个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共83条记录   Calreticulin Controls the Rate of Assembly of CD1d Molecules in the Endoplasmic Reticulum [作者：Zhu, YJ; Zhang, W; Veerapen, N; Besra, G; Cresswell, P,期刊：Journal of Biological Chemistry, 页码：38283-38292 , 文章类型： Article，,卷期：2010年285-49] CD1d is an MHC class I-like molecule comprised of a transmembrane glycoprotein (heavy chain) associated with beta(2)-microglobulin (beta(2)m) that presents lipid antigens to NKT cells. Initial folding of the heavy chain ... Thrombin Inhibition by Serpins Disrupts Exosite II [作者：Li, W; Johnson, DJD; Adams, TE; Pozzi, N; De Filippis, V; Huntington, JA,期刊：Journal of Biological Chemistry, 页码：38621-38629 , 文章类型： Article，,卷期：2010年285-49] Thrombin uses three principal sites, the active site, exosite I, and exosite II, for recognition of its many cofactors and substrates. It is synthesized in the zymogen form, prothrombin, and its activation at the end of ... Nucleocytoplasmic Shuttling of Dysbindin-1, a Schizophrenia-related Protein, Regulates Synapsin I Expression [作者：Fei, EK; Ma, XC; Zhu, CQ; Xue, T; Yan, J; Xu, YX; Zhou, JN; Wang, GH,期刊：Journal of Biological Chemistry, 页码：38630-38640 , 文章类型： Article，,卷期：2010年285-49] Dysbindin-1 is a 50-kDa coiled-coil-containing protein encoded by the gene DTNBP1 (dystrobrevin-binding protein 1), a candidate genetic factor for schizophrenia. Genetic variations in this gene confer a susceptibility to... Nedd4-1 and beta-Arrestin-1 Are Key Regulators of Na+/H+ Exchanger 1 Ubiquitylation, Endocytosis, and Function [作者：Simonin, A; Fuster, D,期刊：Journal of Biological Chemistry, 页码：38293-38303 , 文章类型： Article，,卷期：2010年285-49] The ubiquitously expressed mammalian Na+/H+ exchanger 1 (NHE1) controls cell volume and pH but is also critically involved in complex biological processes like cell adhesion, cell migration, cell proliferation, and mecha... Archazolid A Binds to the Equatorial Region of the c-Ring of the Vacuolar H+-ATPase [作者：Bockelmann, S; Menche, D; Rudolph, S; Bender, T; Grond, S; von Zezschwitz, P; Muench, SP; Wieczorek, H; Huss, M,期刊：Journal of Biological Chemistry, 页码：38304-38314 , 文章类型： Article，,卷期：2010年285-49] The macrolactone archazolid is a novel, highly specific V-ATPase inhibitor with an IC50 value in the low nanomolar range. The binding site of archazolid is presumed to overlap with the binding site of the established ple... PfSRPK1, a Novel Splicing-related Kinase from Plasmodium falciparum [作者：Dixit, A; Singh, PK; Sharma, GP; Malhotra, P; Sharma, P,期刊：Journal of Biological Chemistry, 页码：38315-38323 , 文章类型： Article，,卷期：2010年285-49] Even though it is increasingly evident that post-transcriptional events like mRNA processing and splicing may regulate gene expression and proteome diversity of malaria parasite Plasmodium, molecular mechanisms that regu... Oxidative Stress Inhibits Vascular K-ATP Channels by S-Glutathionylation [作者：Yang, Y; Shi, WW; Cui, NR; Wu, ZY; Jiang, C,期刊：Journal of Biological Chemistry, 页码：38641-38648 , 文章类型： Article，,卷期：2010年285-49] The K-ATP channel is an important player in vascular tone regulation. Its opening and closure lead to vasodilation and vasoconstriction, respectively. Such functions may be disrupted in oxidative stress seen in a variety... Affinity, Avidity, and Kinetics of Target Sequence Binding to LC8 Dynein Light Chain Isoforms [作者：Radnai, L; Rapali, P; Hodi, Z; Suveges, D; Molnar, T; Kiss, B; Becsi, B; Erdodi, F; Buday, L; Kardos, J; Kovacs, M; Nyitray, L,期刊：Journal of Biological Chemistry, 页码：38649-38657 , 文章类型： Article，,卷期：2010年285-49] LC8 dynein light chain (DYNLL) is a highly conserved eukaryotic hub protein with dozens of binding partners and various functions beyond being a subunit of dynein and myosin Va motor proteins. Here, we compared the kinet... Heat Shock Protein 90 as a Drug Target against Protozoan Infections BIOCHEMICAL CHARACTERIZATION OF HSP90 FROM PLASMODIUM FALCIPARUM AND TRYPANOSOMA EVANSI AND EVALUATION OF ITS INHIBITOR AS A CANDIDATE DRUG [作者：Pallavi, R; Roy, N; Nageshan, RK; Talukdar, P; Pavithra, SR; Reddy, R; Venketesh, S; Kumar, R; Gupta, AK; Singh, RK; Yadav, SC; Tatu, U,期刊：Journal of Biological Chemistry, 页码：37964-37975 , 文章类型： Article，,卷期：2010年285-49] Using a pharmacological inhibitor of Hsp90 in cultured malarial parasite, we have previously implicated Plasmodium falciparum Hsp90 (PfHsp90) as a drug target against malaria. In this study, we have biochemically charact... Identification of Interacting Hot Spots in the beta 3 Integrin Stalk Using Comprehensive Interface Design [作者：Donald, JE; Zhu, H; Litvinov, RI; DeGrado, WF; Bennett, JS,期刊：Journal of Biological Chemistry, 页码：38658-38665 , 文章类型： Article，,卷期：2010年285-49] Protein-protein interfaces are usually large and complementary surfaces, but specific side chains, representing energetic "hot spots," often contribute disproportionately to binding free energy. We used a computational m... STIM1-dependent and STIM1-independent Function of Transient Receptor Potential Canonical (TRPC) Channels Tunes Their Store-operated Mode [作者：Lee, KP; Yuan, JP; So, I; Worley, PF; Muallem, S,期刊：Journal of Biological Chemistry, 页码：38666-38673 , 文章类型： Article，,卷期：2010年285-49] Ca(2+)influx by store-operated Ca2+ channels is a key component of the receptor-evoked Ca2+ signal. In all cells examined, transient receptor potential canonical (TRPC) channels mediate a significant portion of the recep... Chylomicron- and VLDL-derived Lipids Enter the Heart through Different Pathways IN VIVO EVIDENCE FOR RECEPTOR- AND NON-RECEPTOR-MEDIATED FATTY ACID UPTAKE [作者：Bharadwaj, KG; Hiyama, Y; Hu, YY; Huggins, LA; Ramakrishnan, R; Abumrad, NA; Shulman, GI; Blaner, WS; Goldberg, IJ,期刊：Journal of Biological Chemistry, 页码：37976-37986 , 文章类型： Article，,卷期：2010年285-49] Lipids circulate in the blood in association with plasma lipoproteins and enter the tissues either after hydrolysis or as non-hydrolyzable lipid esters. We studied cardiac lipids, lipoprotein lipid uptake, and gene expre... Insight into the Role of Dynamics in the Conformational Switch of the Small GTP-binding Protein Arf1 [作者：Buosi, V; Placial, JP; Leroy, JL; Cherfils, J; Guittet, E; van Heijenoort, C,期刊：Journal of Biological Chemistry, 页码：37987-37994 , 文章类型： Article，,卷期：2010年285-49] Activation of the small GTP-binding protein Arf1, a major regulator of cellular traffic, follows an ordered sequence of structural events, which have been pictured by crystallographic snapshots. Combined with biochemical... The Eukaryotic Translation Elongation Factor 1B gamma Has a Non-guanine Nucleotide Exchange Factor Role in Protein Metabolism [作者：Esposito, AM; Kinzy, TG,期刊：Journal of Biological Chemistry, 页码：37995-38004 , 文章类型： Article，,卷期：2010年285-49] The turnover of damaged proteins is critical to cell survival during stressful conditions such as heat shock or oxidative stress. The accumulation of misfolded proteins in the endoplasmic reticulum (ER) is toxic to cells... The Extreme C Terminus of the ABC Protein DrrA Contains Unique Motifs Involved in Function and Assembly of the DrrAB Complex [作者：Zhang, H; Pradhan, P; Kaur, P,期刊：Journal of Biological Chemistry, 页码：38324-38336 , 文章类型： Article，,卷期：2010年285-49] Two novel regulatory motifs, LDEVFL and C-terminal regulatory Glu (E)-rich motif (CREEM), are identified in the extreme C terminus of the ABC protein DrrA, which is involved in direct interaction with the N-terminal cyto... Defective in Cuticular Ridges (DCR) of Arabidopsis thaliana, a Gene Associated with Surface Cutin Formation, Encodes a Soluble Diacylglycerol Acyltransferase [作者：Rani, SH; Krishna, THA; Saha, S; Negi, AS; Rajasekharan, R,期刊：Journal of Biological Chemistry, 页码：38337-38347 , 文章类型： Article，,卷期：2010年285-49] A key step in the triacylglycerol (TAG) biosynthetic pathway is the final acylation of diacylglycerol (DAG) by DAG acyltransferase. In silico analysis has revealed that the DCR (defective in cuticular ridges) (At5g23940)...