McGraw, AP; Perreault, RE; Carmeliet, P; Ehsan, A; Mendelsohn, ME,期刊：Journal of clinical investigation, 页码：3891-3900 , 文章类型： Article，,卷期：2010年120-11] In clinical trials, aldosterone antagonists reduce cardiovascular ischemia and mortality by unknown mechanisms. Aldosterone is a steroid hormone that signals through renal mineralocorticoid receptors (MRs) to regulate bl... MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice [作者：Wu, ZD; Jiao, P; Huang, XM; Feng, B; Feng, YJ; Yang, SY; Hwang, P; Du, J; Nie, YH; Xiao, GZ; Xu, HY,期刊：Journal of clinical investigation, 页码：3901-3911 , 文章类型： Article，,卷期：2010年120-11] Insulin resistance results in dysregulated hepatic gluconeogenesis that contributes to obesity-related hyperglycemia and progression of type 2 diabetes mellitus (T2DM). Recent studies show that MAPK phosphatase-3 (MKP-3)... Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice [作者：Patrick, DM; Montgomery, RL; Qi, XX; Obad, S; Kauppinen, S; Hill, JA; van Rooij, E; Olson, EN,期刊：Journal of clinical investigation, 页码：3912-3916 , 文章类型： Article，,卷期：2010年120-11] MicroRNAs inhibit mRNA translation or promote mRNA degradation by binding complementary sequences in 3' untranslated regions of target mRNAs. MicroRNA-21 (miR-21) is upregulated in response to cardiac stress, and its inh... Infusion of mature megakaryocytes into mice yields functional platelets [作者：Fuentes, R; Wang, YH; Hirsch, J; Wang, C; Rauova, L; Worthen, GS; Kowalska, MA; Poncz, M,期刊：Journal of clinical investigation, 页码：3917-3922 , 文章类型： Article，,卷期：2010年120-11] Thrombopoiesis, the process by which circulating platelets arise from megakaryocytes, remains incompletely understood. Prior studies suggest that megakaryocytes shed platelets in the pulmonary vasculature. To better unde... hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing [作者：Goehe, RW; Shultz, JC; Murudkar, C; Usanovic, S; Lamour, NF; Massey, DH; Zhang, LA; Camidge, DR; Shay, JW; Minna, JD; Chalfant, CE,期刊：Journal of clinical investigation, 页码：3923-3939 , 文章类型： Article，,卷期：2010年120-11] Caspase-9 is involved in the intrinsic apoptotic pathway and suggested to play a role as a tumor suppressor. Little is known about the mechanisms governing caspase-9 expression, but post-transcriptional pre-mRNA processi... Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models [作者：Vicent, S; Chen, R; Sayles, LC; Lin, CW; Walker, RG; Gillespie, AK; Subramanian, A; Hinkle, G; Yang, XP; Saif, S; Root, DE; Huff, V; Hahn, WC; Sweet-Cordero, EA,期刊：Journal of clinical investigation, 页码：3940-3952 , 文章类型： Article，,卷期：2010年120-11] KRAS is one of the most frequently mutated human oncogenes. In some settings, oncogenic KRAS can trigger cellular senescence, whereas in others it produces hyperproliferation. Elucidating the mechanisms regulating these ... Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice [作者：Chinnasamy, D; Yu, ZY; Theoret, MR; Zhao, YB; Shrimali, RK; Morgan, RA; Feldman, SA; Restifo, NP; Rosenberg, SA,期刊：Journal of clinical investigation, 页码：3953-3968 , 文章类型： Article，,卷期：2010年120-11] Immunotherapies based on adoptive cell transfer are highly effective in the treatment of metastatic melanoma, but the use of this approach in other cancer histologies has been hampered by the identification of appropriat... The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice [作者：Bongers, G; Maussang, D; Muniz, LR; Noriega, VM; Fraile-Ramos, A; Barker, N; Marchesi, F; Thirunarayanan, N; Vischer, HF; Qin, LH; Mayer, L; Harpaz, N; Leurs, R; Furtado, GC; Clevers, H; Tortorella, D; Smit, MJ; Lira, SA,期刊：Journal of clinical investigation, 页码：3969-3978 , 文章类型： Article，,卷期：2010年120-11] US28 is a constitutively active chemokine receptor encoded by CMV (also referred to as human herpesvirus 5), a highly prevalent human virus that infects a broad spectrum of cells, including intestinal epithelial cells (I...