- Influence of Apolipoprotein (Apo) A-I Structure on Nascent High Density Lipoprotein (HDL) Particle Size Distribution
[作者:Vedhachalam, C; Chetty, PS; Nickel, M; Dhanasekaran, P; Lund-Katz, S; Rothblat, GH; Phillips, MC,期刊:Journal of Biological Chemistry, 页码:31965-31973 , 文章类型: Article,,卷期:2010年285-42]
- The principal protein of high density lipoprotein (HDL), apolipoprotein (apo) A-I, in the lipid-free state contains two tertiary structure domains comprising an N-terminal helix bundle and a less organized C-terminal dom...
- Alternatively Spliced Caspase-6B Isoform Inhibits the Activation of Caspase-6A
[作者:Lee, AW; Champagne, N; Wang, XJ; Su, XD; Goodyer, C; Leblanc, AC,期刊:Journal of Biological Chemistry, 页码:31974-31984 , 文章类型: Article,,卷期:2010年285-42]
- Caspase-6 (Casp6) is activated early in Alzheimer disease and involved in axonal degeneration, but the regulation of Casp6 activity has not been explored. Several alternatively spliced forms of caspases act as inhibitors...
- Ablation of Succinate Production from Glucose Metabolism in the Procyclic Trypanosomes Induces Metabolic Switches to the Glycerol 3-Phosphate/Dihydroxyacetone Phosphate Shuttle and to Proline Metabolism
[作者:Ebikeme, C; Hubert, J; Biran, M; Gouspillou, G; Morand, P; Plazolles, N; Guegan, F; Diolez, P; Franconi, JM; Portais, JC; Bringaud, F,期刊:Journal of Biological Chemistry, 页码:32312-32324 , 文章类型: Article,,卷期:2010年285-42]
- Trypanosoma brucei is a parasitic protist that undergoes a complex life cycle during transmission from its mammalian host (bloodstream forms) to the midgut of its insect vector (procyclic form). In both parasitic forms, ...
- Regulation of Response Regulator Autophosphorylation through Interdomain Contacts
[作者:Barbieri, CM; Mack, TR; Robinson, VL; Miller, MT; Stock, AM,期刊:Journal of Biological Chemistry, 页码:32325-32335 , 文章类型: Article,,卷期:2010年285-42]
- DNA-binding response regulators (RRs) of the OmpR/PhoB subfamily alternate between inactive and active conformational states, with the latter having enhanced DNA-binding affinity. Phosphorylation of an aspartate residue ...
- p38 Regulates Expression of Osteoblast-specific Genes by Phosphorylation of Osterix
[作者:Ortuno, MJ; Ruiz-Gaspa, S; Rodriguez-Carballo, E; Susperregui, ARG; Bartrons, R; Rosa, JL; Ventura, F,期刊:Journal of Biological Chemistry, 页码:31985-31994 , 文章类型: Article,,卷期:2010年285-42]
- Osterix, a zinc finger transcription factor, is specifically expressed in osteoblasts and osteocytes of all developing bones. Because no bone formation occurs in Osx-null mice, Osterix is thought to be an essential regul...
- SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells
[作者:Nasrin, N; Wu, XP; Fortier, E; Feng, YJ; Bare, OC; Chen, SM; Ren, XL; Wu, ZD; Streeper, RS; Bordone, L,期刊:Journal of Biological Chemistry, 页码:31995-32002 , 文章类型: Article,,卷期:2010年285-42]
- SIRT4, a member of the sirtuin family, has been implicated in the regulation of insulin secretion by modulation of glutamate dehydrogenase. However, the role of this enzyme in the regulation of metabolism in other tissue...
- Bacterial Macroscopic Rope-like Fibers with Cytopathic and Adhesive Properties
[作者:Xicohtencatl-Cortes, J; Saldana, Z; Deng, WY; Castaneda, E; Freer, E; Tarr, PI; Finlay, BB; Puente, JL; Giron, JA,期刊:Journal of Biological Chemistry, 页码:32336-32342 , 文章类型: Article,,卷期:2010年285-42]
- We present a body of ultrastructural, biochemical, and genetic evidence that demonstrates the oligomerization of virulence-associated autotransporter proteins EspC or EspP produced by deadly human pathogens enterohemorrh...
- Oxidized Cholesteryl Esters and Phospholipids in Zebrafish Larvae Fed a High Cholesterol Diet MACROPHAGE BINDING AND ACTIVATION
[作者:Fang, LH; Harkewicz, R; Hartvigsen, K; Wiesner, P; Choi, SH; Almazan, F; Pattison, J; Deer, E; Sayaphupha, T; Dennis, EA; Witztum, JL; Tsimikas, S; Miller, YI,期刊:Journal of Biological Chemistry, 页码:32343-32351 , 文章类型: Article,,卷期:2010年285-42]
- A novel hypercholesterolemic zebrafish model has been developed to study early events of atherogenesis. This model utilizes optically transparent zebrafish larvae, fed a high cholesterol diet (HCD), to monitor processes ...
- Hyaluronan Synthesis Mediates the Fibrotic Response of Keratocytes to Transforming Growth Factor beta
[作者:Guo, NX; Li, XA; Mann, MM; Funderburgh, ML; Du, YQ; Funderburgh, JL,期刊:Journal of Biological Chemistry, 页码:32012-32019 , 文章类型: Article,,卷期:2010年285-42]
- TGF beta induces fibrosis in healing corneal wounds, and in vitro corneal keratocytes up-regulate expression of several fibrosis-related genes in response to TGF beta. Hyaluronan (HA) accumulates in healing corneas, and ...
- ATP Binding to Hsp90 Is Sufficient for Effective Chaperoning of p53 Protein
[作者:Walerych, D; Gutkowska, M; Klejman, MP; Wawrzynow, B; Tracz, Z; Wiech, M; Zylicz, M; Zylicz, A,期刊:Journal of Biological Chemistry, 页码:32020-32028 , 文章类型: Article,,卷期:2010年285-42]
- Hsp90 is a ubiquitous, ATP-dependent chaperone, essential for eukaryotes. It possesses a broad spectrum of substrates, among which is the p53 transcription factor, encoded by a tumor-suppressor gene. Here, we elucidate t...
- Uptake of Selenite by Saccharomyces cerevisiae Involves the High and Low Affinity Orthophosphate Transporters
[作者:Lazard, M; Blanquet, S; Fisicaro, P; Labarraque, G; Plateau, P,期刊:Journal of Biological Chemistry, 页码:32029-32037 , 文章类型: Article,,卷期:2010年285-42]
- Although the general cytotoxicity of selenite is well established, the mechanism by which this compound crosses cellular membranes is still unknown. Here, we show that in Saccharomyces cerevisiae, the transport system us...
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